Author : Jan Willem Mathijs Hoekstra
Publisher :
Page : 183 pages
File Size : 31,71 MB
Release : 2013
Category :
ISBN : 9789461917911
Author : S.S. Nanda
Publisher : CRC Press
Page : 180 pages
File Size : 48,45 MB
Release : 2024-05-15
Category : Technology & Engineering
ISBN : 1040021263
Calcium phosphate materials are used in many medical and dental applications. Advanced Synthesis and Medical Applications of Calcium Phosphates covers the structure, chemistry, synthesis, and properties of both natural and synthetic calcium-based biomaterials and details a variety of medical applications. Depicts the latest advances in using calcium phosphates in bone regeneration and tissue engineering Includes the latest generation of regenerative biomaterials with an integrated perspective combining both research and clinical issues Provides an understanding of the clinical targets and requirements for regenerative medicine Detailing fundamentals through applications, this book helps biomaterials researchers to better understand the clinical targets and requirements for use of these materials for optimal synthesis and development.
Author : Andy H. Choi
Publisher : Springer Nature
Page : 89 pages
File Size : 38,70 MB
Release : 2023-09-11
Category : Science
ISBN : 9819955068
This book provides in-depth assessment on the latest clinical advances in multifunctional calcium phosphate nanocoatings and its influence on bone regeneration and early healing following implantation. A greater emphasis will be placed on the use of nanocomposite coatings to deliver biological materials such as mesenchymal stem cells, growth factors, bone morphogenetic and extracellular matrix proteins, and pharmaceutics such as simvastatin to improve and promote bone growth as well as reducing the timeframe needed for implant integration in both healthy and osteoporotic patients. The content of the book caters to clinical practitioners and researchers working in the field of biomaterials for bone regeneration.
Author : Changsheng Liu
Publisher : Springer
Page : 632 pages
File Size : 45,23 MB
Release : 2017-10-20
Category : Technology & Engineering
ISBN : 9811059756
This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.
Author : Michael R. Mucalo
Publisher : MDPI
Page : 176 pages
File Size : 50,63 MB
Release : 2020-12-15
Category : Science
ISBN : 3039282646
Research into the use of calcium phosphates in the development and clinical application of biomedical materials has been a significantly diverse activity conducted by a wide range of scientists, engineers, and medical practitioners, among others. The field of research in this area can, hence, be truly defined as interdisciplinary, and much interesting work leading to imaginative and innovative solutions for the improvement of health outcomes continues to be generated. It has been the intention of this Special Issue to summarise a number of current topical research advances in this area, as well as to review the important area of calcium phosphate-based biomaterials, namely, composites of hydroxyapatite with carbon-based materials. The scientific papers contained in this Special Issue report on advances in the areas of dental-based materials science, bone cements, use of biomaterials created from natural sources, influences of added agents such as adipose stem cells and statins on bioactivity as well as surface influences on electrical potential of biomaterials and uses of glow discharge methods to remove impurities from biomaterial surfaces.
Author :
Publisher : ScholarlyEditions
Page : 161 pages
File Size : 10,27 MB
Release : 2012-01-09
Category : Science
ISBN : 1464926247
Calcium Phosphates: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Calcium Phosphates in a concise format. The editors have built Calcium Phosphates: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Calcium Phosphates in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Calcium Phosphates: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Daniel O. Costa
Publisher :
Page : 458 pages
File Size : 17,27 MB
Release : 2012
Category :
ISBN :
Bone defects are a prevalent problem in orthopedics and dentistry. Calcium phosphate-based coatings and nanocomposites offer unique solutions towards producing scaffolds with suitable physical, mechanical and biological properties for bone regeneration. We developed a novel method to synthesize hydroxyapatite (HA) particles with high aspect ratio using sol-gel chemistry and hydrothermal treatment. We obtained tunable pure-phase carbonated-HA in the form of micro/nanorods and nanowires (diameters 25-800 nm). To mimic the structure of bone, HA nanowires were homogenously mixed within poly( -caprolactone) (PCL) to produce nanocomposites with improved mechanical properties as determined by uniaxial tensile testing. Surface chemistry and topography of biomaterials play prominent roles in regulating cell adhesion and differentiation. Bone-like apatite coatings, produced by incubating materials in a simulated body fluid (SBF), improve the osteoconductivity of scaffold materials. However, few studies have controlled the surface topography of biomimetic HA. We assessed the effect of SBF ion concentration and soaking time on the surface properties of apatite coatings. Calcium phosphates such as carbonated-HA with similar chemical composition and stiffness were deposited onto PCL films. Characterization of these coatings revealed an increase in topographical complexity and surface roughness with increasing ion concentration of SBF and soaking time. To investigate their potential application in bone regeneration, we studied the influence of topography of biomimetic HA coatings on the behavior of osteoblasts and osteoclasts in vitro. Osteoblast attachment and differentiation were significantly greater iv when cultured on rougher HA surfaces (Ra 2̃ m) than on smoother topographies (Ra 1̃ m). In contrast, activity of tartrate-resistant acid phosphatase (an osteoclast marker) was greater on smoother than on rougher HA surfaces. Furthermore, osteoclastic resorption lacunae were found exclusively on smoother HA coatings. Inhibition of resorption on rougher HA surfaces was associated with disruption of filamentous actin sealing zones. In conclusion, HA coatings can be prepared with different topographies, which regulate responses of osteoblasts and osteoclasts. Thus, it may be possible to design HA-polymer composites and HA-coated polymers with physical, mechanical and biological properties suitable for tissue engineering. By modulating topography, rates of bone formation and biodegradation could be tailored for specific applications in orthopedics and dentistry.
Author : Gerard Insley
Publisher : Woodhead Publishing
Page : 374 pages
File Size : 49,66 MB
Release : 2019-11-20
Category : Medical
ISBN : 0081025122
Octacalcium Phosphate Biomaterials: Past, Present and Future is a comprehensive study of octacalcium phosphate (OCP), a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the use of OCP as a scaffold material, this book explores its potential to deliver improved clinical results. Early chapters in the book discuss OCP's effects on bone cell activity, cellular interactions and their role in bone formation, repair and replacement. Later chapters cover topics such as drug delivery, synthesis methodologies and future analysis techniques. This will be an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. OCP is known to be a pre-cursor to hydroxyapatite in the human biomineralization process that forms bone and tooth enamel. Research studies that have emerged in recent years suggest OCP's tremendous potential as a bioactive material. Contains comprehensive, up-to-date information on the basic science, including physical, chemical and biological properties Presents the clinical potential of octacalcium phosphate biomaterials Provides a reference point for new research and increased activity in the area of next generation smarter biomaterials for hard tissue repair and regeneration
Author : Zeeshan Sheikh
Publisher :
Page : pages
File Size : 12,78 MB
Release : 2014
Category :
ISBN :
"Synthetic bone graft substitutes are frequently used to fill defects with significant bone loss to prevent fibrous tissue ingrowth and loss of function. Bone grafts are often used to augment deficient alveolar ridges allowing placement of dental implants subsequent to prior bone loss. Although autografts, allografts and xenografts have been used and researched extensively, they have inherent limitations. To overcome these, synthetic alternatives, such as calcium phosphate cement-based biomaterials are being developed. Brushite and monetite are acidic calcium phosphates having similar chemical composition. However, their in vivo behavior differs in terms of resorption and bone response. Although brushite and monetite have been shown to resorb faster in vivo than hydroxyapatite (HA), a significant reduction in the rate of resorption occurs following phase conversion of brushite to insoluble HA. As such differences between bone grafts are attributed to material composition even though physical properties such as surface area and porosity invariably differ. This thesis focuses on determining the factors and mechanisms that makes these chemically similar materials behave differently in vivo. We produced brushite cement grafts and converted them to two types of monetite by using wet (autoclaving) and dry heat (under vacuum) dehydration which resulted in materials with differing physicochemical properties. These grafts were then aged in vitro using bovine serum and phosphate buffered saline (PBS) solutions, implanted subcutaneously, in femoral condyles and onlay grafted on calvaria. The dissolution, resorption and bone formation potential of these dicalcium phosphate cement grafts was assessed and compared. Also, we developed a new alkali ion (sodium and potassium) substituted calcium phosphate cement, reinforced with silica and set using phytic acid. The set cement blocks were aged in PBS solutions and their in vitro dissolution and degradation along with other physico-chemical properties was assessed.Results presented in this Ph.D thesis discuss and shed light on the fundamental yet not understood questions regarding the relative contributions from chemico- vs physico-biomaterial properties in graft resorption and bone regeneration. This will allow in future the preparation of improved calcium phosphate-based bone substitute grafts with potential to achieve higher clinical efficiency. " --
Author : K. de Groot
Publisher : CRC Press
Page : 152 pages
File Size : 10,54 MB
Release : 2018-01-18
Category : Science
ISBN : 1351078585
The first chapters are fundamental, in that the physical chemistry of calcium phosphate salts is discussed, along with mineralization (with emphasis on teeth) and remodelling of mineralized tissues. Thereafter follows a treatment of the influence of implants o surrounding hard tissues. This topic is followed by a chapter on preparation methods and biomechanical and biological aspects of calcium phosphate implants. In conclusion, two chapters are devoted to (possible) dental and medical applications. It is hoped that basic researchers can use the book in their efforts to improve this promising class of materials further, and that clinicians are inspired to define further possibilities and at least as important limitations.
