Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
Page : 502 pages
File Size : 44,96 MB
Release : 2006-09-29
Category : Medical
ISBN : 1420005847
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Author : José A. Rivera
Publisher : Elsevier
Page : 185 pages
File Size : 30,51 MB
Release : 2013-10-22
Category : Science
ISBN : 1483156575
Cilia, Ciliated Epithelium, and Ciliary Activity reviews the state of knowledge of the activity of cilia and of the role these structures play in maintaining the normal physiology of the body, especially in the respiratory and genital systems. It relates the diversity of manifestations shown by cilia and ciliated epithelium in health and disease, and the effect of the physicochemical agents studied which influence the life and death of these structures. The volume is organized into five sections. Section A provides a general discussion on the history of studies on the ciliated epithelium; the distribution and morphology of cilia; development, regeneration and transformation of ciliated cells; and culture of cilia and ciliated epithelium. Section B deals with ciliary activity while Section C examines the effects of physical and chemical agents on cilia. Section D takes up the function of cilia. Section E contains a list of references of the literature on these topics from the historical beginning of studies in the field to the time of writing. This volume is intended to be a ready-made reference source for workers in the fields of biological sciences and medicine.
Author :
Publisher : Academic Press
Page : 423 pages
File Size : 32,33 MB
Release : 2009-11-30
Category : Science
ISBN : 0080962823
In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. - Covers protocols for primary cilia across several systems and species - Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time - Relevant to clinicians and scientists working in a wide range of fields
Author : Jong Hoon Park
Publisher : Springer
Page : 128 pages
File Size : 37,20 MB
Release : 2016-10-12
Category : Medical
ISBN : 9811020418
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Author : Matthias Salathe
Publisher : CRC Press
Page : 451 pages
File Size : 47,97 MB
Release : 2001-07-27
Category : Medical
ISBN : 1482270587
This book details advances in research regarding cilia, mucus, and mucociliary clearance, examining changes in mucus expression and goblet cell metaplasia, and assessing the ability of the mucociliary system to respond to abnormalities. Recognizes that cilia and dynein arms play pivotal roles in developing mammalian embryos! Examines the rol
Author :
Publisher : Academic Press
Page : 643 pages
File Size : 28,52 MB
Release : 1995-08-31
Category : Science
ISBN : 0080859453
Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella.Key Features* A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher* Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals* Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR* Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures
Author :
Publisher : Academic Press
Page : 434 pages
File Size : 44,49 MB
Release : 2016-06-06
Category : Science
ISBN : 0124172016
Genes and Evolution, the latest volume in the Current Topics in Developmental Biology series, covers genes and evolution, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as genes and plant domestication, gene networks, phenotypic loss in vertebrates, reproducible evolutionary changes, and epithelial tissue. - Covers the area of genes and evolution - Contains invaluable contributions from an international board of authors - Provides a comprehensive set of reviews covering such topics as genes and plant domestication, gene networks, phenotypic loss in vertebrates, reproducible evolutionary changes and epithelial tissue
Author : Kian Fan Chung
Publisher : European Respiratory Society
Page : 365 pages
File Size : 50,42 MB
Release : 2019-06-01
Category : Medical
ISBN : 1849841047
Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
Author : D.F. Rogers
Publisher : Springer Science & Business Media
Page : 408 pages
File Size : 29,75 MB
Release : 1997-09-23
Category : Medical
ISBN : 9783764356910
Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas.
Author : Sir James Gray
Publisher :
Page : 186 pages
File Size : 35,14 MB
Release : 1928
Category : Cilia and ciliary motion
ISBN :
