Collagen


Book Description

J. Brinckmann: Collagens at a Glance.- J. Engel, H.P. Bächinger: Structure, Stability and Folding of the Collagen Triple Helix.- S. Ricard-Blum, F. Ruggiero, M. van der Rest: The Collagen Superfamily.- T. Koide, K. Nagata: Collagen Biosynthesis.- J. Myllyharju: Intracellular Post-Translational Modifications of Collagens.- D.S. Greenspan: Biosynthetic Processing of Collagen Molecules.- D.E. Birk, P. Bruckner: Collagen Suprastructures.- D.R. Eyre, J.-J. Wu: Collagen Cross-Links




Fibrous Proteins: Coiled-Coils, Collagen and Elastomers


Book Description

Fibrous Protein: Coiled-Coils, Collagen and Elastomers is the first of a three-part series on Fibrous Proteins. The books are based on a very successful workshop in Alpbach, Austria on the general topic of Fibrous Proteins that gave rise to the award winning issue of Journal of Structural Biology. Part II will contain an extensive discussion of Molecular Motors and Muscle, Part III on Amyloids, Prions and Beta Proteins. Advances in Protein Chemistry is available online on ScienceDirect - full-text online of volumes 53 onwards. Reveals new structural and functional aspects of fibrous proteins Based on Fibrous Protein workshop in Alpbach, Austria that gave rise to 2003 Nobel Prize winners in Chemistry




Biophysical and Chemical Properties of Collagen: Biomedical Applications: Biomedical Applications


Book Description

Biophysical and Chemical Properties of Collagen: Biomedical Applications provides an introduction to the biophysics and chemistry of collagen and its use as a biomedical material in the rapidly changing fields of biomedical device production, tissue engineering and regenerative medicine. Written by experts in the field, this text will be of interest for researchers as well as lecturers and students.







Collagen


Book Description

Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.




Biochemistry of Collagen


Book Description

Collagen is a fascinating protein not only because of its ubiquitous occurrence in multicellular animals, but also because of its unique chemi cal structure. As the predominant constituent in bone, cartilage, skin, tendon, and tooth, it is not surprising that collagen is of interest to anatomists, biochemists, biomedical engineers, cell biologists, dermatolo gists, dental surgeons, leather chemists, orthopedic surgeons, physiologists, physicians, zoologists, and a host of others. This book was planned to provide an up-to-date comprehensive survey of all aspects of biochemistry of collagen. The recent discovery of genetically distinct collagens with tissue specificity has opened a new era in collagen biochemistry, and Karl Piez discusses this in the opening chapter on primary structure. In the next chapter, Ramachandran and Rama krishnan deal with the molecular structure of collagen, placing special emphasis on the conformational aspects of its polypeptide chains. Follow ing the consideration of primary and secondary structure of collagen, the three-dimensional arrangement of collagen molecules in the fibrils is covered by Miller in Chapter 3. Collagen is generally in the insoluble state in the living organism due to the cross-linking of individual molecules, and Tanzer describes the various aspects of this cross-linkage in Chapter 4. The biosynthesis of collagen is discussed in depth by Prockop and his colleagues.




Molecular Parameters Indicating Adaptation to Mechanical Stress in Fibrous Connective Tissue


Book Description

The connective and supportive tissues constitute a considerable amount of the biomass in human and animal organisms. The aim of this book is to contribute to the understanding of the mutual relationship between the mechanical situation of tendons and ligaments and their inner structure.




Tanning Chemistry


Book Description

Even in the 21st Century, the manufacture of leather retains an air of the dark arts, still somewhat shrouded in the mysteries of a millennia old, craft based industry. Despite the best efforts of a few scientists over the last century or so, much of the understanding of the principles of tanning is still based on received wisdom and experience. Leather is made from (usually) the hides and skins of animals - large animals such as cattle have hides, small animals such as sheep have skins. The skin of any animal is largely composed of the protein collagen, so it is the chemistry of this fibrous protein and the properties it confers to the skin with which the tanner is most concerned. In addition, other components of the skin impact on processing, impact on the chemistry of the material and impact on the properties of the product, leather. Therefore, it is useful to understand the relationships between skin structure at the molecular and macro levels, the changes imposed by modifying the chemistry of the material and the eventual properties of the leather. This book aims to contribute to changing the thinking in the industry, to continue building a body of scientific understanding, aimed at enhancing the sustainability of an industry which produces a unique group of materials, derived from a natural source. The Science of Leather is the only current text on tanning science, and addresses the scientific principles which underpin the processes involved in making leather. It is concerned with the chemical modification of collagen, prior to tanning and the tanning reactions in particular. The subject is covered in the following order: collagen chemistry, collagen structure, skin structure, processing to prepare for tanning, the tanning processes and processing after tanning. The aim of the book is to provide leather scientists and technologists with an understanding of how the reactions work, the nature of their outcomes and how the processes can be controlled and changed. The objective is to synthesise a scientific view of leather making and to arrive at an understanding of the nature of tanning - how the wide range of chemistries employed in the art can change the properties of collagen, making leather with different properties, especially conferring different degrees of stabilisation as measured by the hydrothermal stability. Environmental issues are not treated as a separate theme - the impact of leather making on the environment is a thread running through the text, with the assumption that better understanding of the science of leather making will lead to improved processing. The book also reflects on the ways leather technology may develop in the future based on the foundation of understanding the scientific principles which can be exploited. It also includes a subject index, references and a glossary. The book provides the reader with insights into the role science plays in leather technology and provides fundamental understanding, which should be the basis for scientific and technological research and development for the benefit of the global leather industry. The book is aimed at students, leather scientists and technologists, in both academia and industry, in leather production and in chemical supply houses.




Ultrastructure of the Connective Tissue Matrix


Book Description

In recent years, the techniques of electron microscopy have developed so widely and rapidly that they now cover the fields of research once the unique ll:panage of sister research techniques such as biochemistry, physiology, immunology, X-ray diffraction, etc. It is now possible to reach molecular and submolecular levels, making this technique indispensable in every type of research. Electron microscopy alone often provides enough information to solve given problems. In the field of the connective tissue matrix, knowledge of the molecular structure of collagen, pro teoglycans and elastin and their interaction has been to a large extent elucidated by electron microscopy. The field over which electron microscopy ranges in the investigation of the connective tissue matrix is so wide that the aim of this volume is to collect the main ultrastructural acquisitions disseminated in various journals and monographs in one book. The intent ofthis volume is to: (a) integrate different and new microscopic methods and review the results of such an integrative approach; (b) present a comprehensive ultrastructural account of selected aspects of the field; (c) point out gaps or controversial topics in our knowledge; (d) outline pertinent future research and expansion of the subject.




Biochemistry of Collagens, Laminins and Elastin


Book Description

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. - Provides a comprehensive introduction to collagen and structural proteins - Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation - Includes a chapter dedicated to the biomarkers of structural proteins - Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states