Bronchiolitis Obliterans Syndrome in Lung Transplantation


Book Description

Bronchiolitis Obliterans Syndrome in Lung Transplantation presents the most current and up-to-date evidence regarding the diagnosis and management of BOS. In-depth chapters provide readers with a comprehensive understanding of the definition and changing perceptions of the nature of BOS as a clinical and pathologic entity, immune and non-immune mechanisms that have been identified as risk factors for the development of BOS, and interventions that may prove to be clinically useful for the prevention or treatment of BOS. In addition to outlining the current state of knowledge, each chapter provides the reader with the most current and ongoing research in the field as well as identifies areas where future research is needed. Written by an international group of expert authors, Bronchiolitis Obliterans Syndrome in Lung Transplantation is an important new text, that is essential reading for pulmonologists, primary care practitioners, respiratory care practitioners and clinical researchers.







Pulmonary Considerations in Solid Organ and Hematopoietic Stem Cell Transplantation, An Issue of Clinics in Chest Medicine, E-Book


Book Description

This issue of Clinics in Chest Medicine focuses on Pulmonary Considerations in Solid Organ and Hematopoietic Stem Cell Transplantation. Editors Vivek Ahya and Joshua Diamond have assembled an expert team of authors on topics such as: Overview of HSCT Transplantation and future directions in treatment of hematologic malignancies; Early Pulmonary complications of HSCT and Prognosis of Respiratory FailureLate Pulmonary complications of HSCT; Overview of Lung Transplantation, Heart-lung transplantation, Lung-Liver transplantation and combined HSCT and lung transplantation; Primary graft dysfunction after Lung Transplantation; Extracorporeal life support (ECLS) in lung transplantation; Evaluation and Management of the potential lung donor (including EVLP); Acute rejection & antibody mediated rejection in lung transplantation; Chronic lung allograft dysfunction (CLAD); Airway complications in lung transplantation; PTLD in solid organ and HSCT transplantation; Respiratory Bacterial and Mycobacterial Infections in solid organ transplantation and HSCT; Respiratory Viral infections in solid organ transplantation and HSCT; Respiratory Fungal infections in solid organ and hematopoietic stem cell transplantation; Non-infectious pulmonary complications of Liver, Heart and Kidney Transplantation; Hepatopulmonary syndrome and portal- pulmonary hypertension in liver failure; implications for liver transplantation.




Chronic Graft Versus Host Disease


Book Description

Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.




Lung Transplantation


Book Description

Lung transplantation is a treatment option for selected patients who are not responding to maximal medical therapy, or for whom no effective medical therapy exists. This Monograph provides a comprehensive guide to the recent advances in lung transplantation, and includes coverage of donor selection, immunosuppression, infectious and noninfectious complications, and management of bronchiolitis obliterans syndrome and post-transplant lymphoproliferative disease emerging after lung transplantation.




Exhaled Biomarkers


Book Description

Exhaled air contains numerous substances, often in extremely low concentrations. The development of sensitive detection techniques has made it possible to examine the composition of exhaled air in relation to a variety of airway diseases and other disorders. In this book, an overview of current cutting-edge breath analysis techniques and their clinical applications is provided for the clinician. The various contributions give a fascinating perspective of a future where new, highly sensitive methodologies will enable clinicians to diagnose and monitor a wide variety of diseases merely by taking.




Therapeutic Drug Monitoring


Book Description

Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques