Biodefense in the Age of Synthetic Biology


Book Description

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.




Barriers to Bioweapons


Book Description

In both the popular imagination and among lawmakers and national security experts, there exists the belief that with sufficient motivation and material resources, states or terrorist groups can produce bioweapons easily, cheaply, and successfully. In Barriers to Bioweapons, Sonia Ben Ouagrham-Gormley challenges this perception by showing that bioweapons development is a difficult, protracted, and expensive endeavor, rarely achieving the expected results whatever the magnitude of investment. Her findings are based on extensive interviews she conducted with former U.S. and Soviet-era bioweapons scientists and on careful analysis of archival data and other historical documents related to various state and terrorist bioweapons programs.Bioweapons development relies on living organisms that are sensitive to their environment and handling conditions, and therefore behave unpredictably. These features place a greater premium on specialized knowledge. Ben Ouagrham-Gormley posits that lack of access to such intellectual capital constitutes the greatest barrier to the making of bioweapons. She integrates theories drawn from economics, the sociology of science, organization, and management with her empirical research. The resulting theoretical framework rests on the idea that the pace and success of a bioweapons development program can be measured by its ability to ensure the creation and transfer of scientific and technical knowledge. The specific organizational, managerial, social, political, and economic conditions necessary for success are difficult to achieve, particularly in covert programs where the need to prevent detection imposes managerial and organizational conditions that conflict with knowledge production.




The Soviet Biological Weapons Program


Book Description

This is the first attempt to understand the full scope of the USSR’s offensive biological weapons research, from inception in the 1920s. Gorbachev tried to end the program, but the U.S. and U.K. never obtained clear evidence that he succeeded, raising the question whether the means for waging biological warfare could be present in Russia today.




Germs


Book Description

In this “engrossing, well-documented, and highly readable” (San Francisco Chronicle) New York Times bestseller, three veteran reporters draw on top sources inside and outside the U.S. government to reveal Washington's secret strategies for combating germ warfare and the deadly threat of biological and chemical weapons. Today Americans have begun to grapple with two difficult truths: that there is no terrorist threat more horrifying—and less understood—than germ warfare, and that it would take very little to mount a devastating attack on American soil. Featuring an inside look at how germ warfare has been waged throughout history and what form its future might take (and in whose hands), Germs reads like a gripping detective story told by fascinating key figures: American and Soviet medical specialists who once made germ weapons but now fight their spread, FBI agents who track Islamic radicals, the Iraqis who built Saddam Hussein's secret arsenal, spies who travel the world collecting lethal microbes, and scientists who see ominous developments on the horizon. With clear scientific explanations and harrowing insights, Germs is a vivid, masterfully written—and timely—work of investigative journalism.




Bioweapons


Book Description

Bioweapons have been used throughout history. They are made from things in nature and are used to kill. Find out about several common germs and how they have been used as bioweapons. Engage your most struggling readers in grades 4-7¾with Red Rhino Nonfiction! This new series features high-interest topics in every content area. Visually appealing full-color photographs and illustrations, fun facts, and short chapters keep emerging readers focused. Written at a 1.5-1.9 readability level, these books include pre-reading comprehension questions and a 20-word glossary for comprehension support.




Biohazard


Book Description

'We thought we had lived through the terror of a nuclear war, but something far more ominous was brewing in the Soviet Union - a biological Armageddon from which no one would escape. Dr Alibek has emerged from the world's deadliest labs to tell a story that is as important as it is chilling. Sometimes the truth is far worse than fiction. No one can afford not to read this book.' Robin Cook 'As the top scientist in the Soviet Union's biowarfare program and the inventor of the world's most powerful anthrax, Dr Ken Alibek has stunned the highest levels of the U.S. government with his revelations. Now, in a calm, compelling, utterly convincing voice, he tells the world what he knows. Modern biology is producing weapons that in killing power may exceed the hydrogen bomb. Ken Alibek describes them with the intimate knowledge of a top weaponeer.' Richard Preston, author of The Hot Zone




Biological Weapons


Book Description

Until the events of September 11 and the anthrax attacks of 2001, biological weapons had never been a major public concern in the United States. Today, the possibility of their use by terrorists against Western states looms large as an international security concern. In Biological Weapons, Jeanne Guillemin provides a highly accessible and compelling account of the circumstances under which scientists, soldiers, and statesmen were able to mobilize resources for extensive biological weapons programs and also analyzes why such weapons, targeted against civilians, were never used in a major conflict. This book is essential for understanding the relevance of the historical restraints placed on the use of biological weapons for today's world. It serves as an excellent introduction to the problems biological weapons pose for contemporary policymakers and public officials, particularly in the United States. How can we best deter the use of such weapons? What are the resulting policies of the Department of Homeland Security? How can we constrain proliferation? Jeanne Guillemin wisely points out that these are vitally important questions for all Americans to consider and investigate—all the more so because the development of these weapons has been carried out under a veil of secrecy, with their frightening potential open to exploitation by the media and government. Public awareness through education can help calm fears in today's tension-filled climate and promote constructive political action to reduce the risks of a biological weapons catastrophe. Biological Weapons is required reading for every concerned citizen, government policymaker, public health official, and national security analyst who wants to understand this complex and timely issue.




Toxicologic Assessment of the Army's Zinc Cadmium Sulfide Dispersion Tests


Book Description

During the 1950s and 1960s, the U.S. Army conducted atmospheric dispersion tests in many American cities using fluorescent particles of zinc cadmium sulfide (ZnCdS) to develop and verify meteorological models to estimate the dispersal of aerosols. Upon learning of the tests, many citizens and some public health officials in the affected cities raised concerns about the health consequences of the tests. This book assesses the public health effects of the Army's tests, including the toxicity of ZnCdS, the toxicity of surrogate cadmium compounds, the environmental fate of ZnCdS, the extent of public exposures from the dispersion tests, and the risks of such exposures.




Living Weapons


Book Description

"Biological weapons are widely feared, yet rarely used. Biological weapons were the first weapon prohibited by an international treaty, yet the proliferation of these weapons increased after they were banned in 1972. Biological weapons are frequently called 'the poor man's atomic bomb,' yet they cannot provide the same deterrent capability as nuclear weapons. One of my goals in this book is to explain the underlying principles of these apparent paradoxes."—from Living Weapons Biological weapons are the least well understood of the so-called weapons of mass destruction. Unlike nuclear and chemical weapons, biological weapons are composed of, or derived from, living organisms. In Living Weapons, Gregory D. Koblentz provides a comprehensive analysis of the unique challenges that biological weapons pose for international security. At a time when the United States enjoys overwhelming conventional military superiority, biological weapons have emerged as an attractive means for less powerful states and terrorist groups to wage asymmetric warfare. Koblentz also warns that advances in the life sciences have the potential to heighten the lethality and variety of biological weapons. The considerable overlap between the equipment, materials and knowledge required to develop biological weapons, conduct civilian biomedical research, and develop biological defenses creates a multiuse dilemma that limits the effectiveness of verification, hinders civilian oversight, and complicates threat assessments. Living Weapons draws on the American, Soviet, Russian, South African, and Iraqi biological weapons programs to enhance our understanding of the special challenges posed by these weapons for arms control, deterrence, civilian-military relations, and intelligence. Koblentz also examines the aspirations of terrorist groups to develop these weapons and the obstacles they have faced. Biological weapons, Koblentz argues, will continue to threaten international security until defenses against such weapons are improved, governments can reliably detect biological weapon activities, the proliferation of materials and expertise is limited, and international norms against the possession and use of biological weapons are strengthened.




Baseless


Book Description

“Staggeringly good.” —Counterpunch A major new work, a hybrid of history, journalism, and memoir, about the modern Freedom of Information Act—FOIA—and the horrifying, decades-old government misdeeds that it is unable to demystify, from one of America's most celebrated writers Eight years ago, while investigating the possibility that the United States had used biological weapons in the Korean War, Nicholson Baker requested a series of Air Force documents from the early 1950s under the provisions of the Freedom of Information Act. Years went by, and he got no response. Rather than wait forever, Baker set out to keep a personal journal of what it feels like to try to write about major historical events in a world of pervasive redactions, witheld records, and glacially slow governmental responses. The result is one of the most original and daring works of nonfiction in recent memory, a singular and mesmerizing narrative that tunnels into the history of some of the darkest and most shameful plans and projects of the CIA, the Air Force, and the presidencies of Harry Truman and Dwight Eisenhower. In his lucid and unassuming style, Baker assembles what he learns, piece by piece, about Project Baseless, a crash Pentagon program begun in the early fifties that aimed to achieve "an Air Force-wide combat capability in biological and chemical warfare at the earliest possible date." Along the way, he unearths stories of balloons carrying crop disease, leaflet bombs filled with feathers, suicidal scientists, leaky centrifuges, paranoid political-warfare tacticians, insane experiments on animals and humans, weaponized ticks, ferocious propaganda battles with China, and cover and deception plans meant to trick the Kremlin into ramping up its germ-warfare program. At the same time, Baker tells the stories of the heroic journalists and lawyers who have devoted their energies to wresting documentary evidence from government repositories, and he shares anecdotes from his daily life in Maine feeding his dogs and watching the morning light gather on the horizon. The result is an astonishing and utterly disarming story about waiting, bureaucracy, the horrors of war, and, above all, the cruel secrets that the United States government seems determined to keep forever from its citizens.