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Boorman's Pathology of the Rat

Author : Andrew W. Suttie

Publisher : Academic Press

Page : 750 pages

File Size : 33,40 MB

Release : 2017-12-01

Category : Medical

ISBN : 0123914892

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Book Description

Boorman's Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. - Contains full, four color photographs from the NTP archive and database and coverage of all rat strains - Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes - Includes comprehensive and detailed background incidence data - Presents detailed descriptive content regarding changes in rat models during research



Pathology of the Fischer Rat

Author : Gary A. Boorman

Publisher : San Diego : Academic Press

Page : 580 pages

File Size : 41,71 MB

Release : 1990

Category : Medical

ISBN : 9780121156404

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Book Description

Studies in rodents of the toxicity and carcinogenicity of drugs, agricultural agents (e.g., pesticides and herbicides), environmental pollutants, industrial agents (e.g., solvents and intermediates), and other chemicals are the cornerstone of human safety evaluations in the development, use, and/or regulation of these agents. Those who perform the pathological evaluations from these studies need standard diagnostic criteria and pathology terminology. Pathology of the Fischer Rat is a comprehensive pathology reference text on the Fischer 344 rat, the strain widely used for safety evaluations and almost exclusively by the National Toxicology Program.****Every chapter follows the same format of introduction; embryology; normal anatomy, histology, and physiology; and congenital, degenerative, inflammatory and vascular, hyperplastic and neoplastic, miscellaneous, and toxicological lesions. The spectrum of spontaneous and treatment-related, neoplastic and nonneoplastic lesions found in each tissue is described and photographed.****The text is useful not only to pathologists but also to investigators from a variety of disciplines who use the rat as an animal model. It will also prove valuable to toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to promulgation of meaningful regulations.



Nutrient Requirements of Laboratory Animals,

Author : National Research Council

Publisher : National Academies Press

Page : 188 pages

File Size : 38,56 MB

Release : 1995-02-01

Category : Science

ISBN : 0309051266

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Book Description

In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.



The Laboratory Rat, Second Edition

Author : Patrick Sharp

Publisher : CRC Press

Page : 403 pages

File Size : 34,96 MB

Release : 2012-12-11

Category : Medical

ISBN : 1439829861

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Book Description

Rats have long been recognized as a valuable biomedical research model, notably in the investigation of aging, toxicology, addiction, and common human diseases such as diabetes and hypertension. In many instances, individuals conducting such research studies are charged with important responsibilities, including animal facility management, animal husbandry, veterinary care, regulatory compliance, and various experimental methodologies. With the advent of genetic manipulations and biomedical research technological advances such as bioimaging, the versatility and usefulness of the rat as an animal model has soared. The Laboratory Rat, Second Edition captures the multiple advances in this important animal model’s husbandry, veterinary care, and experimental methodology. This edition features augmented, expanded, and novel information on biology, anesthesia, analgesia, and experimental techniques benefiting personnel working with rats—from the animal care staff to the researcher and everyone in between. The book is also extremely useful to institutional animal care and use program supporters and elements, including animal care and use committees, institutional officials, occupational health and safety professionals, veterinary technicians, and veterinarians.



Comparative Anatomy and Histology

Author : Piper M. Treuting

Publisher : Academic Press

Page : 475 pages

File Size : 18,20 MB

Release : 2012

Category : Medical

ISBN : 0123813611

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Book Description

1. Introduction -- 2. Phenotyping -- 3. Necropsy and histology -- 4. Mammary Gland -- 5. Skeletal System -- 6. Nose, sinus, pharynx and larynx -- 7. Oral cavity and teeth -- 8. Salivary glands -- 9. Respiratory -- 10. Cardiovascular -- 11. Upper GI -- 12. Lower GI -- 13. Liver and gallbladder -- 14. Pancreas -- 15. Endocrine System -- 16. Urinary System -- 17. Female Reproductive System -- 18. Male Reproductive System -- 19. Hematopoietic and Lymphoid Tissues -- 20. Nervous System -- 21. Special senses, eye -- 22. Special senses, ear -- 23. Skin and adnexa -- Index.



Pathology of the Mouse

Author : Robert R. Maronpot

Publisher :

Page : 699 pages

File Size : 23,80 MB

Release : 1999-01-01

Category : Science

ISBN : 9781889899022

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Background Lesions in Laboratory Animals E-Book

Author : Elizabeth Fiona McInnes

Publisher : Elsevier Health Sciences

Page : 141 pages

File Size : 29,32 MB

Release : 2011-10-24

Category : Medical

ISBN : 0702049247

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Book Description

Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. - over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits - a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals - a chapter on common artifacts that may be observed in histological glass slides - extensive references to each lesion described - aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies



The Laboratory Rat

Author : Henry J. Baker

Publisher :

Page : 464 pages

File Size : 17,52 MB

Release : 1979

Category : Medical

ISBN : 9780120749010

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Saunders Comprehensive Veterinary Dictionary E-Book

Author : Virginia P. Studdert

Publisher : Elsevier Health Sciences

Page : 1340 pages

File Size : 39,45 MB

Release : 2011-12-09

Category : Medical

ISBN : 0702047449

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Book Description

The new edition of Blood’s classic Comprehensive Veterinary Dictionary has been completely redesigned, revised and updated for today’s veterinary team. Now with a wide range of superb full-colour illustrations, well over 60,000 main and subentries including large animals, small animals and exotics, and an all-new, user-friendly format, the fourth edition offers the most comprehensive dictionary reference in the field. Comprehensive text covering the whole range of veterinary medicine Classic authoritative reference work Valuable and accessible appendices for instant access to key information at a glance Well over 60,000 main entries and subentries Extensive contributions from internationally acknowledged expert consultants New for this edition Over 1,000 colour illustrations to aid further understanding of disease processes and important terminology Pronunciation of key terms Brand new design and format to help find key information at a glance Extensive revision, clarification and focussing of entries to reflect current practice



Toxicologic Pathology for Non-Pathologists

Author : Thomas J. Steinbach

Publisher : Springer Nature

Page : 919 pages

File Size : 29,91 MB

Release : 2019-10-31

Category : Medical

ISBN : 1493997777

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Book Description

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.