Current Studies in HIV Research


Book Description

Current Studies in HIV Research brings key topics in HIV/AIDS research to the fore by compiling reviews prepared by HIV/AIDS experts. Readers will benefit from the extensive range of topics covered in this book. Each of the 24 chapters of this volume present a brief account of major facets of HIV/AIDS research including epidemiology, HIV prevention, basic virology, clinical studies (including co-infection with mycobacteria and hepatitis viruses), antiretroviral therapy, treatment options for specific patient groups (such as pregnant women and elderly patients), patient psychology and public health concerns. The book also presents information about issues encountered in practical situations such as management models for non-governmental organizations (NGOs), community involvement in HIV programs and sampling methods in HIV research. Current Studies in HIV Research is, therefore, a useful guide to research information for novice epidemiologists, clinicians, psychologists, sociologists and managers involved in planning and implementing HIV/AIDS research, prevention and monitoring projects.




Current Studies in HIV Research


Book Description

This volume brings key topics in HIV/AIDS research to the fore by compiling reviews prepared by HIV/AIDS experts. Readers will benefit from the extensive range of topics covered in this book. Each of the 24 chapters of this volume present a brief account of major facets of HIV/AIDS research including epidemiology, HIV prevention, basic virology, clinical studies (including co-infection with mycobacteria and hepatitis viruses), antiretroviral therapy, treatment options for specific patient groups (such as pregnant women and elderly patients), patient psychology and public health concerns.




The Social Impact of AIDS in the United States


Book Description

Europe's "Black Death" contributed to the rise of nation states, mercantile economies, and even the Reformation. Will the AIDS epidemic have similar dramatic effects on the social and political landscape of the twenty-first century? This readable volume looks at the impact of AIDS since its emergence and suggests its effects in the next decade, when a million or more Americans will likely die of the disease. The Social Impact of AIDS in the United States addresses some of the most sensitive and controversial issues in the public debate over AIDS. This landmark book explores how AIDS has affected fundamental policies and practices in our major institutions, examining: How America's major religious organizations have dealt with sometimes conflicting values: the imperative of care for the sick versus traditional views of homosexuality and drug use. Hotly debated public health measures, such as HIV antibody testing and screening, tracing of sexual contacts, and quarantine. The potential risk of HIV infection to and from health care workers. How AIDS activists have brought about major change in the way new drugs are brought to the marketplace. The impact of AIDS on community-based organizations, from volunteers caring for individuals to the highly political ACT-UP organization. Coping with HIV infection in prisons. Two case studies shed light on HIV and the family relationship. One reports on some efforts to gain legal recognition for nonmarital relationships, and the other examines foster care programs for newborns with the HIV virus. A case study of New York City details how selected institutions interact to give what may be a picture of AIDS in the future. This clear and comprehensive presentation will be of interest to anyone concerned about AIDS and its impact on the country: health professionals, sociologists, psychologists, advocates for at-risk populations, and interested individuals.




Quantitative Methods for HIV/AIDS Research


Book Description

Quantitative Methods in HIV/AIDS Research provides a comprehensive discussion of modern statistical approaches for the analysis of HIV/AIDS data. The first section focuses on statistical issues in clinical trials and epidemiology that are unique to or particularly challenging in HIV/AIDS research; the second section focuses on the analysis of laboratory data used for immune monitoring, biomarker discovery and vaccine development; the final section focuses on statistical issues in the mathematical modeling of HIV/AIDS pathogenesis, treatment and epidemiology. This book brings together a broad perspective of new quantitative methods in HIV/AIDS research, contributed by statisticians and mathematicians immersed in HIV research, many of whom are current or previous leaders of CFAR quantitative cores. It is the editors’ hope that the work will inspire more statisticians, mathematicians and computer scientists to collaborate and contribute to the interdisciplinary challenges of understanding and addressing the AIDS pandemic.




HIV and Disability


Book Description

The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus qualify for disability benefits. In this report, the Institute of Medicine (IOM) makes several recommendations for improving SSA's capacity for determining disability benefits more accurately and quickly using the HIV Infection Listings.




HIV-1 Latency


Book Description

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.




Disease Control Priorities, Third Edition (Volume 6)


Book Description

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.




Recent Advances in HIV Infection Research


Book Description

The acquired immunodeficiency syndrome (AIDS) is caused by two retroviruses of the lentivirus subfamily, human immunodeficiency viruses types 1 (HIV-1) and 2 (HIV-2), which derive from cross-species transmissions of viruses naturally infecting two African primate species, the chimpanzee (Pan troglodytes) and the sooty mangabey (Cercocebus atys), respectively. Eleven transmission events of lentiviruses from these primate species to humans have been inferred from phylogenetic sequence analyses, although only four (which originated HIV-1 groups M and O, and HIV-2 groups A and B) have resulted in epidemic spread. One of these transmissions, corresponding to the common ancestor of the HIV-1 group M viruses, whose initial expansion in Central Africa has been dated by molecular clock analyses to around 1930, eventually originated the AIDS pandemic. How humans acquired the ancestors of the AIDS viruses from simians is uncertain, but natural infection of African non-human primates with lentiviruses is common, and contact with blood of these animals, which are frequently hunted in Africa for human consumption, is a plausible mechanism for virus acquisition. Sociodemograhic developments, including rapid urbanisation, large scale migrations, growth of prostitution, wars, and increase in travel, and, possibly, the widespread use of non-sterile injection material, may have promoted the emergence of the AIDS pandemic in Central Africa in the 20th century. Subsequent global propagation of HIV-1 derives from multiple introductions at different time points, often representing phylogenetically identifiable founder events. In areas in which diverse HIV-1 variants are cocirculating, these frequently recombine to generate mosaic forms, some of provided new insights on the origin and spread of AIDS viruses and may contribute to the efforts aimed at containing the pandemic which have propagated extensively. Phylogenetic sequence analyses and molecular epidemiology studies have.




Community Collaborative Partnerships


Book Description

Find out how best to develop HIV prevention programs that work Community Collaborative Partnerships: The Foundation for HIV Prevention Research Efforts is a must read for anyone interested in developing prevention programs within high-risk urban environments. Illustrative case studies, quality research, revealing personal stories, and helpful tables and figures provide valuable insights on innovative ways to partner in the prevention of the spread of HIV in youths. Leading experts in the field offer practical strategies to dissolve the distrust individuals in a community hold for researchers not a part of that community, fostering an effective collaboration to deal with problems. The book also describes ways to go beyond the United States’ model to reveal how to replicate the same dynamic relationships in international communities. Active participation with the community and families has been found to be vital for the success of HIV/AIDS prevention efforts. Community Collaborative Partnerships: The Foundation for HIV Prevention Research Efforts solves the common problem of forcing ineffective program models onto an unreceptive community. Program developers get the necessary tools to develop relationships and cultivate substantive input from those in the community to help ensure better program results. The research here is up-to-date, and the suggestions invaluable. Topics in Community Collaborative Partnerships: The Foundation for HIV Prevention Research Efforts include: the role of parenting in mental health and HIV risk research findings about frequency of sexual intercourse among adolescents racial socialization and family role in HIV knowledge family influences on exposure to situations of sexual possibility preadolescent risk behavior influence on parental monitoring strategies for collaboration between community and academic HIV prevention researchers involving urban parents as collaborators in HIV prevention research motivatorsand barriersto participation of minority families in a prevention program transferring a university-led HIV prevention program to the community Trinidad and Tobago HIV/AIDS prevention using a family-based program and much more! Community Collaborative Partnerships: The Foundation for HIV Prevention Research Efforts is valuable reading for researchers, program developers, community-based organizations, public policy/advocacy organizations, community organizers, educators, and students in the fields of social work, public health, public administration, and community medicine.




Big Data Analytics in HIV/AIDS Research


Book Description

With the advent of new technologies in big data science, the study of medical problems has made significant progress. Connecting medical studies and computational methods is crucial for the advancement of the medical industry. Big Data Analytics in HIV/AIDS Research provides emerging research on the development and implementation of computational techniques in big data analysis for biological and medical practices. While highlighting topics such as deep learning, management software, and molecular modeling, this publication explores the various applications of data analysis in clinical decision making. This book is a vital resource for medical practitioners, nurses, scientists, researchers, and students seeking current research on the connections between data analytics in the field of medicine.