Design, Synthesis, and Evaluation of Small Molecules to Identify and Modulate Cellular Processes
Author : Reshma Vidyadharan
Publisher :
Page : pages
File Size : 21,64 MB
Release : 2017
Category :
ISBN :
Author : Reshma Vidyadharan
Publisher :
Page : pages
File Size : 21,64 MB
Release : 2017
Category :
ISBN :
Author : Apryle Marie O'Farrell
Publisher :
Page : 122 pages
File Size : 43,10 MB
Release : 2011
Category :
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Author : Hesham Raffat Shawky Haffez
Publisher :
Page : pages
File Size : 41,40 MB
Release : 2016
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Author : Qiao-Hong Chen
Publisher : MDPI
Page : 606 pages
File Size : 37,64 MB
Release : 2021-03-02
Category : Business & Economics
ISBN : 3036501401
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Author : Mahesh Uttamchandani
Publisher : Methods in Molecular Biology
Page : 274 pages
File Size : 12,2 MB
Release : 2018-12-05
Category : Science
ISBN : 9781493982424
Author : Stefan Bräse
Publisher : Royal Society of Chemistry
Page : 486 pages
File Size : 34,26 MB
Release : 2015-11-20
Category : Medical
ISBN : 1782620303
This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.
Author : Pandi Veerapandian
Publisher : Routledge
Page : 665 pages
File Size : 44,19 MB
Release : 2018-03-29
Category : Medical
ISBN : 1351413066
Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!
Author : Grant David Geske
Publisher :
Page : 432 pages
File Size : 32,75 MB
Release : 2008
Category :
ISBN :
Author : Jeremy L. Baryza
Publisher :
Page : 574 pages
File Size : 42,86 MB
Release : 2005
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Author : Dagmar Klostermeier
Publisher : Walter de Gruyter
Page : 432 pages
File Size : 30,29 MB
Release : 2013-10-14
Category : Science
ISBN : 3110284952
While structure-function relationships of proteins have been studied for a long time, structural studies of RNA face additional challenges. Nevertheless, with the continuous discovery of novel RNA molecules with key cellular functions and of novel pathways and interaction networks, the need for structural information of RNA is still increasing. This volume provides an introduction into techniques to assess structure and folding of RNA. Each chapter explains the theoretical background of one technique, and illustrates possibilities and limitations in selected application examples.