Fetal Cells and Fetal DNA in Maternal Blood


Book Description

Is noninvasive, risk-free prenatal diagnosis of fetal genetic characteristics still a fantasy, or will it soon become reality? The current status of both the leading European research groups as well as the NIH-funded NIFTY study are reported here, indicating that certain fetal genetic traits can now be examined efficiently in a noninvasive manner. Considerable focus is placed on new laser-mediated systems for the effective micro-manipulation of single fetal cells, as well as their analysis by single-cell PCR and the pitfalls to avoid when performing such analyses. Other issues addressed in depth include: novel enrichment techniques, optimal fetal cell recognition, fetal cell culture, as well as the exciting finding that fetal cell traffic is elevated in certain pregnancy-related disorders, most prominently in preeclampsia. This publication is of interest to researchers in the field, genetic counsellors, gynecologists and obstetricians, and researchers in microchimerism, transplantation and transfusion medicine.




Fetal Medicine E-Book


Book Description

Covering pertinent basic science and offering today's most authoritative guidance on clinical management, Fetal Medicine, 3rd Edition, is a must-have resource for obstetricians and other healthcare professionals involved in care of the fetus. An international team of expert contributors delivers the knowledge and background you need to effectively diagnose and treat fetal disorders – everything from prenatal screening and diagnostic tests to common and rare prenatal conditions, early pregnancy loss, ethical issues, and much more. - Focuses on fetal medicine throughout, bringing you today's most reliable information in both basic science and clinical topics. - Offers updated information from cover to cover, including new coverage of genetics, embryology, and clinical management. - Features new self-assessment questions and new images throughout – for a total of nearly 1,000 photographs and line drawings, as well as more than 150 quick-reference tables. - Details fast-changing developments in fetal medicine, including advances in ultrasound imaging, cytogenetics, molecular biology, and biochemistry. - Helps you learn and retrieve complex information quickly thanks to succinct, highly structured text; key points at the beginning of each chapter; and concise chapter summaries. New editor team – 3 new editors with an international approach – they will select qualified authors who can discuss the basic science as well as the clinical aspects of perinatal problems Updated knowledge content – major areas of change are non-invasive prenatal testing (NIPT) and genetic testing – Ron Wapner is one of the leaders in these fields Expert Consult access – individual electronic access for the first time 4-color design – current design is b&w so will update with new colors and colorize the drawings.




The Human Placenta


Book Description

The placenta is fascinating and complex. Basically foreign to the maternal body, it can be thought of as an organ transplanted onto the mother's host tissue. As such it embodies all the principles of tissue acceptance and rejection. Many of the risks of pregnancy and labor have now been eliminated and the placenta is likely to be at the root of many of the dangers to the unborn child that remain. A breakdown of the relationship between the placenta and the maternal tissue may turn out to be the cause of the majority of early lost pregnancies.







The Guide to Investigation of Mouse Pregnancy


Book Description

The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. - Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications - Describes the angiogenic tree the mother's uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes - Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation - Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success




Hematology, Immunology and Infectious Disease: Neonatology Questions and Controversies


Book Description

Hematology, Immunology and Infectious Disease, a volume in Dr. Polin's Neonatology: Questions and Controversies Series, offers expert authority on some of the toughest challenges you face in your practice. This medical reference book will help you provide better evidence-based care and improve patient outcomes with research on the latest advances. Reconsider how you handle difficult practice issues with coverage that addresses these topics head on and offers opinions from the leading experts in the field, supported by evidence whenever possible. Find information quickly and easily with a consistent chapter organization. Get the most authoritative advice available from world-class neonatologists who have the inside track on new trends and developments in neonatal care. Purchase each volume individually, or get the entire 6-volume set, which includes online access that allows you to search across all titles! Stay current in practice with coverage on issues on the pathogenesis, diagnosis, and treatment of neonatal thrombocytopenia, diagnostic technologies in the management of congenital infection, and much more. Access the fully searchable text online at www.expertconsult.com.




Benirschke's Pathology of the Human Placenta


Book Description

This book had its beginning in 1967 when Shirley G. Driscoll and Kurt Benirschke wrote in English the volume on placental pathology for the Henke-Lubarsch, the noted German Handbook of Pathology. There seemed to be a need for wider distribution of the text and it was reprinted by Springer Verlag, New York, essentially the only book available devoted just to the human placenta. Dr. Benirschke authored 5 subsequent editions in collaboration with Peter Kaufmann, Rebecca Baergen and Graham Burton in 1990 (2nd edition), 1995 (3rd edition), 2000 (4th edition), 2006 (5th edition) and 2012 (6th edition). In the early editions, the most important material was in a larger font than the extensive review of exceptions and the discussion in the literature. Since 1967, many other shorter placenta books have been published in English, French and German. None of these have included the breadth of discussion or the voluminous references which includes details of many historic articles, not readily available. Interest in the placenta has wildly expanded over the intervening 50+ years with the vast majority of Pathologists, Obstetricians and Pediatricians recognizing its value. In addition, there are now quite a few new journals, societies and meetings devoted to the placenta in both clinical and research areas. The interest extends into areas of study well beyond the realm of anatomic pathology. The 7th edition will, of necessity, differ from the prior editions which Dr. Benirschke wrote largely himself at first, and later with the help of the above noted co-authors. It will now be an international multi-authored book with nearly 40 contributors revising one or more chapters. The explosion of new information as necessitating some reordering of chapters and adding completely new chapters including Chapters 31 and 32, “Innovations in Placental Pathology” and “Imaging in Placental Pathology”. Dr. Burton’s section has been extensively edited, as well. The editors gave the new authors considerable latitude in how to write the new and/or edited chapters. Many of the revised chapters retain much of Dr. Benirschke’s anecdotal information as well as the voluminous references. Others are more modern in their approach. All contain substantial new references and current information. It is our hope that Benirschke’s Pathology of the Human Placenta will remain as a mainstay reference in placental pathology. It aims to help readers gain a broad understanding of how placental architecture is shaped during normal development, with a view to appreciating how this may be perturbed in complications of pregnancy.




Index Medicus


Book Description

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.




Molecular Genetic Pathology


Book Description

Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.




Pathology of the Placenta


Book Description

This book provides a comprehensive resource on the pathology of the human singleton placenta. Agreed nomenclature, nosology, definitions and, where possible, thresholds for meaningful clinical corrections for lesions ideal for practical application in clinical practice are presented. Evidence is also featured on relevant potential clinical correlations to aid the reader in deciding upon the most appropriate management strategy. Areas of current uncertainty are also covered for potential future research. Pathology of the Placenta systematically describes placental pathology, and represents a valuable resource for practising and trainee pathologists, obstetricians, neonatologists and epidemiologists.