Bioassays


Book Description

Bioassays: Advanced Methods and Applications provides a thorough understanding of the applications of bioassays in monitoring toxicity in aquatic ecosystems. It reviews the newest tests and applications in discovering compounds and toxins in the environment, covering all suitable organisms, from bacteria, to microorganisms, to higher plants, including invertebrates and vertebrates. By learning about newer tests, water pollution control testing can be less time and labor consuming, and less expensive. This book will be helpful for anyone working in aquatic environments or those who need an introduction to ecotoxicology or bioassays, from investigators, to technicians and students. - Features chapters written by internationally renowned researchers in the field, all actively involved in the development and application of bioassays - Gives the reader an understanding of the advantages and deficiencies of available tests - Addresses the problem of understanding the impact of toxins in an aquatic environment and how to assess them







Bioassay Techniques for Drug Development


Book Description

The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa




Environmental Bioassay Techniques and their Application


Book Description

Proceedings of the First International Conference held in Lancaster, England, July 11-14, 1988







Methods in Chemical Ecology Volume 2


Book Description

Identification of chemicals that affect the naturally occurring interactions be tween organisms requires sophisticated chemical techniques, such as those docu mented in volume 1, in combination with effective bioassays. Without an effective bioassay, the identification becomes akin to looking for a needle in a haystack, but without any idea of what a needle looks like. To a large extent serniochemical identifications must be driven by bioassays. The design of bioassays for use in chemical ecology is governed by the sometimes conflicting objectives of ecological relevance and the need for simplic ity. Bioassay design should be based on observations of the interactions between organisms in their natural context, a theme that appears throughout this volume. As a result, this volume is as much about ecology and behavior as it is about specific methods. It is impossible to design a relevant bioassay, whether it is simple or complex, without understanding at least the fundamentals of how chemical cues or signals mediate the interaction in nature. Thus, the development of bioassay methods must be driven by an understanding of ecology and a knowledge of the natural history of the organisms under study. Given such an understanding, it is often possible to design assays that are both ecologically relevant and easy to perform.




Methods in Chemical Ecology Volume 1


Book Description

A working definition of the discipline of chemical ecology might be "the study of the structure, function, origin, and significance of naturally occurring compounds that mediate inter-and intraspecific interactions between organisms. " In particular, chemical ecology focuses on determining the role of semiochemicals and related compounds in their natural contexts. Thus, chemical ecology is distinct from disciplines such as pharmacology, in which compounds are screened for uses outside their natural context, for example in the screening of natural products for use as drugs. Superficially, many of the methods used in the various branches of natural products chemistry, such as pharmacology and chemical ecology, are very similar, but each branch has developed its own set of specialized methods for dealing with the problems characteristic of that discipline. For example, in chemical ecology, many semiochemicals are isolated and identified using only a few micrograms or less of material. Although the same general chromatographic and spectroscopic techniques are used as would be used with the identification of most organic compounds, specialized techniques have been developed for handling these very small quantities, allowing the maximum amount of informa tion to be recovered from the minimum amount of sample. These micro scale techniques, and the problems unique to working with very small amounts of sample, are rarely covered in detail in reference books on the isolation and identification of biologically active natural chemicals.




Beyond the Molecular Frontier


Book Description

Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.




Analytical Techniques in Environmental Chemistry 2


Book Description

Analytical Techniques in Environmental Chemistry 2 focuses on the establishment of analytical techniques in the management of compounds relative to their effects on health and nature. The book stresses that these analytical techniques are essential in order to cope with the problems arising from the utilization of these compounds. The selection contains the contributions of authors who have continuously performed studies on the analysis of organic and inorganic pollutants and monitoring strategies or case histories of compounds. These pieces focus on the role of analytical chemistry in the control of compounds, particularly if the compounds are seen to pose threat to health and the environment. The text presents studies on the determination of how these compounds can become pollutants, which are emphasized by the experiments and laboratory procedures mentioned in the book. Through research on hazardous compounds in different areas, the book manages to point out the differences of how these compounds can affect the environment and health. The text then proceeds by presenting various analytical techniques that could be employed to mitigate the hazardous nature of these compounds. The book is a reliable source of information for scholars and readers who are interested in studying how to control the hazardous effects of compounds both on health and the environment.




Chemical and Biological Terrorism


Book Description

The threat of domestic terrorism today looms larger than ever. Bombings at the World Trade Center and Oklahoma City's Federal Building, as well as nerve gas attacks in Japan, have made it tragically obvious that American civilians must be ready for terrorist attacks. What do we need to know to help emergency and medical personnel prepare for these attacks? Chemical and Biological Terrorism identifies the R&D efforts needed to implement recommendations in key areas: pre-incident intelligence, detection and identification of chemical and biological agents, protective clothing and equipment, early recognition that a population has been covertly exposed to a pathogen, mass casualty decontamination and triage, use of vaccines and pharmaceuticals, and the psychological effects of terror. Specific objectives for computer software development are also identified. The book addresses the differences between a biological and chemical attack, the distinct challenges to the military and civilian medical communities, and other broader issues. This book will be of critical interest to anyone involved in civilian preparedness for terrorist attack: planners, administrators, responders, medical professionals, public health and emergency personnel, and technology designers and engineers.