Biodefense in the Age of Synthetic Biology


Book Description

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.




Barriers to Bioweapons


Book Description

In both the popular imagination and among lawmakers and national security experts, there exists the belief that with sufficient motivation and material resources, states or terrorist groups can produce bioweapons easily, cheaply, and successfully. In Barriers to Bioweapons, Sonia Ben Ouagrham-Gormley challenges this perception by showing that bioweapons development is a difficult, protracted, and expensive endeavor, rarely achieving the expected results whatever the magnitude of investment. Her findings are based on extensive interviews she conducted with former U.S. and Soviet-era bioweapons scientists and on careful analysis of archival data and other historical documents related to various state and terrorist bioweapons programs.Bioweapons development relies on living organisms that are sensitive to their environment and handling conditions, and therefore behave unpredictably. These features place a greater premium on specialized knowledge. Ben Ouagrham-Gormley posits that lack of access to such intellectual capital constitutes the greatest barrier to the making of bioweapons. She integrates theories drawn from economics, the sociology of science, organization, and management with her empirical research. The resulting theoretical framework rests on the idea that the pace and success of a bioweapons development program can be measured by its ability to ensure the creation and transfer of scientific and technical knowledge. The specific organizational, managerial, social, political, and economic conditions necessary for success are difficult to achieve, particularly in covert programs where the need to prevent detection imposes managerial and organizational conditions that conflict with knowledge production.




The Soviet Biological Weapons Program


Book Description

This is the first attempt to understand the full scope of the USSR’s offensive biological weapons research, from inception in the 1920s. Gorbachev tried to end the program, but the U.S. and U.K. never obtained clear evidence that he succeeded, raising the question whether the means for waging biological warfare could be present in Russia today.




Biohazard


Book Description

'We thought we had lived through the terror of a nuclear war, but something far more ominous was brewing in the Soviet Union - a biological Armageddon from which no one would escape. Dr Alibek has emerged from the world's deadliest labs to tell a story that is as important as it is chilling. Sometimes the truth is far worse than fiction. No one can afford not to read this book.' Robin Cook 'As the top scientist in the Soviet Union's biowarfare program and the inventor of the world's most powerful anthrax, Dr Ken Alibek has stunned the highest levels of the U.S. government with his revelations. Now, in a calm, compelling, utterly convincing voice, he tells the world what he knows. Modern biology is producing weapons that in killing power may exceed the hydrogen bomb. Ken Alibek describes them with the intimate knowledge of a top weaponeer.' Richard Preston, author of The Hot Zone




Bioweapons


Book Description

Bioweapons have been used throughout history. They are made from things in nature and are used to kill. Find out about several common germs and how they have been used as bioweapons. Engage your most struggling readers in grades 4-7¾with Red Rhino Nonfiction! This new series features high-interest topics in every content area. Visually appealing full-color photographs and illustrations, fun facts, and short chapters keep emerging readers focused. Written at a 1.5-1.9 readability level, these books include pre-reading comprehension questions and a 20-word glossary for comprehension support.




Bioweapon


Book Description

In the world of tomorrow peace reigns: but at a terrible price. The internet now binds people in a state of unified progress, achieved through a microchipped population who have been united in the face of destruction, and bent to the will of an insidious secret society who control every inch of the planet from the shadows. Those who have rejected the all-powerful New World Order are forced to flee to the most unliveable parts of the Earth, and are branded as rebels and secretly hunted to extinction. Their only hope lies in the incredible scientists who are at the forefront of the rebellion, and the deadly bioweapons they create. Meanwhile, Leah Sudeski, a London based private journalist, stumbles onto some shocking evidence that changes everything she has ever known about the peaceful' society she was born and raised in. Desperate for the truth she begins an impossible mission, aided by the rebels, in order to bring Truth and Freedom back to humanity.




The Arenaviridae


Book Description

In this volume, a distinguished international group of contributors present the latest molecular, organismal, and epidemiological research on arenaviruses. Their work will broaden both the clinician's and the researcher's knowledge of basic mechanisms of immunological tolerance, viral immunosuppression, the nature of protective immune responses to vaccination, and viral effects on cell functions.




Handbook on Biological Warfare Preparedness


Book Description

Handbook on Biological Warfare Preparedness provides detailed information on biological warfare agents and their mode of transmission and spread. In addition, it explains methods of detection and medical countermeasures, including vaccine and post-exposure therapeutics, with specific sections detailing diseases, their transmission, clinical signs and symptoms, diagnosis, treatment, vaccines, prevention and management. This book is useful reading for researchers and advanced students in toxicology, but it will also prove helpful for medical students, civil administration, medical doctors, first responders and security forces. As the highly unpredictable nature of any event involving biological warfare agents has given rise to the need for the rapid development of accurate detection systems, this book is a timely resource on the topic. - Introduces different bacterial and viral agents, including Ebola and other emerging threats and toxins - Discusses medical countermeasures, including vaccines and post-exposure therapeutics - Includes a comprehensive review of current methods of detection




Pathogens for War


Book Description

Pathogens for War explores how Canada and its allies have attempted to deal with the threat of germ warfare, one of the most fearful weapons of mass destruction, since the Second World War. In addressing this subject, distinguished historian Donald Avery investigates the relationship between bioweapons, poison gas, and nuclear devices, as well as the connection between bioattacks and natural disease pandemics. Avery emphasizes the crucially important activities of Canadian biodefence scientists – beginning with Nobel Laureate Frederick Banting – at both the national level and through cooperative projects within the framework of an elaborate alliance system. Delving into history through a rich collection of declassified documents, Pathogens for War also devotes several chapters to the contemporary challenges of bioterrorism and disease pandemics from both national and international perspectives. As such, readers will not only learn about Canada’s secret involvement with biological warfare, but will also gain new insights into current debates about the peril of bioweapons – one of today’s greatest threats to world peace.




Phantom Menace or Looming Danger?


Book Description

A call for a new way to assess bioweapon threats—recognizing the importance of the sociopolitical context of technological threats. The horrifying terrorist attacks on September 11, 2001, and the anthrax strikes that soon followed gave the United States new reason to fear unconventional enemies and atypical weapons. These fears have prompted extensive research, study, and planning within the U.S. military, intelligence, and policy communities regarding potential attacks involving biological weapons. In Phantom Menace or Looming Danger?, Kathleen M. Vogel argues for a major shift in how analysts assess bioweapons threats. She calls for an increased focus on the social and political context in which technological threats are developed. Vogel uses case studies to illustrate her theory: Soviet anthrax weapons development, the Iraqi mobile bioweapons labs, and two synthetic genomic experiments. She concludes with recommendations for analysts and policymakers to integrate sociopolitical analysis with data analysis, thereby making U.S. bioweapon assessments more accurate. Students of security policy will find her innovative framework appealing, her writing style accessible, and the many illustrations helpful. These features also make Phantom Menace or Looming Danger? a must-read for government policymakers and intelligence experts. “This is an engrossing book that exemplifies what STS can bring to broader issues of policymaking in the US and potentially beyond, and it is well worth reading.” —Carla Nappi, New Books in Science, Technology, and Society “Kathleen Vogel has authored one of the most important books written about biological weapons in recent years. . . . Vogel tackles head-on the conventional wisdom regarding the biological weapon (BW) threat, successfully, challenging assumptions that have gone largely unexamined by the broader biodefense community. . . . She also uncovers some deeper organizational and social forces that have shaped US intelligence and threat assessments since the end of international security, not just those with an interest in biodefense or intelligence. This, this book is a must-read for scholars and practitioners in the field of international security, not just those with an interest in biodefense or intelligence.” —Gregory D. Koblentz, Nonproliferation Review “Intriguing, original, and deeply informed. Focusing on potential threats, Vogel shows in engaging historical detail that technical problems are inherently social. She has made an important scholarly contribution to science and technology studies and to studies of intelligence. At the same time, she speaks directly to the policy world. The combination of depth of scholarship and practical implication is remarkable.” —Lynn Eden, Center for International Security and Cooperation, Freeman Spogli Institute for International Studies, Stanford University