Closed-Loop Control of Blood Glucose


Book Description

This book presents closed-loop blood glucose control in a simple manner, which includes the hardware and "software" components that make up the control system. It provides examples on how mathematical models are formulated as well as the control algorithms that stem from mathematical exercises. The book also describes the basic physiology of blood glucose regulation during fasting and meal from a functional level.







Theory and Applications of Non-integer Order Systems


Book Description

This book collects papers from the 8th Conference on Non-Integer Order Calculus and Its Applications that have been held on September 20-21, 2016 in Zakopane, Poland. The preceding two conferences were held in Szczecin, Poland in 2015, and in Opole, Poland, in 2014. This conference provides a platform for academic exchange on the theory and application of fractional calculus between domestic and international universities, research institutes, corporate experts and scholars. The Proceedings of the 8th Conference on Non-Integer Order Calculus and Its Applications 2016 brings together rigorously reviewed contributions from leading international experts. The included papers cover novel various important aspects of mathematical foundations of fractional calculus, modeling and control of fractional systems as well as controllability, detectability, observability and stability problems for this systems.




MACHINE LEARNING APPLICATIONS IN HEALTHCARE


Book Description

The study of healthcare data collection, transmission, processing, storage, and retrieval is called healthcare informatics. This area of study is crucial for preventing sickness, detecting diseases early, diagnosing them early, and treating them early. In the field of healthcare informatics, the sole data that is deemed trustworthy pertains to diseases, patient records, and the computational processes needed to decipher this data. In the past 20 years, traditional medical practices in the US have poured a lot of money on cutting-edge computing and technology infrastructure to help them better serve patients, doctors, and academics. Much effort has gone into improving the quality of medical care that can be delivered using these methods. The driving force behind all of these endeavors was a desire to provide patients with healthcare that was not only affordable and of high quality, but also entirely anxiety-free. Thanks to these initiatives, the value of computational tools for facilitating prescriptions and referrals, establishing and maintaining EHR, and advancing digital medical imaging technology has been increasingly apparent. The installation and administration of electronic health records (EHR) can also be facilitated by these instruments. Clinical trials have demonstrated that computerized physician order entry (CPOE) has the potential to enhance patient care while decreasing medication errors and side effects. By utilizing CPOE, doctors may quickly access relevant patient data without leaving the screen where they are inputting prescriptions. The patient's medical history alerts the treating physician to any potential adverse reactions in advance. Another perk of CPOE is that it lets doctors track their orders as they progress through the system. This provides an additional tool for doctors to assess prescription issues and revise them to remove human error as a potential cause. A logical outgrowth of AI research, machine learning emerged with the field's maturation. Researchers and doctors often turn to machine learning when faced with challenging statistical computations. When people talk about healthcare informatics, they usually imply the study of how to use machine learning in conjunction with healthcare data to find important trends in healthcare. That is why healthcare informatics is all on finding patterns in data so you can learn more. The broad usage of electronic health records (EHRs) has helped bring down the cost of medical treatment by making it easier for hospitals to access and exchange their patients' medical information. Cuts to overhead and elimination of superfluous health exams likely contributed to this price drop. Nevertheless, with the current state of EHR administration, it is difficult to collect and analyze clinical data for trends and patterns across distinct populations. This is because there is now a great deal of uncertainty around the administration of EHR systems. The American Recovery and Reinvestment Act (ARRA) of 20091 and similar programs have made great strides in the direction of standardizing the digitalization of medical records. This makes the possibility of building massive medical databases a real possibility. When data is retrieved from these massive archives, machine learning may be employed to create forecasts and comprehend patterns in other domains. Finding strategies to avoid the computational difficulties that are preventing the distribution, sharing, and standardization of electronic health records (EHRs) is the fundamental objective of research that is being conducted in this area. Because these databases contain sensitive information on patients, the objective is to create openaccess databases that are not just secure but also resistant to a wide variety of cyberthreats. This is because the databases contain sensitive information about individual patients. The regional medical databases that are given below are some samples of some of the most well-known databases in the country: Before these vast data repositories of medical information can be developed, there are a number of obstacles that need to be overcome, as will be illustrated in the following sections; substantial expenditures in research and computer resources are required in order to handle these challenges. In order to resolve these challenges, it is necessary to have a significant amount of money. For instance, in order to integrate newly developed technologies for medical devices and the data that they generate, it will be necessary to manage data structures that are always evolving in order to accommodate these new technologies. It is inevitable that this will occur due to the fact that it will be essential to adapt to the new technology.




Control Applications for Biomedical Engineering Systems


Book Description

Control Applications for Biomedical Engineering Systems presents different control engineering and modeling applications in the biomedical field. It is intended for senior undergraduate or graduate students in both control engineering and biomedical engineering programs. For control engineering students, it presents the application of various techniques already learned in theoretical lectures in the biomedical arena. For biomedical engineering students, it presents solutions to various problems in the field using methods commonly used by control engineers. - Points out theoretical and practical issues to biomedical control systems - Brings together solutions developed under different settings with specific attention to the validation of these tools in biomedical settings using real-life datasets and experiments - Presents significant case studies on devices and applications




Microelectronic Design of Fuzzy Logic-Based Systems


Book Description

Fuzzy logic has virtually exploded over the landscape of emerging technologies, becoming an integral part of myriad applications and a standard tool for engineers. Until recently, most of the attention and applications have centered on fuzzy systems implemented in software. But these systems are limited. Problems that require real-time operation, low area, or low power consumption demand hardware designed to the fuzzy paradigm - and engineers with the background and skills to design it. Microelectronic Design of Fuzzy Logic-Based Systems offers low-cost answers to issues that software cannot resolve. From the theoretical, architectural, and technological foundation to design tools and applications, it serves as your guide to effective hardware realizations of fuzzy logic. Review fuzzy logic theory and the basic issues of fuzzy sets, operators, and inference mechanisms Explore the trade-offs between efficient theoretical behavior and practical hardware realizations Discover the properties of the possible microelectronic realizations of fuzzy systems - conventional processors, fuzzy coprocessors, and fuzzy chips Investigate the design of fuzzy chips that implement the whole fuzzy inference method into silicon Analyze analog, digital, and mixed-signal techniques Reduce your design effort for fuzzy systems with CAD tools - learn the requirements they should meet and survey current environments. Put it all together - see examples and case studies illustrating how all of this is used to solve particular problems related to control and neuro-fuzzy applications




Fuzzy Logic And Soft Computing


Book Description

Soft computing is a new, emerging discipline rooted in a group of technologies that aim to exploit the tolerance for imprecision and uncertainty in achieving solutions to complex problems. The principal components of soft computing are fuzzy logic, neurocomputing, genetic algorithms and probabilistic reasoning.This volume is a collection of up-to-date articles giving a snapshot of the current state of the field. It covers the whole expanse, from theoretical foundations to applications. The contributors are among the world leaders in the field.




Control Theory in Biomedical Engineering


Book Description

Control Theory in Biomedical Engineering: Applications in Physiology and Medical Robotics highlights the importance of control theory and feedback control in our lives and explains how this theory is central to future medical developments. Control theory is fundamental for understanding feedback paths in physiological systems (endocrine system, immune system, neurological system) and a concept for building artificial organs. The book is suitable for graduate students and researchers in the control engineering and biomedical engineering fields, and medical students and practitioners seeking to enhance their understanding of physiological processes, medical robotics (legs, hands, knees), and controlling artificial devices (pacemakers, insulin injection devices).Control theory profoundly impacts the everyday lives of a large part of the human population including the disabled and the elderly who use assistive and rehabilitation robots for improving the quality of their lives and increasing their independence. - Gives an overview of state-of-the-art control theory in physiology, emphasizing the importance of this theory in the medical field through concrete examples, e.g., endocrine, immune, and neurological systems - Takes a comprehensive look at advances in medical robotics and rehabilitation devices and presents case studies focusing on their feedback control - Presents the significance of control theory in the pervasiveness of medical robots in surgery, exploration, diagnosis, therapy, and rehabilitation




Recent Advances in Operations Management Applications


Book Description

This book presents the select proceedings of the International Conference on Industrial and Manufacturing Systems (CIMS 2020). It presents the current scenarios and future advancements in the domain of industrial engineering under context of optimum value. Various topics covered include optimisation and its applicability in the various areas of industrial engineering like selection of designing parameters and, decisions related to conditions of optimum process/operation parameters, facilities planning and management, transportation and supply chain management, quality engineering, reliability and maintenance, system optimization, product design and development, human factors and ergonomics, project management, service system and service management, waste management, sustainable manufacturing and operations, systems design, lean manufacturing, and performance measurement. This book will be useful for the students, researchers and professionals working in the area of industrial and production engineering.




Quantitative Systems Pharmacology


Book Description

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource. - Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology - Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy - Discusses how drugs are driven to specific targets using nanoparticles - Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance - Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation