Cerebral Dysgenesis


Book Description

Among physicians responsible for the care of human infants born with a malformed nervous system, there is a compelling need for an accessible synthesis and summary of modern embryological concepts of dysgenesis. This book integrates the morphological, clinical, neurological, genetic, neurophysiological and imaging aspects of cerebral malformation in the context of a lucid embryological explanation. Rather than presenting a catalog of anatomical abnormalities, the text focuses on pathogenesis and clinical aspects. Anatomical appearances are described by imaging in life, while neuropathological features are derived from findings at autopsy. Embryological explanations are identified as documented observation or speculation. Among the topics covered are encephaloceles as a disorder of the primitive streak and node; cerebral hypoplasia as a precocious differentiation of the ependyma before all mitotic generations of the neuroepithelial cells are completed; holosprosencephaly as a disorder of the lamina terminalis; agenesis of the corpus callosum as a failure of programmed glial cell death in the callosal plate in preparation for axonal growth cone passage; subcortical heterotopia as an arrest of late neuroblast migrations due to retraction of radial glial guide fibers from the pial surface of the brain. The literature is exhaustively reviewed and supplemented by the author's own experience. The book is richly illustrated throughout.




Clinical Pediatric Neurology


Book Description

This 6th Edition, offers you a practical assistance in diagnosing and managing the primary neurologic disorders of childhood. Simply look up the presenting symptoms, and you'll be guided step by step through evaluation and management. Thorough coverage for each neurological disease clearly defines age at onset, course of illness, clinical features, and treatment options. Differential diagnosis tables and treatment algorithms expedite clinical decision making.




Neurology and General Medicine


Book Description

Better understand your patients' complete medical profile and provide the best possible care! This one-of-a-kind reference provides a practical look at neurological disease and how it affects, and is affected by, other disease. It helps neurologists manage patients with co-existing medical conditions, and helps internists understand and treat the neurological manifestations of patients' primary diseases. A new emphasis on diagnosis and management-including advances in pharmacology, genetic-based therapies, and new imaging techniques-makes this 4th Edition more clinically valuable than ever! Focused content highlights the vital links between neurology and other medical specialties, promoting a better understanding of all disciplines, as well as enhancing patient care. Comprehensive coverage of advances in pharmacology, such as new antibiotics for infectious diseases, helps you successfully manage a full range of diseases and disorders. An interdisciplinary team of authors provides insight into the neurological aspects of the conditions you see in daily practice. Easy-to-read chapters apply equally well to neurologists and non-neurologists, providing essential knowledge that covers the full spectrum of medical care. Expanded chapters emphasize key diagnostic and therapeutic information, including appropriate testing and treatments for neurological disease. An emphasis on advances in pharmacology and new imaging techniques helps you better manage your patients and understand how new drugs or therapies will affect your patients and practice. New chapters on auditory and vestibular disease, ocular disease, and cutaneous disease provide a well-rounded look at the specialty. Updated illustrations make complex concepts easier to understand and apply.




Fundamentals of Neurologic Disease


Book Description

This textbook is intended for students in neurology and a variety of related disciplines who wish to learn the basic principles of neurology and to understand common neurologic diseases. It is designed to be read from cover to cover in a 3-4 week neurology rotation, or in a classroom situation, giving the reader a thorough understanding of the fundamentals of neurology. encountering a patient with a neurologic problem, the key elements of the neurologic exam, and an overview of common neurologic tests. They discuss how to use the history and neurologic exam to localize the patient's problem to specific neuroanatomic sites and to use the neuroanatomic information along with results of appropriate laboratory tests to establish a diagnosis. diseases presenting at different neuroanatomic sites along the neuroaxis, from muscle to the cerebral cortex, and chapters on diseases that have similarpathophysiologies. The authors selected 58 neurologic diseases based on their frequency, ability to represent that category of neurologic disease, value in teaching neuroscience concepts, and diagnostic importance. Each chapter begins with an overview to understand the common features of this group of diseases. Selected diseases are then discussed with an emphasis on the pathophysiology, major clinical features, major laboratory findings, and the principles of disease management. This book covers both adult and pediatric neurologic diseases as well as selected neurosurgical diseases. a neurology service or in the classroom. * The book focuses on the most important neurologic diseases, carefully selected based on frequency, ability to represent that category of neurologic disease, value in teaching neuroscience concepts, and diagnostic importance. Thus, students with a limited period of time can focus on the most important neurologic diseases that they need to understand. This is in contrast to existing texts that list virtually every disease within each category, with each disease given almost equal weight regardless of its importance, as a result of which the student can easily become confused as to which disease are important to understand. including the basic principles of the test, when the test is helpful, and some general principles toward interpretation of the results. This approach helps students understand in the later chapters why certain tests are recommended for specific diseases. * Each disease chapter begins with an extensive introduction that includes the features of illnesses that occur at that anatomic location or class of disease. This helps a reader understand how to localize neurologic illnesses that in turn leads to improved differential diagnosis and the better ordering of diagnostic tests. It also helps the reader understand how the nervous system is organized and how disease in each part can lead to specific types of signs and symptoms. books that just list signs and symptoms, diagnostic tests ordered, and drugs with doses that can be used. This book allows the student to better understand the etiology, the pathology and how the pathology causes neurologic signs and symptoms. * Two color printing of illustrations greatly improves readability. No other common student book has this.




Progressive Brain Disorders in Childhood


Book Description

A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.




The Epilepsies


Book Description

This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.




Malformations of the Nervous System


Book Description

This volume deals with brain development malformations of the central nervous system, showcasing a unique approach that furthers research through systematic integration of exciting new developments from fields including molecular genetics, neuroimaging, and neuropathology. By integrating data and research from these disciplines, better conceptualization of the mechanisms of the developmental processes is achieved. Clinicians will find invaluable insights into complex issues, including midline hypoplasias, disorders of segmentation of the neural tube, and hamartomatous disorders of cellular lineage, amongst others. The clinical manifestations of central nervous system malformations are also discussed, along with new advancements in MRI techniques and analysis, including volumetric morphology, spectroscopy, and functional neuroimaging. Sections dedicated to management and treatment are also included in an effort to aid clinicians in their goal of providing better care for individuals affected by these types of malformations. * A single source that encompasses the various aspects of cerebral malformations * A unique approach that furthers research through systematic integration of exciting new developments from fields including molecular genetics, neuroimaging, and neuropathology* New diagnostic tools, management protocols, and treatments for patient care




Psychiatric and Behavioural Disorders in Intellectual and Developmental Disabilities


Book Description

Entirely revised and updated, this edition of a very well-received and successful book provides the essentials for all those involved in the fields of intellectual, developmental and learning disabilities and mental retardation, drawing both on clinical experience and the latest research findings. An international, multidisciplinary team of experts cover the available literature in full and bring together the most relevant and useful information on mental health and behavioural problems of people with intellectual, developmental and learning disabilities and mental retardation. In addition, this book highlights the principles behind clinical practice for assessment, management and services. It offers hands-on, practical advice for psychiatrists, psychologists, nurses, therapists, social workers, managers and service providers.




Hypoplastic Left Heart Syndrome


Book Description

Hypoplastic left heart syndrome (HLHS) is one of the last forms of congenital heart disease to yield to effective treatment. Over the past 20 years major advances in diagnostics, surgical intervention, and our understanding of the pathophysiology of HLHS - much of it developed at The Children's Hospital of Philadelphia - has led to marked improvement in overall outcome for children born with this complex form of congenital heart disease. The extensive experience with over 1,000 consecutive cases of HLHS treated at The Children's Hospital of Philadelphia forms the basis of knowledge for this book. Hypoplastic Left Heart Syndrome is a complete compendium of the "state-of-the-art" on the subject of HLHS and related conditions. The spectrum of topics covered include: genetics and prenatal evaluation, diagnostic assessment, pre- and post-operative management, latest developments in surgical strategies, as well as short and intermediate term outcomes. Sections on quality of life issues such as neurological status, feeding, and late complications are also included. Unique chapters on the impact of congenital heart disease on health care economics, concerns of the pediatrician caring for these patients, and a poignant chapter offering thoughts from a patient and families with HLHS round out the book. Hypoplastic Left Heart Syndrome is a single source, complete text for cardiologists, cardiovascular surgeons, nurses, pediatricians, parents and others who care for, or have an interest in, this complex congenital heart anomaly.




Companion to Clinical Neurology


Book Description

"Depicts or explains neurology's bygone leaders as well as its symptoms, signs, syndromes, diseases, eponyms, operative procedures, and diagnostic tests."--Foreword.