Author : Ramesh N. Patel
Publisher : CRC Press
Page : 878 pages
File Size : 47,78 MB
Release : 2006-09-26
Category : Medical
ISBN : 1420019376
Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemic
Author : Junhua (Alex) Tao
Publisher : John Wiley & Sons
Page : 250 pages
File Size : 31,75 MB
Release : 2009-07-23
Category : Science
ISBN : 0470823151
Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.
Author : Gonzalo de Gonzalo
Publisher : Royal Society of Chemistry
Page : 532 pages
File Size : 40,41 MB
Release : 2017-11-02
Category : Science
ISBN : 1782626190
Implementing biocatalytic strategies in an industrial setting at a commercial scale is a challenging task, necessitating a balance between industrial need against economic viability. With invited contributions from small and large-scale chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and key aspects to economically succeed. With its focus on industry related issues, this book will be a useful tool for future research by both practitioners and academics.
Author : Ching T. Hou
Publisher : CRC Press
Page : 563 pages
File Size : 50,19 MB
Release : 2006-12-26
Category : Science
ISBN : 9780849392825
Biocatalysis and biotechnology are rapidly advancing areas of research with the significant advantages of high specificity, efficiency, energy conservation, and pollution reduction. With applications in industrial processes and the huge world nutraceutical and functional food market, of which the US alone is responsible for more than $100 billion per year, this is clearly a domain that needs a comprehensive reference for the current knowledge in the field. Biocatalysis and Biotechnology for Functional Foods and Industrial Products is an in-depth collection of reviews of the current advances in biocatalysis and biotechnology as presented at the International Symposium on Biocatalysis and Biotechnology held at the National Chung Hsing University, Taichung, Taiwan in October 2005. With an emphasis on functional foods and industrial products, this is the most current compendium available. Internationally recognized scientists from US, Japan, Korea, Iceland, Germany, and Taiwan share their valuable research results on topics within the general definition of biocatalysis and biotechnology. Covering the latest applications for enzyme catalysis, biotransformation, bioconversion, fermentation, genetic engineering, and product recovery, this book outlines one-step catalytic reactions as well as many sequential reaction steps involved in production. Divided into two sections, the first presents cutting edge information on functional food research including health food, nutritional supplements, and nutraceuticals. Chapters include enzymatic fractionation, chemoenzymatic synthesis, and novel biofunctions for functional nutrients. The second section is devoted to industrial applications such as the biotransformation of aliphatic hydrocarbons, biodegradable industrial lubricants, and the stabilization of living microbial biological control agents for insecticides. Providing a comprehensive review of the modern development of biocatalysis and biotechnology, Biocatalysis and Biotechnology for Functional Foods and Industrial Products is a valuable reference for researchers and scientists as well as an indispensable introduction of the state-of-the-science for newcomers to the field.
Author : Peter Grunwald
Publisher : CRC Press
Page : 424 pages
File Size : 34,15 MB
Release : 2020-11-26
Category : Medical
ISBN : 1000067386
Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.
Author : Gonzalo de Gonzalo
Publisher : John Wiley & Sons
Page : 54 pages
File Size : 33,19 MB
Release : 2021-04-13
Category : Science
ISBN : 3527824456
This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.
Author : Lutz Hilterhaus
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 37,6 MB
Release : 2016-07-27
Category : Science
ISBN : 3527677143
This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.
Author : Heinrich Klefenz
Publisher : Wiley-VCH
Page : 328 pages
File Size : 44,67 MB
Release : 2002-04-22
Category : Medical
ISBN :
This volume focuses on pharmaceutical biotechnology as a key area of life sciences. The complete range of concepts, processes and technologies of biotechnology is applied in modern industrial pharmaceutical research, development and production. The results of genome sequencing and studies of biological-genetic function are combined with chemical, micro-electronic and microsystem technology to produce medical devices and diagnostic biochips. A multitude of biologically active molecules is expanded by additional novel structures created with newly arranged gene clusters and bio-catalytic chemical processes. New organisational structures in the co-operation of institutes, companies and networks enable faster knowledge and product development and immediate application of the results of research and process development. This book is the ideal source of information for scientists and engineers in research and development, for decision-makers in biotech, pharma and chemical corporations, as well as for research institutes, but also for founders of biotech companies and people working for venture capital corporations.
Author : Vivek Kothari
Publisher : Daya Books
Page : 296 pages
File Size : 16,99 MB
Release : 2007
Category : Medical
ISBN : 9788176221702
Bioacatalysis Has Increasingly Become The Technology Of Choice To Introduce Chirality In Fine-Chemical Processes. Biocatalysis Sculpts Chemical Precursors Into The Precise Molecular Shapes That Are The Heart Of Many Pharmaceuticals. In Reviewing How Biocatalysis Can Be Applied To Improve Chiral Synthesis For Pharmaceutical It Becomes Clear That There Will Be Many Opportunities Using A Simple Enzyme System But That Many Of The More Useful Applications Will Require The Whole Cell Because Of The Requirement For Cofactors. In The Ever More Global Commercial Arena, Biocatalysts Becomes Ever More Central To The Competitiveness Of Individual Products, Companies, Industries, And Countries. The Use Of Biocatalysis Often Leads To Less Complex, Syntheses, Lower Production Costs, And More Sustainable Production Processes. Written For Practitioners And Students Of Chemistry, Biology And Bioengineering, This Book Provides A Comprehensive Review Of The Applications Of Biocatalysis In The Pharmaceutical Industry. Contents Chaptre 1: Introduction; Chapter 2: Synthesis Of Chiral Intermediates; Chapter 3: Synthesis Of Amino Alcohols; Chapter 4: Enzymatic Synthesis Of Amplicillin; Chapter 5: Synthesis Of Chiral Amines With W-Transaminase; Chapter 6: Synthesis Of Chiral Long Chain Diamines And Tetramines; Chapter 7: Applications For Oxidoreductases; Chapter 8: Non-Aqueous Biocatalysis; Chapter 9: Eukaryotes For Industrial Biocatalysis; Chapter 10: Biopolymers For Biocatalysis; Chapter 11: Use Of Enantiopure Naphthalene Dihydrodiols; Chapter 12: Multidrug-Resistant Mycobacterium Tuberculosis; Chapter 13: Flavin Biochemistry.
Author : Andres R Alcantara
Publisher : MDPI
Page : 176 pages
File Size : 31,1 MB
Release : 2019-10-30
Category : Science
ISBN : 3039217089
Biocatalysis, that is, the use of biological catalysts (enzymes, cells, etc.) for the preparation of highly valuable compounds is undergoing a great development, being considered an extremely sustainable approach to undertaking environmental demands. In this scenario, this book illustrates the versatility of applied biocatalysis for the preparation of drugs and other bioactive compounds through the presentation of different research articles and reviews, in which several authors describe the most recent developments in this appealing scientific area. By reading the excellent contributions gathered in this book, it is possible to have an updated idea about new advances and possibilities for a new exciting future.
