Cellular and Molecular Mechanisms in Experimental Pulmonary Fibrosis in Mice
Author : Ramon Morales Molina
Publisher :
Page : 270 pages
File Size : 48,23 MB
Release : 1994
Category : Pulmonary fibrosis
ISBN :
Author : Ramon Morales Molina
Publisher :
Page : 270 pages
File Size : 48,23 MB
Release : 1994
Category : Pulmonary fibrosis
ISBN :
Author : Chunheng Mo
Publisher : Frontiers Media SA
Page : 123 pages
File Size : 25,13 MB
Release : 2024-01-23
Category : Science
ISBN : 2832543251
Organ fibrosis seriously threatens human health. Globally, more than 30% of the diseases that cause disability and death are due to organ fibrosis. However, there have been so far only a few effective treatments for organ fibrosis. Idiopathic pulmonary fibrosis (IPF) is progressive, lethal fibrotic lung disease. Approximately, 10/100,000 people globally suffer from pulmonary fibrosis, and the incidence is on the rise. The median survival for patients is only 3-5 years. Currently there is no effective treatment for lung fibrosis. Therefore, new insights into lung fibrosis and therapeutic strategy should be explored and developed. This Research Topic aims to deepen the understanding and research on the pathogenesis of lung fibrosis to develop effective treatments. Studies have shown that effective lung repair and regeneration are critical biological processes for the restoration of original physiological function of lung after injury. The intrinsic ability of regeneration and repair is often suppressed in lung with chronic injury or the diseased organs, leading to fibrosis and loss of function. Targeting key pathways in the process of lung regeneration can promote the repair of the impaired lung and alleviate fibrosis in animal models. How to induce regeneration and repair of the impaired organ to alleviate fibrosis is a frontier research topic. Hence, this Research Topic focuses on the cellular and molecular mechanisms of lung regeneration, repair, and fibrosis. Moreover, this topic will also focus on the study of lung development to provide new insights into the pathogenesis of lung injury and fibrosis.
Author :
Publisher :
Page : 0 pages
File Size : 31,24 MB
Release : 1994
Category :
ISBN :
Author : Kamal Dua
Publisher : Springer Nature
Page : 926 pages
File Size : 27,22 MB
Release : 2021-07-02
Category : Medical
ISBN : 9813368276
The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.
Author : Hikaru Koide
Publisher :
Page : 244 pages
File Size : 36,52 MB
Release : 1994
Category : Medical
ISBN :
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
Page : 728 pages
File Size : 18,18 MB
Release : 2010
Category : Government publications
ISBN :
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : Alexis Desmouliere
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 50,83 MB
Release : 2012-12-06
Category : Medical
ISBN : 364258456X
With contributions by numerous experts
Author : Nikolic, Marko Z.
Publisher : European Respiratory Society
Page : 395 pages
File Size : 24,74 MB
Release : 2021-04-01
Category : Medical
ISBN : 1849841349
Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science
Author : Cecilia Battistelli
Publisher : Frontiers Media SA
Page : 219 pages
File Size : 11,2 MB
Release : 2020-02-10
Category :
ISBN : 2889635023
Author :
Publisher :
Page : 776 pages
File Size : 22,77 MB
Release : 1989
Category : Medicine
ISBN :