Cellular and Molecular Neurophysiology


Book Description

Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. - 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations - Fifteen appendices describing neurobiological techniques are interspersed in the text




Foundations of Cellular Neurophysiology


Book Description

with simulations and illustrations by Richard Gray Problem solving is an indispensable part of learning a quantitative science such as neurophysiology. This text for graduate and advanced undergraduate students in neuroscience, physiology, biophysics, and computational neuroscience provides comprehensive, mathematically sophisticated descriptions of modern principles of cellular neurophysiology. It is the only neurophysiology text that gives detailed derivations of equations, worked examples, and homework problem sets (with complete answers). Developed from notes for the course that the authors have taught since 1983, Foundations of Cellular Neurophysiology covers cellular neurophysiology (also some material at the molecular and systems levels) from its physical and mathematical foundations in a way that is far more rigorous than other commonly used texts in this area.




Molecular and Cellular Physiology of Neurons


Book Description

Molecular and Cellular Physiology of Neurons: Second Edition is a comprehensive, up-to-date introduction to essential concepts of cellular neuroscience. Emphasizing experimental approaches and recent discoveries, it provides an in-depth look at the structure and function of nerve cells, from protein receptors and synapses to the biochemical processes that drive the mammalian nervous system. Starting with the basics of electrical current flow across cell membranes, Gordon Fain covers voltage gating and receptor activation in the context of channel diversity, excitatory and inhibitory synaptic transmission, neuromodulation, and sensory transduction. Emphasizing long-term processes of synaptic potentiation and depression involved in memory, consciousness, and attention, he demonstrates how cells produce neural signals and regulate signal flow to enhance or impede cell-to-cell communication. Fain also addresses the relation of molecular and cellular mechanisms to evolving theories of neurological disease and addiction. Enhanced by more than two hundred illustrations, Molecular and Cellular Physiology of Neurons: Second Edition is intended for anyone who seeks to understand the fundamentals of nerve cell function, including undergraduate and graduate students in neuroscience, students of bioengineering and cognitive science, and practicing neuroscientists who want to deepen their knowledge of recent discoveries in molecular and cellular neurophysiology.




Cellular Physiology and Neurophysiology E-Book


Book Description

Gain a quick and easy understanding of this complex subject with the 2nd edition of Cellular Physiology and Neurophysiology by doctors Mordecai P. Blaustein, Joseph PY Kao, and Donald R. Matteson. The expanded and thoroughly updated content in this Mosby Physiology Monograph Series title bridges the gap between basic biochemistry, molecular and cell biology, neuroscience, and organ and systems physiology, providing the rich, clinically oriented coverage you need to master the latest concepts in neuroscience. See how cells function in health and disease with extensive discussion of cell membranes, action potentials, membrane proteins/transporters, osmosis, and more. Intuitive and user-friendly, this title is a highly effective way to learn cellular physiology and neurophysiology. Focus on the clinical implications of the material with frequent examples from systems physiology, pharmacology, and pathophysiology. Gain a solid grasp of transport processes—which are integral to all physiological processes, yet are neglected in many other cell biology texts. Understand therapeutic interventions and get an updated grasp of the field with information on recently discovered molecular mechanisms. Conveniently explore mathematical derivations with special boxes throughout the text. Test your knowledge of the material with an appendix of multiple-choice review questions, complete with correct answers Understand the latest concepts in neurophysiology with a completely new section on Synaptic Physiology. Learn all of the newest cellular physiology knowledge with sweeping updates throughout. Reference key abbreviations, symbols, and numerical constants at a glance with new appendices.




Cellular and Molecular Physiology of Cell Volume Regulation


Book Description

The ability to regulate cell volume in the face of osmotic challenge is one of the most fundamental of cellular homeostatic mechanisms. Cellular and Molecular Physiology of Cell Volume Regulation is an integrated collection of articles describing key aspects of cell volume control. The book has been organized around concepts and cellular/molecular processes rather than around mechanisms of volume regulation in specific cell types in order to make it more accessible to a multidisciplinary audience of students, instructors, and researchers.




Quantitative Fundamentals of Molecular and Cellular Bioengineering


Book Description

A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.




From Molecules to Networks


Book Description

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. - Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook - Discusses emerging new understanding of non-classical molecules that affect neuronal signaling - Full colour, professional graphics throughout - Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer's disease




Cellular and Molecular Neurophysiology


Book Description

Unveiling the latest research in neurophysiology, Cellular and Molecular Neurophysiology, Fifth Edition continues to stand as the only resource in the field. This book remains the standard for those who seek to explore the intricate molecular and cellular physiology of neurons and synapses. Notably, this new edition delves even deeper into the molecular properties and functions of excitable cells, offering unparalleled insights. In this edition, there are two groundbreaking chapters. The first reviews metabotropic receptors for olfactory transduction, while the second presents cutting-edge techniques for neuroscience research. Hypothesis-driven rather than a dry presentation of facts, the content firmly based on numerous experiments performed by top experts in the field, teaches students how to build and conduct intelligent research experiments. This book promotes a true understanding of nerve cell function and will be a useful resource for practicing neurophysiologists, neurobiologists, neurologists, and students in a graduate-level course on the topic alike. - Authoritative foundational coverage of basic cellular and molecular neurophysiology - Includes new chapters on metabotropic olfactory receptors for sensory transduction and experimental techniques used by neurophysiologists




From Neuron to Brain


Book Description




Conn's Translational Neuroscience


Book Description

Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. - Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance - Features contributions from leading global basic and clinical investigators in the field - Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes - Relates and translates the current science to the understanding of neurological disorders and their treatment