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Biomarkers of Kidney Disease

Author : Charles L. Edelstein

Publisher : Academic Press

Page : 455 pages

File Size : 10,31 MB

Release : 2010-10-27

Category : Science

ISBN : 0123756731

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Book Description

A biomarker is a molecule that is measured as a marker of normal biological processes, disease processes or the response to a diagnostic or therapeutic intervention. Kidney diseases like acute kidney injury, chronic kidney disease, diabetic nephropathy, glomerular disease, renal cancer and preeclampsia still have a high morbidity. Measurement of biomarkers in the blood or urine that detect patients at risk of kidney diseases or that detect kidney diseases in the earliest stage may ultimately result in preventative or earlier or more effective treatments for kidney diseases. Biomarkers of Kidney Disease reviews the basic and clinical research on biomarkers of the common kidney diseases including acute kidney injury, chronic kidney disease, renal cancer, diabetic nephropathy, glomerular disease and preeclampsia. The characteristics of an ideal biomarker of kidney diseases and statistical analysis of biomarker studies is detailed. The latest techniques for biomarker detection like metabolomics and proteomics is covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation and preeclampsia. - Presents a comprehensive, translational source for all aspects of renal biomarkers in one reference work - Experts in renal disease biomarkers (from all areas of academic and medical research) take readers from the bench research (cellular and molecular mechanism) to new therapeutic approaches



Kidney Biomarkers

Author : Seema S. Ahuja

Publisher : Academic Press

Page : 342 pages

File Size : 45,90 MB

Release : 2020-07-17

Category : Science

ISBN : 0128159235

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Book Description

Since laboratory testing and biomarkers are an integral part in the diagnosis and treatment of kidney disease, Kidney Biomarkers: Clinical Aspects and Laboratory Determination covers currently used biomarkers as well as markers that are in development. Laboratories are increasingly more involved in the follow-up confirmatory laboratory testing and this unique volume showcases the collaboration needed to solve diagnostic clinical puzzles between the laboratory and clinician. This volume provides guidance on laboratory test selection and results interpretation in patients. Sources of inaccurate results in the measurement of kidney biomarkers are discussed along with possibility of eliminating such interferences. Each chapter is organized with a uniform easy-to-follow format with insightful case examples highlighting the collaboration between clinical laboratorians and clinicians.



Biomarkers in Kidney Disease

Author : Vinood B. Patel

Publisher : Springer

Page : 0 pages

File Size : 38,15 MB

Release : 2016-03-11

Category : Medical

ISBN : 9789400776982

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Book Description

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.



ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes

Author : J.A. Kellum

Publisher : Karger Medical and Scientific Publishers

Page : 218 pages

File Size : 25,60 MB

Release : 2013-05-14

Category : Medical

ISBN : 3318024074

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Book Description

Associated with both acute kidney injury (AKI) and cardio-renal syndromes (CRS), new biomarkers represent both a popular area of investigation and a new opportunity for advancement of therapy. This book contains the resolutions of the most recent ADQI conferences on biomarkers in AKI (Dublin) and on cardio-renal syndromes (Venice). The first part answers specific questions about new biomarkers and their use and utility in AKI: What are the most suitable candidate molecules and physiologic measures, how solid and evidence based is the discovery phase? How can we incorporate the new biomarkers in the AKI conceptual model describing the evolution from susceptibility to insult, decreased GFR and organ death? Even if we have a positive biomarker pattern and we can identify patients at risk or patients with early or even subclinical AKI, how is this information affecting our clinical behavior and practice? The second part is dedicated to the appraisal of the current knowledge about the pathophysiological mechanisms involved in different forms of CRS: it contains contributions on the state-of-the-art knowledge and practice of CRS, particularly focusing on the pathophysiology of the five subtypes. Acute and chronic mechanisms of damage are explored in depth, with particular attention to the primacy of organ involvement and the subsequent pathways of organ crosstalk.Presenting the most recent research in the field of biomarkers, AKI and CRS, this publication is an important educational tool for advanced investigators and clinical experts, but also for students and fellows.



Nephrology and Public Health Worldwide

Author : G.B. Silva Junior

Publisher : Karger Medical and Scientific Publishers

Page : 369 pages

File Size : 50,98 MB

Release : 2021-11-02

Category : Medical

ISBN : 331806937X

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Book Description

Nephrology is one of the fastest growing specialties in medicine. Nevertheless, kidney disease is one of the most serious unmet health needs in many countries. To provide healthcare access with the desirable equity worldwide, the nephrology community needs to discuss this public health issue and take part in decisions for elaboration of public health policies with more justice and equity. This book brings together key current public health problems that affect kidney function and illuminates them in contributions by an international group of nephrologists and general practitioners. The chapters review current knowledge and provide guidelines to manage these conditions and decrease the disease burden. At the end, developments in the digital era and their application to kidney disease treatment are synthesized, and a broader outlook on the future of nephrology is given. Ultimately, the publication aims to gather nephrology and public health expertise from researchers from all over the world, providing a broad vision of issues that must be discussed and overcome to guarantee a better treatment for patients with kidney diseases in the world today.



Controversies in Acute Kidney Injury

Author : J.A. Kellum

Publisher : Karger Medical and Scientific Publishers

Page : 267 pages

File Size : 16,67 MB

Release : 2011-09-15

Category : Science

ISBN : 3805598114

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Book Description

Acute kidney injury (AKI) is a serious and as yet incompletely understood disorder in which sudden impairment of kidney function occurs secondary to one or more of a variety of underlying conditions. This disorder is very common in (elderly) ICU patients and is associated with very high mortality. Many of those who survive suffer from permanent kidney failure and other long-term morbidities, which may include cardiovascular disease and immune dysfunction. Epidemiologic evidence suggests that AKI is not a single disease, but a syndrome comprised of multiple, often coexisting, etiologies. Being usually part of multiorgan failure syndrome, it calls for multiple organ support therapy.The publication at hand contains sections on prerenal azotemia syndromes, dying ‘of’ or ‘with’ AKI, pathophysiology of sepsis-induced acute kidney injury, developments in prevention / treatment / rehabilitation, and renal support. Reporting the latest recommendations from experts, it provides valuable information for those that are interested in understanding the disorder and its treatment options.





Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook

Author : Sidharth Kumar Sethi

Publisher : Springer

Page : 370 pages

File Size : 12,35 MB

Release : 2019-02-01

Category : Medical

ISBN : 9811322767

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Book Description

This book covers all key aspects of critical care in pediatric nephrology, including acute dialysis in sick children. It also provides detailed protocols for managing fluid and electrolyte balance and dialysis in children in intensive care. In addition, this quick guide discusses innovations in pediatric renal replacement therapy technologies, such as plasma exchange, CARPEDIEM, NIDUS and aquadex. This is a go-to book for intensivists, physicians and trainees working in pediatric intensive care units.



Acute Kidney Injury - Basic Research and Clinical Practice

Author : X. Ding

Publisher : Karger Medical and Scientific Publishers

Page : 175 pages

File Size : 47,68 MB

Release : 2018-01-23

Category : Medical

ISBN : 3318063118

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Book Description

Acute Kidney Injury (AKI) is a complex syndrome that is prevalent among hospitalized patients. In recent years, occurrence of AKI events has risen due to a growing susceptibility of fragile and elderly subjects and an increase in the use of complex procedures such as cardiovascular surgery and imaging techniques. Exposure to potentially nephrotoxic drugs, such as new chemotherapeutic agents, is also proving to be a cause of AKI. This book summarizes recent advances in various settings. A reappraisal of current definitions and staging classifications for AKI in the literature is followed by a description of new criteria for identifying patients at risk and characterizing early kidney damage by using biomarkers. Other important topics include the sequelae of AKI and AKI in special populations such as children, the elderly, and those with cancer. The effects of AKI and its consequences on healthcare expenditures are also addressed from several perspectives. AKI management requires the cooperation of different specialists to optimize outcomes. This book is thus a perfect tool not only for nephrologists, but for every specialist involved in the complicated endeavor of improving patient care.



Diagnostics, Risk Factors, Treatment and Outcomes of Acute Kidney Injury in a New Paradigm

Author : Wisit Cheungpasitporn

Publisher : MDPI

Page : 574 pages

File Size : 46,97 MB

Release : 2020-12-10

Category : Medical

ISBN : 3039360868

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Book Description

Acute kidney injury (AKI) is a frequent clinical syndrome among hospitalized patients, independently associated with both short- and long-term mortality. Previous investigations attempted to identify effective interventions to prevent AKI or promote kidney function recovery in patients with AKI. Most were unsuccessful. Hence, additional studies are required in the field of AKI research. In this Special Issue, we are making a call to action to stimulate researchers and clinicians to submit their studies on AKI conducted in nephrology, internal medicine, critical care, and other disciplines that will provide additional knowledge and skills in the field of AKI research, ultimately to improve patient outcomes.