Biologic Regulation of Physical Activity


Book Description

Biologic Regulation of Physical Activity provides readers with a cutting-edge perspective of underlying issues that may contribute to the obesity epidemic. It offers evidence of a biologic regulator affecting physical activity and explores implications of such biologic control on activity.




Biologic Regulation of Physical Activity


Book Description

Biologic Regulation of Physical Activity provides readers with a cutting-edge perspective of underlying issues that may contribute to the obesity epidemic. It offers evidence of a biologic regulator affecting physical activity and explores implications of such biologic control on activity.







Educating the Student Body


Book Description

Physical inactivity is a key determinant of health across the lifespan. A lack of activity increases the risk of heart disease, colon and breast cancer, diabetes mellitus, hypertension, osteoporosis, anxiety and depression and others diseases. Emerging literature has suggested that in terms of mortality, the global population health burden of physical inactivity approaches that of cigarette smoking. The prevalence and substantial disease risk associated with physical inactivity has been described as a pandemic. The prevalence, health impact, and evidence of changeability all have resulted in calls for action to increase physical activity across the lifespan. In response to the need to find ways to make physical activity a health priority for youth, the Institute of Medicine's Committee on Physical Activity and Physical Education in the School Environment was formed. Its purpose was to review the current status of physical activity and physical education in the school environment, including before, during, and after school, and examine the influences of physical activity and physical education on the short and long term physical, cognitive and brain, and psychosocial health and development of children and adolescents. Educating the Student Body makes recommendations about approaches for strengthening and improving programs and policies for physical activity and physical education in the school environment. This report lays out a set of guiding principles to guide its work on these tasks. These included: recognizing the benefits of instilling life-long physical activity habits in children; the value of using systems thinking in improving physical activity and physical education in the school environment; the recognition of current disparities in opportunities and the need to achieve equity in physical activity and physical education; the importance of considering all types of school environments; the need to take into consideration the diversity of students as recommendations are developed. This report will be of interest to local and national policymakers, school officials, teachers, and the education community, researchers, professional organizations, and parents interested in physical activity, physical education, and health for school-aged children and adolescents.




Physical Activity in Aging


Book Description

"A 2016 study concluded that the elderly spend 2.5 times the national average on health services (De Nardi 2016). Despite consisting of only 14 percent of the United States population, the elderly accounted for 34 percent of all medical spending, and accounted for 73 percent of all deaths (De Nardi 2016). In addition, current projections estimate that with the aging of the baby boomer generation, the percentage of the population that is older than 65 will swell to approximately 20 percent of the population by 2030 (Ortman 2014). If the medical spending holds, this will coincide with massive increases in health service utilization and costs. Costs of health services are currently a contentious topic at both the state and federal levels, with a seemingly insurmountable divide existing between the two main US political parties. This research attempted to gain better understanding of the health effects that physically active lifestyles elicit in older populations. Previous research connected biological outcomes across several systems to improvements in systemic health, but our efforts attempted to apply similar analysis to generalized activity levels in the form of various reported activities standardized using metabolic equivalent task metrics. For this study, the examined age group expanded beyond individuals that are older than 65, and instead included all ages over 50. Analysis used Metabolic Equivalent Task Minutes (METS) as a representative variable of general activity, using ordinary least squares regression to analyze effects on biological systems. It was found that with the selected model, there was minimal to no impact biologically that correlated with increasing general activity levels among the 50+ community. Secondary analyses were performed that lacked sufficient statistical power, however their results may be useful in determining further course of study. In the first of the secondary analyses, we used the exercise model to assess changes in individual perception of health. In this there were very few correlations found between biological health and perceptions of health. Finally, biological health and perception of health were regressed against several variables that were indicative of medical service utilization Analysis found that for the selected cohort, there were minimal measurable biological effects relating to exercise, but that the more active respondents correlated with higher belief in control over their health, as well as reductions in health-based restrictions on ability to perform intermediate level activities of daily living."--Abstract.




Mitochondria in Obesity and Type 2 Diabetes


Book Description

Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes




Controversies in Exercise Science


Book Description

Controversies in Exercise Science introduces a series of selected unresolved issues in the field of human exercise science. The common thread to all of these topics is that, in their ultimate resolution, they offer promise of insights into the essential principles of physiological systems and how these respond to the stresses of exercise. Each case study includes an examination of research surrounding each issue; the innovative aspect, however, will be that each of these controversies will be presented in the context of an historical and/or philosophical perspective. These chapter include topics related to basic exercise physiology, sports, physical activity, and exercise health. Underlying each of these debates lie clues which may offer insights into the basic nature of living beings. Aimed at both academics and practitioners in the fields of exercise science, biology, and related sports science disciplines, Controversies in Exercise Science provides arguments for both sides of several selected contemporary controversies in the field of exercise science and, while no ultimate resolution will be provided, the goal is, rather, to offer the reader sufficient "raw material" on which he or she might make their own judgement on the matters presented.




The Biology of Exercise


Book Description

Exercise training provokes widespread transformations in the human body, requiring coordinated changes in muscle composition, blood flow, neuronal and hormonal signaling, and metabolism. These changes enhance physical performance, improve mental health, and delay the onset of aging and disease. Understanding the molecular basis of these changes is therefore important for optimizing athletic ability and for developing drugs that elicit therapeutic effects. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biological basis of exercise from the molecular to the systemic levels. Contributors discuss how transcriptional regulation, cytokine and hormonal signaling, glucose metabolism, epigenetic modifications, microRNA profiles, and mitochondrial and ribosomal functions are altered in response to exercise training, leading to improved skeletal muscle, hippocampal, and cardiovascular function. Cross talk among the pathways underlying tissue-specific and systemic responses to exercise is also considered. The authors also discuss how the understanding of such molecular mechanisms may lead to the development of drugs that mitigate aging and disease. This volume will therefore serve as a vital reference for all involved in the fields of sports science and medicine, as well as anyone seeking to understand the molecular mechanisms by which exercise promotes whole-body health.




Controversies in Exercise Science


Book Description

Controversies in Exercise Science introduces a series of selected unresolved issues in the field of human exercise science. The common thread to all of these topics is that, in their ultimate resolution, they offer promise of insights into the essential principles of physiological systems and how these respond to the stresses of exercise. Each case study includes an examination of research surrounding each issue; the innovative aspect, however, will be that each of these controversies will be presented in the context of an historical and/or philosophical perspective. These chapter include topics related to basic exercise physiology, sports, physical activity, and exercise health. Underlying each of these debates lie clues which may offer insights into the basic nature of living beings. Aimed at both academics and practitioners in the fields of exercise science, biology, and related sports science disciplines, Controversies in Exercise Science provides arguments for both sides of several selected contemporary controversies in the field of exercise science and, while no ultimate resolution will be provided, the goal is, rather, to offer the reader sufficient "raw material" on which he or she might make their own judgement on the matters presented.