Author : L. S. Hnilica
Publisher : CRC Press
Page : 264 pages
File Size : 22,20 MB
Release : 2018-12-20
Category : Science
ISBN : 1351079131
The second volume of the Chromosomal Nonhistone Proteins treatise is dedicated in its entirety to the immunobiology of these proteins. Since immunological methods are adding rapidly to our knowledge of the specificity and intranuclear localization of chromosomal nonhistone proteins, a collection of chapters dealing with various aspects of this important area was judged appropriate.
Author : L. S. Hnilica
Publisher : Springer
Page : 288 pages
File Size : 37,96 MB
Release : 1983-02
Category : Science
ISBN :
Author : I. Bekhor Isaac
Publisher : CRC Press
Page : 248 pages
File Size : 14,45 MB
Release : 2018-05-04
Category : Medical
ISBN : 1351092960
The purpose of this text is to encourage research on nonhistones and to stimulate the imagination of other investigators whose future efforts might result in new discoveries as to the significance of these proteins.
Author : John R. Gosden
Publisher : Springer Science & Business Media
Page : 508 pages
File Size : 28,21 MB
Release : 2008-02-02
Category : Medical
ISBN : 1592595162
Chromosomes, as the genetic vehicles, provide the basic material for a large proportion of genetic investigations, from the construction of gene maps and models of chromosome organization, to the inves tigation of gene function and dysfunction. The study of chromosomes has developed in parallel with other aspects of molecular genetics, beginning with the first preparations of chromosomes from animal cells, through the development of banding techniques, which permitted the unequivocal identification of each chromosome in a karyotype, to the present analytical methods of molecular cytogenetics. Although some of these techniques have been in use for many years, and can be learned relatively easily, most published scientific reports—as a result of pressure on space from editors, and the response to that pressure by authors—contain little in the way of technical detail, and thus are rarely adequate for a researcher hoping to find all the necessary information to embark on a method from scratch. A new user needs not only a detailed description of the methods, but also some help with problem solving and sorting out the difficulties en countered in handling any biological system. This was the require ment to which the series Methods in Molecular Biology is addressed, and Chromosome Analysis Protocols forms a part of this series.
Author : Hsueh Jei Li
Publisher : Elsevier
Page : 372 pages
File Size : 37,26 MB
Release : 2012-12-02
Category : Science
ISBN : 0323153631
Chromatin and Chromosome Structure consists of chapters that reflect a 1975 seminar course and the reported observations after the session. The seminar is organized for the benefit of both faculty and students in the Biology Ph.D. Program of the City University of New York. This book begins with a presentation of the conformational studies of histones. It then describes the histone-DNA interactions and the subunits isolated either from chromatin or from nuclei. It also explains the post-synthetic modifications of histone structure. Furthermore, the book talks about the chemistry and function of nuclear nonhistone proteins, low molecular weight nuclear RNA, and polytene chromosome structure. The regulation of gene expression in chick oviduct model system and the main features of lampbrush chromosomes are shown as well. Aside from the students and faculty of the above-mentioned university, this compilation will be invaluable as well to other undergraduate and graduate students; professors; and researchers. It will also be a good reference to those who are specializing in chromatin and chromosome studies.
Author :
Publisher :
Page : 0 pages
File Size : 23,2 MB
Release : 2002
Category : Cells
ISBN : 9780815332183
Author :
Publisher : Academic Press
Page : 515 pages
File Size : 46,20 MB
Release : 1977-08-24
Category : Science
ISBN : 0080859135
Chromatin and Chromosomal Protein Research I
Author :
Publisher :
Page : 1350 pages
File Size : 11,57 MB
Release : 1975
Category : Medicine
ISBN :
Author : J. E. Celis
Publisher : Springer Science & Business Media
Page : 439 pages
File Size : 26,4 MB
Release : 2013-06-29
Category : Medical
ISBN : 1468445413
This volume is based on the proceedings of a NATO-Gulbenkian Foundation sponsored Summer School held in May-June 1982 in Sintra Estoril, Portugal. Given the accelerated growth of knowledge in the field of eukaryotic gene expression, it seemed timely to hold a NATO Advanced Study Institute to discuss current developments in this area of biology and to evaluate the potential of emerging technologies such as gene transfer, recombinant DNA cloning and quantitative high resolution two-dimensional gel electrophoresis. The initial articles in t~is volume describe various differentiation models and address questions such as the relationships between differentiation and cell proliferation, biochemical changes accompanying differen tiation, expression of differentiated gene products and their regulation as well as gene organization of cytoskeletal proteins. The second section describes properties of neoplastic cells, surveys current assays for transformation and offers some new insights into the mechanisms involved in carcinogenesis. The third part is dedicated to viral oncogenesis and to the role of onco genes in cell transformation. Particular emphasis is given to the role of tyrosine kinases in cell transformation. The concluding section deals with various aspects of gene expression in normal and transformed cells with special emphasis given to studies using two dimensional gel electrophoresis, cell hybridization, gene transfer and immunological techniques.
Author : Gary S. Stein
Publisher : CRC Press
Page : 426 pages
File Size : 23,58 MB
Release : 1989-06-30
Category : Science
ISBN : 9780849355158
This comprehensive book is a compilation of Professor Lubomir S. Hnilica's twenty years of research experimentally addressing the chemistry and the biological functions of chromosomal proteins. The histones and other nuclear proteins found associated with DNA in a number of tissues and cell types are featured. Lubomir Hnilica played a major role in establishing the extent to which these basic chromosomal polypeptides are conserved and the manner in which they interact with DNA to modify chromatin structure. In addition, non-histone chromosomal protein research is explained, and his technique of applying several biochemical and immunological approaches to the characterization of this complex and heterogeneous class of chromosomal polypeptides is discussed. Highlighted is the use of chemical crosslinking for studying protein/DNA interactions in intact cells. The proteins as well as the structure, organization, and regulation of the genes are also presented.
