Bone Grafts And Bone Substitutes: Basic Science And Clinical Applications


Book Description

This book provides the latest updates on the major challenges of bridging large bone defects, where options range from autografts, “tissue engineered bone”, biomaterials (hydroxyapatite, polycaprolactone and third generation biomaterials) to prostheses. Emphasis has been made on bone tissue engineering, the current state-of-the-art in this field, problems encountered with cell culture technology, scaffolds and bone growth factors (including genomics) and the use of gene therapy for the application of bone growth factors. Attention has also been given to the use of bone autografts. It also covers the use of biomaterials and prostheses as other options for reconstruction. Clinical applications, in addition to the basic science, are also included throughout the discussions.




Bone Regeneration and Repair


Book Description

This collection of articles by leading orthopedic and craniofacial surgeons and researchers comprehensively reviews the biology of bone formation and repair, the basic science of autologous bone graft, allograft, bone substitutes, and growth factors, and explore their clinical application in patients with bone repair problems.




Bone Grafts & Bone Substitutes


Book Description

Edited by a recognized authority in craniofacial surgery, this book provides comprehensive coverage of bone grafts and substitutes. International contributors discuss the basic science of bone graft healing, including different forms of bone grafts, applications by surgical subspecialty, radiographic assessment, critical sites for new bone formation, and more. Plus, contains clinical and research-oriented information on bone substitutes, including composite grafts, metallic implants, implant interface, computer-assisted fabrication of bone grafts, and much more.




Clinical Applications of Bone Allografts and Substitutes


Book Description

Although bone allografts were first utilized by McEwen in orthopaedic surgery in 1881, progress since then has been sporadic. With the growth of tissue banks and the greater availability of safe and sterile bone grafts, the pace has now quickened; in 2004, more than one million such grafts were used in the USA alone. However, the practice generally remained a OC cottage industryOCO well into the latter part of the 20th century. This volume provides an international expert evaluaton of the current use of bone, bone substitutes and related allografts, and describes up-to-date practices and clinical results in particular procedures. It will provide a ready reference for readers wishing to carry out an initial survey of the subject."




Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration


Book Description

This book integrates the current basic and clinical knowledge in the area of biophysical stimulation of osteoblast for in vitro and in vivo live bone generation. This innovative methodology and its applications are presented and discussed in several clinical conditions: treatment of fracture nonunion, spine stabilization, bone replacement after tumor resections, stabilization of failed joint endoprostheses in revision surgery and in treatment of bone loss (osteoporosis and osteopenia). The author analyses different types of biophysical stimulation of osteoblasts for bone regeneration, e.g. mechanical (static and alternating, including distraction osteogenesis), electromagnetic (pulsed, alternating, static), light (at different spectrum range, including laser), acoustic (including ultrasound), RF etc. Moreover, he summarizes and discusses the most significant findings for in vitro bone generation and its resulting clinical use as autologous bone graft without surgical morbidity. Reflecting the author's extensive experience this book is an excellent source of knowledge and a valuable aid to clinical practice for all orthopedic surgeons, fellows, and researchers wanting to gain insights into this promising field. .




Bone Grafts


Book Description

Autogenous bone grafting continues to be the gold standard for treating osseous defects and stimulating new bone formation. Harvesting of autogenous bone grafts can be associated with a significant risk of complications. Also, the amount of bone graft that can be harvested is limited. Therefore, efforts have been made to develop different bone graft substitutes such as: allografts, synthetic bone substitutes, platelet-rich plasma, bone marrow aspirate, Bone Morphogenetic Proteins, Vascular Endothelial Growth Factor, Fibroblast Growth Factors, parathyroid hormone and Wnt signalling. Some techniques with the use of bone autografts in orthopaedics and dentistry, complications associated with the harvest of autografts, the use of other alternatives, their biology and clinical applications and a look into research into new materials and technologies aiming to improve this field in medicine will be discussed in this book.




Translating Biomaterials for Bone Graft


Book Description

Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.




Mineralized Collagen Bone Graft Substitutes


Book Description

Mineralized Collagen Bone Graft Substitutes presents a comprehensive study of biomimetic mineralized collagen, synthesized in vitro, a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the clinical use of this novel material, the book provides a complete examination, from bench to bedside. Chapters discuss natural bone and familiar biomaterials for bone repair, the preparation and safety of mineralized collagen, products made of mineralized collagen, and present clinical case studies. This book is an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. Provides a deep analysis of synthetic collagen, from bench to bedside Systematically examines the structure, principles, properties, biomimetic synthesis and characterization of mineralized collagen for bone repair Includes case studies that look at a range of clinical bone repair applications of Mineralized collagen and their clinical results




The Use of Bone Substitutes in Spine Surgery


Book Description

Recent developments in surgical techniques have led to an increased demand for bone stock. Fusion enhancement, bone-void filling in tumor surgery and trauma are only a few examples. Autologous bone can be considered as the most successful bone graft material, and constitutes the accepted 'gold standard', as it combines all the properties required from the bone graft. In this book a 'state of the art in bone substitution for the spine' is presented. The general principles of bone biology and bone healing are outlined, as are recent advances in understanding and influencing bone formation. A variety of substitutes are described and compared.




Bone graft substitutes


Book Description