Improving Food Safety Through a One Health Approach


Book Description

Globalization of the food supply has created conditions favorable for the emergence, reemergence, and spread of food-borne pathogens-compounding the challenge of anticipating, detecting, and effectively responding to food-borne threats to health. In the United States, food-borne agents affect 1 out of 6 individuals and cause approximately 48 million illnesses, 128,000 hospitalizations, and 3,000 deaths each year. This figure likely represents just the tip of the iceberg, because it fails to account for the broad array of food-borne illnesses or for their wide-ranging repercussions for consumers, government, and the food industry-both domestically and internationally. A One Health approach to food safety may hold the promise of harnessing and integrating the expertise and resources from across the spectrum of multiple health domains including the human and veterinary medical and plant pathology communities with those of the wildlife and aquatic health and ecology communities. The IOM's Forum on Microbial Threats hosted a public workshop on December 13 and 14, 2011 that examined issues critical to the protection of the nation's food supply. The workshop explored existing knowledge and unanswered questions on the nature and extent of food-borne threats to health. Participants discussed the globalization of the U.S. food supply and the burden of illness associated with foodborne threats to health; considered the spectrum of food-borne threats as well as illustrative case studies; reviewed existing research, policies, and practices to prevent and mitigate foodborne threats; and, identified opportunities to reduce future threats to the nation's food supply through the use of a "One Health" approach to food safety. Improving Food Safety Through a One Health Approach: Workshop Summary covers the events of the workshop and explains the recommendations for future related workshops.




Contemporary Approaches to Mitigating Antibacterial Drug Resistance


Book Description

In infectious disease management, antibacterial agents have long been viewed as pivotal tools in the relentless battle against microorganisms. However, the escalating threat of antibacterial drug resistance has emerged as a formidable challenge to global health. Contemporary Approaches to Mitigating Antibacterial Drug Resistance delves into the heart of this critical issue, exploring the mechanisms, consequences, and innovative strategies to counteract the surge of resistance, a phenomenon becoming increasingly pervasive and threatening worldwide. Antibacterial drug resistance, a pressing public health concern, transcends geographical boundaries. In regions where antibiotic accessibility and overuse prevail, resistance rates soar, giving rise to the ominous "superbugs." This book unravels the intricacies of drug resistance, examining its impact on infectious disease management, healthcare economics, and societal well-being. The exploration begins with a foundational understanding of antibacterial drug resistance, navigating through the intricate mechanisms that drive its rapid proliferation. Environmental and genetic factors, often overlooked, are dissected for their roles in fostering resistance. The book explores the interplay of antibacterial drugs with micro-biodiversity, shedding light on the indirect repercussions on human and environmental ecosystems. The primary audience, encompassing undergraduate and postgraduate students, medical practitioners, academicians, and researchers, will find in-depth insights into emerging therapeutic targets and recent advances in drug development. The secondary audience, including authorities in antibacterial drug resistance and institutional libraries, will discover a valuable resource addressing the multifaceted dimensions of this global menace.




Management of Antimicrobials in Infectious Diseases


Book Description

Recent evidence suggests an increasing rate of antimicrobial resistant pathogens throughout the world. Pathogens like Staphylococcus aureus are showing substantial prevalence of resistance to antibiotics. Thus, we think that given these developments, clinicians would welcome an updated version of this book. A resource indicating appropriate, evidence-based antimicrobial treatment of infectious diseases encountered in both the hospital and outpatient settings would be of significant value to practicing clinicians. The book would focus on the clinical importance of appropriate diagnosis and treatment of infectious diseases particularly in terms of antibiotic-resistance. The resource would be valuable to countless numbers of junior-level practitioners (residents, nurse practitioners, physician-assistants). Moreover, the book could be a resource for generalists as well as infectious disease specialists.




Antibiotic Resistant Bacteria: A Challenge to Modern Medicine


Book Description

This book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species. The ability of different species of bacteria to resist the antimicrobial agent has become a global problem. As such, the book provides a comprehensive overview of the advances in our understanding of the origin and mechanism of resistance, discusses the modern concept of the biochemical and genetic basis of antibacterial resistance and highlights the clinical and economic implications of the increased prevalence of antimicrobial resistant pathogens and their ecotoxic effects. It also reviews various strategies to curtail the emergence and examines a number of innovative therapeutic approaches, such as CRISPR, phage therapy, nanoparticles and natural antimicrobials, to combat the spread of resistance.




Management of Antimicrobials in Infectious Diseases


Book Description

Arch Mainous III, PhD, Claire Pomeroy, MD, and a panel of experienced physicians offer an eminently practical summary of the most effective evidence-based antimicrobial treatments encountered in both hospital and outpatient settings. Focusing on the clinical impact of appropriate diagnosis and treatment, the book emphasizes those newer aspects of infectious disease management necessitated by the growing problem of antibiotic resistance. It also discusses the major pathogens involved so that practicing clinicians will not only diagnose, but also better treat the infections and complications they cause. Multidisciplinary and highly practical, Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance offers busy clinicians and nurse practitioners a comprehensive and informed guide to navigating the difficult treatment decisions created by the rising tide of antibiotic resistance today.




Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine


Book Description

The National Strategy for Combating Antibiotic Resistant Bacteria, published in 2014, sets out a plan for government work to mitigate the emergence and spread of resistant bacteria. Direction on the implementation of this strategy is provided in five-year national action plans, the first covering 2015 to 2020, and the second covering 2020 to 2025. Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine evaluates progress made against the national strategy. This report discusses ways to improve detection of resistant infections and estimate the risk to human health from environmental sources of resistance. In addition, the report considers the effect of agricultural practices on human and animal health and animal welfare and ways these practices could be improved, and advises on key drugs and diseases for which animal-specific test breakpoints are needed.




Contemporary Diagnosis and Management of Antimicrobial-resistant Bacteria


Book Description

The use and overuse of antimicrobials over the past decades has led to the development of antibiotic-resistant pathogens. Now in its second edition, this handbook features chapters dedicated to the discussion of specific pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), and their clinical presentation and treatment. General precautions to prevent the development of drug-resistant infections are also discussed.