Biological Tolerance to Air Blast and Related Biomedical Criteria


Book Description

Experience with animals exposed in a variety of above and below ground structures during full-scale field operations at the Nevada Test Site in 1953, 1955 and 1957 were reviewed. The data were assembled and summarized to illustrate the nature of the blast-induced problems of significance in protective shelters, "open" as well as "closed". Potential hazards were related to the following: various patterns of variation in environmental pressure; translational events associated with transient, high-velocity winds, ground shock and gravity involving the impact of energized inanimate objects on the one hand the the consequences of whole-body displacement on the other; non-line-of-site thermal phenomena including hot objects and rapidly moving hot, dust- laden air and debris; and dust, in the respirable size range, sufficiently high in concentration even in "closed" shelters as to warrant design measures to minimize or eliminate the occurrence of small particulates whether arising from wall spalling or otherwise. Tentative biological criteria, conceived to help assess human hazards from blast-related phenomena, were presented. Relevant data from the literature and on- going research in environmental medicine were set forth to aid the reader in appreciating how the criteria were formulated, what information was extrapolated from animal data, and wherein "best estimates" were employed. "State-of-the-art" concepts were noted to emphasize areas in which more thinking and research must continue if more refined, complete and adequate criteria are to be forthcoming for assessing man's response to blast-induced variation in his immediate environment.







Tertiary Blast Effects


Book Description

A total of 455 mice, rats, guinea pigs and rabbits were subjected to impact at velocities ranging between 25 ft/sec and 51 ft/sec. The desired velocities were generated by allowing the animals to free-fall from various heights to a flat concrete pad. The ventral surface of each animal was the area of impact. Probit analyses of the 24-hr mortality data yielded LD50 impact velocities with 95 per cent confidence limits as follows: mouse, 39.4 (37.4-42. 0) ft/sec; rat, 43.5 (42.0 - 44.8) ft/sec; guinea pig, 31.0 (30.0 - 31.9) ft/ sec. The LD50 figures for the mouse and rat were significantly higher, statistically, than those for the guinea pig and rabbit. The small spread in the LD50 values suggested little variation in the tolerance of biological systems to impact. Further, the steepness of the mortality curves indicated a narrow survival range to impact. Extrapolation of the experimental data to the 70 kg animal yielded a predicted LD50 impact velocity of 26 ft/sec (18 mph). Literature relevant to the human case was reviewed and the tentative applicability of the predicted figures to adult man was discussed. (Author).




Blast Biology


Book Description




Biological Sequence Analysis


Book Description

Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.




Technical Photography (high Speed-blast Biology)


Book Description

The purpose of this project was to provide the photographic requirements for Civil Effects Test Group projects concerned with the biological phenomena of blast. Preshot and postshot photographs were obtained of animals and/or structures. High-speed motion picture sequences of group-shelter interiors containing animals were attempted. Medical photographs of gross specimens were obtained at the time of autopsy of experimental animals. Documentary and technical photographs were obtained for a project studying missile behavior. Styrofoam cells showing evidence of missile penetration were photographed in a specially constructed grid providing a system of coordinates for accurate reference. A recommendation for such a project to maintain on-site processing facilities was made. Several conclusions were drawn regarding changes necessary to better assure motion picture results under extreme circumstances.




Blast Injury Science and Engineering


Book Description

This heavily revised second edition provides a comprehensive multi-disciplinary resource on blast injuries. It features detailed information on the basic science, engineering, and medicine associated with blast injuries. Clear, easy to understand descriptions of the basic science are accompanied by case studies of a variety of clinical problems including heterotopic ossification, hearing damage, and traumatic brain injury, enabling the reader to develop a deep understanding of how to appropriately apply the relevant science into their clinical practice. The use of prosthetics, orthotics and osseointegration in rehabilitation is also covered. Blast Injury Science and Engineering: A Guide for Clinicians and Researchers is a valuable interdisciplinary text primarily focused towards clinical medical professionals and trainees seeking to develop a thorough understanding of injury mechanisms, and the latest treatment techniques. In addition, this resource is of use to individuals in other fields whose work centres around blast injury science such as injury mitigation researchers, military scientists and engineers.




Biodefense in the Age of Synthetic Biology


Book Description

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.