Janeway's Immunobiology


Book Description

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.




Current Immunosuppressive Therapy in Organ Transplantation


Book Description

Organ transplantation has revolutionized the treatment for end-stage organ failure. Immunosuppression is still a major approach currently used in the prevention and treatment of allograft rejection. Both editors Dr. Chen and Dr. Qian have been contributing to preclinical evaluation of immunosuppressants for more than 25 years in North America. Experts from the United States, Canada, the United Kingdom, China, Japan, Germany, Sweden, Hungary and Brazil contributed 23 chapters to this book, providing details of immunological basis in transplantation. They also describe six classes of immunosuppressive agents (calcineurin inhibitors, mTOR inhibitors, JAK-STAT inhibitors, antiproliferative agents, costimulation blockers and corticosteroids), as well as ischemia/reperfusion injury treated agents. Additionally, the new development of cell therapy in the induction of transplant tolerance is introduced. This book provides many important references for the research direction of novel immunosuppressants. Readers that will find this book useful include transplant physicians, surgeons, nurses, immunologists, pharmacologists, pharmacists, medical students, residents and trainees in transplantation.




Immune Rebalancing


Book Description

Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. - Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes - Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections - Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches - Provides information on the new strategies for drug development in this field - Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader's strategy for addressing therapeutic immune modulations




Recent Advances and Clinical Outcomes of Kidney Transplantation


Book Description

Advances in immunosuppression and kidney transplant techniques have led to significant improvements in the short-term survival of the renal allograft. Long-term graft survival, however, has relatively lagged behind and has now become one of the main problems in kidney transplantation. In this Special Issue, we discuss the recent research developments in kidney transplants that may affect long-term allografts, as well as the survival of the patient. The latest developments in living kidney donation are also explored.




Therapeutic Immunosuppression


Book Description

This work has broad applications in clinical medicine, ranging from prevention and treatment of organ and bone marrow transplant rejection, management of various autoimmune disorders (for example, rheumatoid arthritis), skin disease and asthma. Whereas traditionally only a small repertoire of immunosuppressive agents was available for clinical use, recent discoveries have significantly increased the number of approved agents, resulting in numerous trials to further evaluate their potential. There is also considerable interest in the potential of cell-based therapies (particularly hematopoietic stem and dendritic cell therapy) of allo- and autoimmunity. Important recent advances in the immunotherapy of allergic diseases are also covered in this book. This volume is intended both for practising physicians and surgeons and for biomedical scientists at the graduate/postdoctoral levels, and is designed to provide the theory behind these various approaches to immunosuppression, and to provide state-of-the-art reviews of current developments in each area.




Pediatric Solid Organ Transplantation


Book Description

Pediatric Solid Organ Transplantation is acomprehensive and succinct text on all aspects of pediatric solidorgan transplantation. It provides a ready source of reference, toboth the basic science and organ specific surgical technique andafter care. This second edition has been extensively updated inlight of recent developments in this rapidly advancing area. The only textbook devoted to the field of pediatrictransplantation A definitive reference for all those interested in improvingthe care and quality of life of children undergoing solid organtransplantation Section on immunosuppression has been expanded by four chaptersto include sections on; - mechanisms of action - therapies for the sensitized patient - post-transplant lymphoproliferative disorders - organ toxicities of immunosuppressive therapy A new section has been added on the many topics related toquality of life that effect survivors of pediatrictransplantation International editorial and contributor team represents a widegeographical range and contains both recognized leaders andemerging experts Whether you are an established sub-specialist in pediatrictransplantation, a transplant surgeon, or a pediatric specialist ina related area, this book will answer all your questions about careof the pediatric patient before, during, and aftertransplantation.




Uterus Transplantation


Book Description

This book discusses all aspects of the uterus transplantation procedure in women who are childless because of a dysfunctional or missing uterus, from initial pre-operative investigations to follow-up after the uterine graft has been removed. All the international experts who are engaged in clinical activities and/or research in this field have contributed one or more of the book’s chapters. Since the first live birth following uterus transplantation was reported in Sweden in September 2014, the field has been rapidly evolving around the globe: the first cases in USA, Germany, China, Brazil, and Czech Republic were performed in 2016 and several other centres are preparing for clinical trials of uterus transplantation. Uterus transplantation is a subject that attracts the attention of many bioethicists, and like all other major procedures in transplantation surgery and assisted reproduction techniques, it is a complex process that requires a multidisciplinary team if it is to be successful. As such the book is a valuable resource not only for clinicians from many disciplines, but also for nurses, ethicists, psychologists and researchers.




Current Issues and Future Direction in Kidney Transplantation


Book Description

The here presented book covers different areas of clinical and scientific interest, reaching from donor evaluation to newest methods in immunological diagnostics. But also aspects of daily care of transplant recipients can be found in the carefully selected chapters. Everything driven by the aim to improve the care for all of our transplanted patients.




Dermatology and Solid Organ Transplantation


Book Description

This textbook brings together experts in the field of transplant dermatology to review both state of the art and practical knowledge regarding the clinical presentation and management of the various cutaneous diseases seen in patients with solid organ transplant. Practicing dermatologists, trainees, and other health care providers involved in the care of transplant patients can learn the current diagnostic and management options, and how to apply these guidelines and principles in their everyday practice.




Living Donor Advocacy


Book Description

The inadequate supply of organs in the United States and other countries continues to drive the reliance on living donor transplantation. In 2000, representatives of the transplant community convened for a meeting on living donation in an effort to provide guidelines to promote the welfare of living donors. The consensus statement that resulted from this meeting recommended that transplant centers retain an Independent Living Donor Advocate (ILDA) to focus on the best interest of the donor. A decade later, nearly every transplant center in the United States, performing living donor surgeries, has incorporated an ILDA into their living donor screening and/or evaluation process Living Donor Advocate provides an overview of living donation and its risks, ethical challenges and future developments​, as well as details about the role a Living Donor Advocate plays in the transplantation process. This book will interest health professionals across various disciplines and patients undergoing transplantation or living donor surgery.