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Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

Author : Sadegh Babashah

Publisher : Springer

Page : 576 pages

File Size : 32,3 MB

Release : 2015-11-12

Category : Medical

ISBN : 3319210300

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Book Description

The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.



Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

Author : Sadegh Babashah

Publisher :

Page : pages

File Size : 48,79 MB

Release : 2015

Category :

ISBN : 9783319210315

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Book Description

The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.



Aesthetic Treatments for the Oncology Patient

Author : Paloma Tejero

Publisher : CRC Press

Page : 402 pages

File Size : 33,12 MB

Release : 2020-11-29

Category : Medical

ISBN : 1351395068

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Book Description

Physicians are increasingly recognizing that helping a cancer patient feel good about themselves and about their appearance can be of vital importance in giving them the emotional support and psychological resilience to survive and recover from the side-effects of disease and its treatment. Dermatologists and other aesthetic physicians are in a prime position to help a cancer patient recover lost volume, hydration, and pigmentation in skin, nails, and hair, as well as to advise on nutrition, prostheses, and complentary therapies. This pioneering volume will be an important resource bringing together the expertise in this area, with the practical detail a physician will need.



Pharmacotherapeutic Botanicals for Cancer Chemoprevention

Author : Manish Kumar

Publisher : Springer Nature

Page : 344 pages

File Size : 18,71 MB

Release : 2020-07-20

Category : Medical

ISBN : 9811559996

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Book Description

The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.



Oxford Textbook of Oncology

Author : David J. Kerr

Publisher : Oxford University Press

Page : 2837 pages

File Size : 20,79 MB

Release : 2016-01-28

Category : Medical

ISBN : 0191065110

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Book Description

Written and edited by internationally recognised leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.



Mesenchymal Stem Cell Derived Exosomes

Author : Yaoliang Tang

Publisher : Academic Press

Page : 287 pages

File Size : 43,72 MB

Release : 2015-09-02

Category : Science

ISBN : 0128004975

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Book Description

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. - Introduces the MSC-exosome mediated cell-cell communication - Covers the major functional benefits in current MSC-derived exosome studies - Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies



Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy

Author : Christopher D. Gregory

Publisher : Springer

Page : 260 pages

File Size : 26,52 MB

Release : 2016-08-24

Category : Medical

ISBN : 3319394061

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Book Description

This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.



The Breast E-Book

Author : Kirby I. Bland

Publisher : Elsevier Health Sciences

Page : 1439 pages

File Size : 44,4 MB

Release : 2017-06-29

Category : Medical

ISBN : 0323511872

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Book Description

Now in a single, convenient volume, The Breast: Comprehensive Management of Benign and Malignant Diseases, 5th Edition covers every clinically relevant aspect of the field: cancer, congenital abnormalities, hormones, reconstruction, anatomy and physiology, benign breast disease, and more. Building upon the strengths of previous editions, this updated volume by Drs. Kirby I. Bland, Edward M. Copeland III, V. Suzanne Klimberg, and William J Gradishar, includes the latest innovations in breast cancer detection and treatment in a practical, easy-to-use format ideal for today's surgeons. - Delivers step-by-step clinical guidance highlighted by superb illustrations that depict relevant anatomy and pathology, as well as medical and surgical procedures. - Reflects the collaborative nature of diagnosis and treatment among radiologists, pathologists, surgeons, oncologists, and other health care professionals who contribute to the management of patients with breast disease. - Offers the most comprehensive, up-to-date information on the diagnosis and management of, and rehabilitation following, surgery for benign and malignant diseases of the breast. - Covers the latest developments in receptor modulation, targeted monoclonal antibodies, evolving inhibitors with triple-negative disease, and more. - Discusses recent minimally invasive surgical techniques and new developments in oncoplastic breast conservation techniques. - Contains significant updates to the "Management of Systemic Disease" section that reflect the latest advances in chemotherapy, hormonal resistance, and therapy. - Includes links to real-time procedure videos and full-color procedural line drawings from the Klimberg Atlas of Breast Surgical Techniques on Expert Consult, providing expert visual guidance on how to execute key steps and techniques. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.



Stem Cells – From Hype to Real Hope

Author : Khawaja Husnain Haider

Publisher : Walter de Gruyter GmbH & Co KG

Page : 220 pages

File Size : 23,92 MB

Release : 2018-12-17

Category : Medical

ISBN : 3110587041

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Book Description

This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.



Glioblastoma: State of the Art and Future Perspectives

Author : Ghazaleh Tabatabai

Publisher :

Page : 784 pages

File Size : 13,9 MB

Release : 2020

Category :

ISBN : 9783039282616

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Book Description

Glioblastoma is an aggressive incurable primary tumor of the central nervous system. Median overall survival is in the range of 1.5 years even in selected clinical trials populations. Many features contribute to this therapeutic challenge including high intratumoral and intertumoral heterogeneity, resistance to therapy, migration and invasion, immunosuppression. With the access of novel highthroughput technologies, significant progress has been made to understand molecular and immunological signatures underlying the pathology of glioblastoma. Clinical trial designs have shifted from investigating broad “one-for-all” treatment approaches to precision oncology designs. The collection of contributions in this book aim at providing researchers and clinicians an update on different aspects of glioblastoma, i.e. progress in basic, preclinical and clinical research.