Bioinformatics Tools for Pharmaceutical Drug Product Development


Book Description

BIOINFORMATICS TOOLS FOR Pharmaceutical DRUG PRODUCT DLEVELOPMENT A timely book that details bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies, for drug development in the pharmaceutical and medical sciences industries. The book contains 17 chapters categorized into 3 sections. The first section presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. The following 2 sections include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall. Readers will find in this book: Applications of bioinformatics tools for pharmaceutical drug product development like process development, pre-clinical development, clinical development, commercialization of the product, etc.; The ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach; The broad and deep background, as well as updates, on recent advances in both medicine and AI/ML that enable the application of these cutting-edge bioinformatics tools. Audience The book will be used by researchers and scientists in academia and industry including drug developers, computational biochemists, bioinformaticians, immunologists, pharmaceutical and medical sciences, as well as those in artificial intelligence and machine learning.




Pharmacogenomics in Drug Discovery and Development


Book Description

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.




Artificial Intelligence in Drug Discovery


Book Description

Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.







Bioinformatics and Drug Discovery


Book Description

Recent advances in drug discovery have been rapid. The second edition of Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter, detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.




Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences


Book Description

Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences brings together two very important fields in pharmaceutical sciences that have been mostly seen as diverging from each other: chemoinformatics and bioinformatics. As developing drugs is an expensive and lengthy process, technology can improve the cost, efficiency and speed at which new drugs can be discovered and tested. This book presents some of the growing advancements of technology in the field of drug development and how the computational approaches explained here can reduce the financial and experimental burden of the drug discovery process. This book will be useful to pharmaceutical science researchers and students who need basic knowledge of computational techniques relevant to their projects. Bioscientists, bioinformaticians, computational scientists, and other stakeholders from industry and academia will also find this book helpful. - Provides practical information on how to choose and use appropriate computational tools - Presents the wide, intersecting fields of chemo-bio-informatics in an easily-accessible format - Explores the fundamentals of the emerging field of chemoinformatics and bioinformatics




Pharmaceutical Biotechnology


Book Description

Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, initial chapters offer a broad introduction to protein science and recombinant DNA technology- key areas that underpin the whole subject. Subsequent chapters focus upon the development, production and analysis of these substances. Finally the book moves on to explore the science, biotechnology and medical applications of specific biotech products categories. These include not only protein-based substances but also nucleic acid and cell-based products. introduces essential principles underlining modern biotechnology- recombinant DNA technology and protein science an invaluable introduction to this fast-moving subject aimed specifically at pharmacy and medical students includes specific ‘product category chapters’ focusing on the pharmaceutical, medical and therapeutic properties of numerous biopharmaceutical products. entire chapter devoted to the principles of genetic engineering and how these drugs are developed. includes numerous relevant case studies to enhance student understanding no prior knowledge of protein structure is assumed




Artificial Intelligence in Microbiology: Scope and Challenges Volume 1


Book Description

Nowadays, the field of microbiology is undergoing a revolutionary change due to the emergence of Artificial Intelligence (AI). AI is being used to analyze massive data in a predictable form, about the behavior of microorganisms, to solve microbial classification-related problems, exploring the interaction between microorganisms and the surrounding environment. It also helps to extract novel microbial metabolites which have been used in various fields like medical, food and agricultural industries. As the pace of innovation in Microbiology is accelerating, the use of AI in these industries will be beneficial. AI will not only show its extraordinary potential in expanding the market of antibiotics, food, and agriculture but also offer an eco-friendly, safer, and profitable solution to the respective industries. It would be challenging to search out specific features and discuss future research on AI in microbiology with a wide perspective. - Uncovering extended functions of AI in Microbiology. - Production and development of novel drug targets through AI. - Challenges for using and selecting appropriate AI tools in health, agriculture and food sector




Using Traditional Design Methods to Enhance AI-Driven Decision Making


Book Description

In the rapidly evolving landscape of industrial activities, artificial intelligence (AI) has emerged as a powerful force driving transformative change. Among its many applications, AI has proven to be instrumental in reducing processing costs associated with optimization challenges. The intersection of AI with optimization and multi-criteria decision making (MCDM) techniques has led to practical solutions in diverse fields such as manufacturing, transportation, finance, economics, and artificial intelligence. Using Traditional Design Methods to Enhance AI-Driven Decision Making delves into a wide array of topics related to optimization, decision-making, and their applications. Drawing on foundational contributions, system developments, and innovative techniques, the book explores the synergy between traditional design methods and AI-driven decision-making approaches. The book is ideal for higher education faculty and administrators, students of higher education, librarians, researchers, graduate students, and academicians. Contributors are invited to explore a wide range of topics, including the role of AI-driven decision-making in leadership, trends in AI-driven decision-making in Industry 5.0, applications in various industries such as manufacturing, transportation, healthcare, and banking services, as well as AI-driven optimization in mechanical engineering and materials.




ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS


Book Description

Welcome to the world of Advanced Biopharmaceutics & Pharmacokinetics, a field that lies at the intersection of pharmaceutical science, medicine, and technology. This book represents an exploration into the intricate mechanisms governing the fate of drugs in the human body, the evolving landscape of drug delivery systems, and the cutting-edge methodologies shaping the future of pharmacokinetics. In the ever-evolving landscape of pharmaceuticals, the quest for optimizing drug delivery, enhancing therapeutic efficacy, and minimizing adverse effects has become increasingly complex. This book seeks to unravel these complexities by delving into the advanced principles of biopharmaceutics and pharmacokinetics, providing a comprehensive guide for researchers, practitioners, and students in the pharmaceutical sciences. The journey into Advanced Biopharmaceutics & Pharmacokinetics begins with a thorough examination of the fundamental concepts that underpin drug absorption, distribution, metabolism, and excretion. From there, we navigate through the intricacies of drug formulation and delivery systems, exploring the latest innovations in nanomedicine, biosimilars, and targeted drug delivery. Throughout the chapters, we highlight the pivotal role of pharmacokinetics in drug development, emphasizing its importance in optimizing dosage regimens, understanding drug interactions, and individualizing therapies in the era of precision medicine. The integration of advanced technologies, such as systems pharmacology and therapeutic drug monitoring, further enriches the discussion, offering a glimpse into the future of pharmacokinetic research.