Biocomputing 2017


Book Description

The Pacific Symposium on Biocomputing (PSB) 2017 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2017 will be held on January 4 – 8, 2017 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference. PSB 2017 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.




Biocomputing 2019 - Proceedings Of The Pacific Symposium


Book Description

The Pacific Symposium on Biocomputing (PSB) 2019 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2019 will be held on January 3 - 7, 2019 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2019 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.




Bioinformatics and Transcriptomics. Generation of a p53 Interactome


Book Description

Scientific Study from the year 2017 in the subject Medicine - Biomedical Engineering, University of Salford (School of Environmental and Life Sciences , ELLS), course: MSc Biomedical Science, language: English, abstract: Bioinformatics and computational biology provide us with the tools to collect, curate and analyse biological data and have seen increased usage in medicine and other scientific fields over the years. One of those areas of medicine where it is widely applied is in cancer research and chemotherapy. This report seeks to explore the properties and interactions of one gene, p53, which can be key to cancer research. This gene encodes the p53 protein which works by stopping cell cycle progression and hence preventing uncontrolled cell proliferation. It is also involved in activating the transcription of DNA repair proteins and inducing apoptosis. The interactions between p53 and a host of other genes involved in the regulation of transcription was studied with the aid of several databases; NCBI Gene ,MotifMap, ChampionChip ,TRED, STRING and a visualization software , Cytoscape, with which a Boolean model was produced from ten p53 interactions. p21 is a very important gene which is regulated by p53 in its transcriptional activation and tumour suppressing function .A study of some of the properties of p21 (with NCBI Gene) and a comparison of the of the number of transcription factors which regulate p21 was done using MofiMap, ChampionChip and TRED and found to be higher for ChampionChip which provided a more extensive search than MotifMap. Meanwhile TRED produced no results for gene search. In conclusion, the report demonstrated that the usually very complex network of p53 interactions can be simplified by a Boolean model to show the transcription factors regulated by p53 and the nature of interaction (activation or inhibition). Understanding these pathways of interactions might be very useful in cancer research and treatment.



















From Fundamental Genomics to Systems Biology


Book Description

Accompanying CD-ROM contains text.




Bioinformatics


Book Description

Aimed at students of biotechnology, Bioinformatics: Experiments, Databases, Tools, and Algorithms describes the methods used to store, retrieve, and derive data from databases using various tools.