Biomedical Magnetic Resonance Technology


Book Description

Nuclear magnetic resonance is now widely used in hospitals and research laboratories worldwide for medical purposes. Biomedical Magnetic Resonance Imaging is the first book to concentrate on how the instrumentation involved works rather than on the applications of the technique. In order to help the reader fully understand how an NMR imaging or spectroscopy system works the book takes an in-depth look at the principles behind the different components of the machine. Starting with a short history of the developments of nuclear magnetic resonance, the authors go on to describe all the different areas of instrumentation, such as the receiver and the magnet. A full explanation of the electronics and computer hardware and software appears for the first time in book form, completing this thorough view of an NMR system. Each chapter builds from a basic to a more sophisticated level of understanding and numerous illustrations help the reader to grasp the concepts. For the most part, mathematical descriptions appear at the ends of chapters, to place the emphasis of the book on the understanding of underlying principles. Biomedical Magnetic Resonance Imaging will be invaluable to all medical physicists, technicians, researchers and engineers working with NMR, containing as it does both theoretical and practical data to enable users to get the most out of their machines.




Quantitative Magnetic Resonance Imaging


Book Description

Quantitative Magnetic Resonance Imaging is a 'go-to' reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: - The basic physics behind tissue property mapping - How to implement basic pulse sequences for the quantitative measurement of tissue properties - The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* - The pros and cons for different approaches to mapping perfusion - The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor - maps and more complex representations of diffusion - How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed - How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance - Fingerprinting can be used to accelerate or improve tissue property mapping schemes - How tissue property mapping is used clinically in different organs - Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds - Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements - Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges - Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches




Electromagnetic Analysis and Design in Magnetic Resonance Imaging


Book Description

This book presents a comprehensive treatment of electromagnetic analysis and design of three critical devices for an MRI system - the magnet, gradient coils, and radiofrequency (RF) coils. Electromagnetic Analysis and Design in Magnetic Resonance Imaging is unique in its detailed examination of the analysis and design of the hardware for an MRI system. It takes an engineering perspective to serve the many scientists and engineers in this rapidly expanding field. Chapters present: an introduction to MRI basic concepts of electromagnetics, including Helmholtz and Maxwell coils, inductance calculation, and magnetic fields produced by special cylindrical and spherical surface currents principles for the analysis and design of gradient coils, including discrete wires and the target field method analysis of RF coils based on the equivalent lumped-circuit model as well as an analysis based on the integral equation formulation survey of special purpose RF coils analytical and numerical methods for the analysis of electromagnetic fields in biological objects With the continued, active development of MRI instrumentation, Electromagnetic Analysis and Design in Magnetic Resonance Imaging presents an excellent, logically organized text - an indispensable resource for engineers, physicists, and graduate students working in the field of MRI.







Fundamentals of MRI


Book Description

Fundamentals of MRI: An Interactive Learning Approach explores the physical principles that underpin the technique of magnetic resonance imaging (MRI).After covering background mathematics, physics, and digital imaging, the book presents fundamental physical principles, including magnetization and rotating reference frame. It describes how relaxati







Magnetic Resonance Technology


Book Description

Magnetic resonance systems are used in almost every academic and industrial chemistry, physics and biochemistry department, as well as being one of the most important imaging modalities in clinical radiology. The design of such systems has become increasingly sophisticated over the years. Static magnetic fields increase continuously, large-scale arrays of receive elements are now ubiquitous in clinical MRI, cryogenic technology has become commonplace in high resolution NMR and is expanding rapidly in preclinical MRI, specialized high strength magnetic field gradients have been designed for studying the human connectome, and the commercial advent of ultra-high field human imaging has required new types of RF coils and static shim coils together with extensive electromagnetic simulations to ensure patient safety. This book covers the hardware and engineering that constitutes a magnetic resonance system, whether that be a high-resolution liquid or solid state system for NMR spectroscopy, a preclinical system for imaging animals or a clinical system used for human imaging. Written by a team of experts in the field, this book provides a comprehensive and instructional look at all aspects of current magnetic resonance technology, as well as outlooks for future developments.




X-Nuclei Magnetic Resonance Imaging


Book Description

Standard magnetic resonance imaging (MRI) is a prominent clinical imaging modality used to diagnose and study diseases in vivo. It is principally based on the detection of the nuclei of hydrogen atoms (the proton; symbol 1H) in water molecules in tissues. X-nuclei MRI (also called non-proton MRI) is based on the detection of the nuclei of other atoms (X-nuclei) in the body, such as sodium (23Na), phosphorus (31P), chlorine (35Cl), potassium (39K), deuterium (2H), oxygen (17O), lithium (7Li), and fluorine (19F) using modified software and hardware. X-nuclei MRI can provide fundamental, new metabolic information related to cellular energetic metabolism and ion homeostasis in tissues that cannot be assessed using standard hydrogen MRI. This book is an introduction to the techniques and biomedical applications of X-nuclei MRI. It describes the theoretical and experimental basis of X-nuclei MRI, the limitations of this technique, and its potential biomedical applications for the diagnosis and prognosis of many disorders or for quantitative monitoring of therapies in a wide range of diseases. The book is divided into four parts. Part I includes a general description of X-nuclei nuclear magnetic resonance physics and imaging. Part II deals with the MRI of endogenous nuclei such as 23Na, 31P, 35Cl, and 39K; Part III, the MRI of endogenous/exogenous nuclei such as 2H and 17O; and Part IV, the MRI of exogenous nuclei such as 7Li and 19F. The book is illustrated throughout with many representative figures and includes references and reading suggestions in each section. It is the first book to introduce X-nuclei MRI to researchers, clinicians, students, and general readers who are interested in the development of imaging methods for assessing new metabolic information in tissues in vivo in order to diagnose diseases, improve prognosis, or measure the efficiency of therapies in a timely and quantitative manner. It is an ideal starting point for a clinical or scientific research project in non-proton MRI techniques.




Computational Molecular Magnetic Resonance Imaging for Neuro-oncology


Book Description

Based on the analytical methods and the computer programs presented in this book, all that may be needed to perform MRI tissue diagnosis is the availability of relaxometric data and simple computer program proficiency. These programs are easy to use, highly interactive and the data processing is fast and unambiguous. Laboratories (with or without sophisticated facilities) can perform computational magnetic resonance diagnosis with only T1 and T2 relaxation data. The results have motivated the use of data to produce data-driven predictions required for machine learning, artificial intelligence (AI) and deep learning for multidisciplinary and interdisciplinary research. Consequently, this book is intended to be very useful for students, scientists, engineers, the medical personnel and researchers who are interested in developing new concepts for deeper appreciation of computational magnetic resonance imaging for medical diagnosis, prognosis, therapy and management of tissue diseases.




Quantum Magnetic Resonance Imaging Diagnostics of Human Brain Disorders


Book Description

Magnetic resonance imaging (MRI) is a medical imaging technique used to visualize detailed internal structure of the body. This book discusses the recent developments in the field of MRI and its application to the diagnosis of human brain disorders. In addition, it reviews the newly emerging concepts and technology, based on the multi-coherence imaging (MQCI). It explains how computer packages can be used to generate images in diseased states and compare them to in vivo results. This will help improve the diagnosis of brain disorders based on the real-time events happening on atomic and molecular quantum levels. This is important since quantum-based MRI would enable clinicians to detect brain tumors at the very early stages. - Uses practical examples to explain the techniques - making it easier to understand the concepts - Uses diagrams to explain the physics behind the technique - avoiding the use of complicated mathematical formulae