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Biophysics and Biochemistry of Cartilage by NMR and MRI

Author : Yang Xia

Publisher : Royal Society of Chemistry

Page : 760 pages

File Size : 40,65 MB

Release : 2016-11-09

Category : Science

ISBN : 1782623663

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Book Description

This unique book describes the latest information in the fundamental understanding of the biophysics and biochemistry of articular cartilage using the state-of-the-art practices in NMR and MRI. This is the first book of its kind, written by physicists and chemists on this important tissue, whose degradation contributes to osteoarthritis and related joint diseases. Connecting the fundamental science with the clinical imaging applications, the experts Editors provide an authoritative addition to the literature. Ideal for practising physical scientists and radiologists with an interest in the fundamental science as well as instrument manufacturers and clinical researchers working with articular cartilage.



Magnetic Resonance Imaging in Tissue Engineering

Author : Mrignayani Kotecha

Publisher : John Wiley & Sons

Page : 485 pages

File Size : 13,59 MB

Release : 2017-02-21

Category : Technology & Engineering

ISBN : 1119193230

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Book Description

Magnetic Resonance Imaging in Tissue Engineering provides a unique overview of the field of non-invasive MRI assessment of tissue engineering and regenerative medicine Establish a dialogue between the tissue-engineering scientists and imaging experts and serves as a guide for tissue engineers and biomaterial developers alike Provides comprehensive details of magnetic resonance imaging (MRI) techniques used to assess a variety of engineered and regenerating tissues and organs Covers cell-based therapies, engineered cartilage, bone, meniscus, tendon, ligaments, cardiovascular, liver and bladder tissue engineering and regeneration assessed by MRI Includes a chapter on oxygen imaging method that predominantly is used for assessing hypoxia in solid tumors for improving radiation therapy but has the ability to provide information on design strategies and cellular viability in tissue engineering regenerative medicine



Biophysics of Molecular Chaperones

Author : Sebastian Hiller

Publisher : Royal Society of Chemistry

Page : 344 pages

File Size : 33,32 MB

Release : 2023-11-01

Category : Science

ISBN : 1839165995

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Book Description

Molecular chaperones are critical to control protein quality in all living cells. Understanding chaperone function at the atomic level, and in particular its mode of interaction with client proteins, is crucial to understanding the fundamental roles chaperones play in biology. This book fills a gap in the literature by comprehensively summarizing and discussing new advanced experimental techniques for their analysis. Providing a comprehensive overview of advanced biophysical methods for the characterization of molecular mechanisms of molecular chaperones, the majority of the contributions are NMR methodology. This is the method of choice for atomic resolution studies of such systems. Additional notable biophysical approaches are considered to present all relevant current developments in exploring chaperone function and the transient and dynamic interactions with their client proteins. The book is targeted at both current practitioners of structural biology and biophysical chemistry and scientists who are interested in entering the field. It could be useful for graduate students as supplementary reading.



NMR and MRI of Gels

Author : Yves De Deene

Publisher : Royal Society of Chemistry

Page : 426 pages

File Size : 13,75 MB

Release : 2020-07-07

Category : Science

ISBN : 1788019202

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Book Description

Gels are used in a large variety of commercial and scientific products from drug delivery systems and food science to biomedical sensors. They also are invaluable in MRI physics research where they mimic biological tissue and in radiotherapy quality assurance where they are used to capture the three dimensional radiation dose distribution. This unique book discusses the state-of-the-art of NMR and MRI techniques in studying the physics and chemistry of gel systems, in their application as MRI phantoms and as three dimensional radiation dosimeters. The first part of the book will cover the fundamental physical concepts of gels and the NMR techniques to study gel systems. The second part is dedicated to the application of gels in the life sciences and in the medical practice to validate radiotherapy and new MRI techniques. Filling the gap in literature, this volume provides the scientific reader with an extensive overview of possible techniques and methods to study the interesting properties and applications of gels. For the MRI researcher and medical physicist, the book will be a valuable resource in using gel phantoms for validating contemporary MRI techniques and radiotherapy treatments.



Essential Concepts in MRI

Author : Yang Xia

Publisher : John Wiley & Sons

Page : 372 pages

File Size : 29,90 MB

Release : 2022-05-31

Category : Medical

ISBN : 1119798213

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Book Description

ESSENTIAL CONCEPTS IN MRI A concise and complete introductory treatment of NMR and MRI Essential Concepts in MRI delivers the first comprehensive look at magnetic resonance imaging with a practical focus on nuclear magnetic resonance spectroscopy applications. The book includes the essential components of MRI and NMR and is written for anyone new to the field of MRI who seeks to gain a complete understanding of all four essential components of MRI: physics theory, instrumentation, spectroscopy, and imaging. Highly visual and including numerous full color figures that provide crucial graphical descriptions of key concepts discussed in the book, Essential Concepts in MRI includes discussions of quantitative and creative MRI, as well as spatial mapping in MRI and the effects of the field gradient and k-space imaging. The book also covers: A thorough introduction to essential concepts in nuclear magnetic resonance, including classical descriptions of NMR and quantum mechanical descriptions of NMR Comprehensive explorations of essential concepts in NMR instrumentation, including magnets, radio-frequency coils, transmitters, and receivers Practical discussions of essential concepts in NMR spectroscopy, including simple 1D spectroscopy, double resonance, and dipolar interactions in two-spin systems In-depth examinations of essential concepts in MRI, including the design of MRI pulse sequences and the elements of MRI instrumentation, with a special focus on quantitative MRI Essential Concepts in MRI is a must-read reference for upper-level undergraduate and postgraduate students in the physical and medical sciences, especially radiology, MRI, and imaging courses. It is also essential for students and researchers in the biomedical sciences and engineering.



NMR and MRI of Electrochemical Energy Storage Materials and Devices

Author : Yong Yang

Publisher : Royal Society of Chemistry

Page : 573 pages

File Size : 34,99 MB

Release : 2021-06-21

Category : Science

ISBN : 1788018486

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Book Description

The aim of this book is to introduce the use of NMR and MRI methods for investigating electrochemical storage materials and devices to help both NMR spectroscopists entering the field of batteries and battery specialists seeking diagnostic methods for material and device degradation.



Integrated Structural Biology

Author : Tatyana Polenova

Publisher : Royal Society of Chemistry

Page : 349 pages

File Size : 22,45 MB

Release : 2023-12-08

Category : Science

ISBN : 1837670161

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Book Description

Modern research in biology increasingly relies on multiple techniques for describing structures and mechanisms. This book provides an overview of the contemporary integrated biology approaches for solving structures and understanding mechanisms of complex biological systems. It includes several methodology chapters discussing the current developments in the areas of cryo-electron microscopy (EM) and cryo-electron tomography (ET), computational biophysics, solution NMR spectroscopy, solid-state NMR spectroscopy and dynamic nuclear polarization (DNP), electron paramagnetic resonance (EPR), (photo-)chemically induced dynamic nuclear polarization (CIDNP), X-ray crystallography and small-angle X-ray and neutron scattering (SAXS/SANS). Several subsequent chapters demonstrate how these methods are used in synergy to address problems at the forefront of structural biology, with particular emphasis on examples where individual techniques are insufficient. Examples of biological systems include membrane proteins, viral protein assemblies, cytoskeleton protein assemblies, photosynthetic reaction centers, large enzyme complexes and whole cells. The book is targeted to both the current practitioners of structural biology and scientists who are interested in entering the fields of structural biology or biophysical chemistry.



Physical Principles of Chirality in NMR

Author : Piotr Garbacz

Publisher : Royal Society of Chemistry

Page : 268 pages

File Size : 27,49 MB

Release : 2024-09-20

Category : Science

ISBN : 1839169591

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Book Description

How can we study one of the most elusive molecular properties, chirality, using nuclear interactions with the magnetic field that are apparently insensitive to handedness? This book answers this question from the physicochemical point of view by providing a clear, coherent, and comprehensive review of methods used in NMR studies of chirality. Presented arguments based on fundamental physical and chemical laws and in-depth descriptions of new methods utilizing purely physical interactions are mainly addressed to spectroscopists in both academia and industry. The introductory chapters provide the reader with the basics of NMR spectroscopy as a tool for the study of chiral compounds, and those more interested in the methods of chiral discrimination will benefit from the brief description of their common points and reasons why some of them may or may not work. In the following chapters, the book shows rapid progress in a newly emerging field of chirality-sensitive NMR, in particular, a search for effects that give direct information about the absolute configuration of a molecule.



NMR Spectroscopy for Probing Functional Dynamics at Biological Interfaces

Author : Anirban Bhunia

Publisher : Royal Society of Chemistry

Page : 733 pages

File Size : 47,61 MB

Release : 2022-08-17

Category : Science

ISBN : 1839162090

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Book Description

Providing a comprehensive amalgamation of the scattered knowledge of how to apply high-resolution NMR techniques to biomolecular systems, this book will break down the conventional stereotypes in the use of NMR for structural studies.



Magnetic Resonance and its Applications in Drug Formulation and Delivery

Author : Michael D Mantle

Publisher : Royal Society of Chemistry

Page : 390 pages

File Size : 16,55 MB

Release : 2024-03-27

Category : Science

ISBN : 1839160020

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Book Description

This book details the latest research and development in the use of magnetic resonance imaging and spectroscopy as tools to give quantitative insights concerning late stage pharmaceutical formulation, tablet manufacturing and drug dissolution behaviour. The book combines different facets of magnetic resonance and highlights the use of spatial resolution (MRI) and how this adds to the knowledge base to further our understanding of the microscopic physicochemical processes occurring during drug release from solid dosage forms. New topics, that have not been thoroughly reviewed elsewhere, are covered including the applications of solution state magnetic resonance in process scale up, reaction monitoring/understanding and process analytical technologies (PAT); dissolution testing; and counterfeit analysis. Solid state NMR and its role in understanding phase separation in dispersions, polymorphism and crystallography are included and magnetic resonance imaging and its use in assessing tablet dissolution performance, mass transport and mixing in hot melt extrusion (HME) are covered. Focusing on late stage development rather than molecular drug discovery provides a unique approach and the book will appeal to a diversity of disciplines using spectroscopy for study. Aimed at researchers in drug development, manufacture and formulation in both industry (pharmaceutical companies) and academia (pharmacy program), it includes examples, where appropriate, of studies on commercially available pharmaceutical products.