Cellular and Molecular Mechanisms in Immune Tolerance to Renal Cancer
Author : Xavier Frigola Baró
Publisher :
Page : 107 pages
File Size : 16,15 MB
Release : 2009
Category :
ISBN :
Author : Xavier Frigola Baró
Publisher :
Page : 107 pages
File Size : 16,15 MB
Release : 2009
Category :
ISBN :
Author : Ronald M. Bukowski
Publisher : Springer Science & Business Media
Page : 488 pages
File Size : 19,31 MB
Release : 2000-04-10
Category : Medical
ISBN : 1592592295
Renal cell carcinoma represents a heterogeneous group of tumors, the most common of which is clear cell adenocarcinoma. The annual incidence of this tumor appears to be rising and approximately 12,000 individuals die from this cancer annually in the United States. One third of patients who present have metastatic disease at the time of diagnosis, and another 40% who undergo nephrectomy will ultimately develop this complication. Over the past 10 years, a significant amount of new information concerning the epidemiology, mole- lar and immunologic characteristics, and therapy for patients with these tumors has appeared. The recognition that inherited forms of renal cancer exist, and that chromosomal abn- malities can be identified in these tumors, suggested a genetic basis for renal cell carcinoma. The familial cancer syndrome, Von Hippel Lindau disease, provided the setting in which the genetic abnormalites associated with the development of renal cancer were first described. Abnormalities of the VHL gene have also been detected in sporadic clear cell carcinoma, and it has now been recognized that approximately 80 % of these tumors will demonstrate ch- acteristic alterations. Currently the functions of the VHL protein are being investigated, and the biology of clear cell carcinoma of the kidney is under study. Additionally, papillary carcinomas of the kidney appear to express different molecular defects, and these are now being unraveled.
Author : Laurence Zitvogel
Publisher : Springer
Page : 700 pages
File Size : 35,71 MB
Release : 2017-12-13
Category : Medical
ISBN : 3319624318
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Author : Frans M.J. Debruyne
Publisher : Springer
Page : 0 pages
File Size : 14,76 MB
Release : 1991-01-29
Category : Medical
ISBN : 9783540528357
With contributions by numerous experts
Author :
Publisher :
Page : 742 pages
File Size : 11,92 MB
Release : 1989
Category : Medicine
ISBN :
Author : Bruce Alberts
Publisher :
Page : 0 pages
File Size : 37,48 MB
Release : 2002
Category : Cytology
ISBN : 9780815332183
Author : Robert T. McCluskey
Publisher :
Page : 440 pages
File Size : 34,70 MB
Release : 1974
Category : Cellular immunity
ISBN :
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
Page : 728 pages
File Size : 12,17 MB
Release : 2010
Category : Government publications
ISBN :
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author :
Publisher :
Page : 1064 pages
File Size : 43,58 MB
Release : 1992
Category : Medicine
ISBN :
Author : Jörg Reichrath
Publisher : Springer Science & Business Media
Page : 148 pages
File Size : 44,81 MB
Release : 2007-06-25
Category : Medical
ISBN : 0387350985
This book provides a comprehensive, highly readable overview of our current knowledge of the molecular pathology of basal cell and squamous cell carcinomas. The chapters present the newest findings in epidemiology, photocarcinogenesis, genetics, immunology and molecular pathology of these epithelial skin tumours. The book will interest researchers or clinicians interested in the carcinogenesis and biology of basal cell or squamous cell carcinomas.