Development of Implantable Electronics as Novel Approaches to Obstructive Sleep Apnea


Book Description

This book addresses novel methods to treat a very popular disease, obstructive sleep apnea, based on a knowledge of an electrical engineering. Two approaches are given in the book using an upper-airway stimulation based on the pathogenesis of an obstructive sleep apnea. Implantable electronics are devised to control the tongue and the soft palate considering that they are the major pharyngeal muscles contributing to the apnea. First, for tongue control, a cuff electrode was designed and fabricated to stimulate the hypoglossal nerve, which innervates to the tongue muscle. Rare-earth magnets were embedded in the cuff for easy and repeatable installation of the electrode. For soft palate control, a palatal implant system was firstly developed to contract the soft palate muscle by applying electrical stimuli. Comprised of an implant, an intra-oral device, and an external controller, the palatal implant system is fully powered and controlled by means of wireless communication. The approaches were demonstrated in both in vitro and in vivo assessments, in collaboration with department of Otorhinolaryngology, Seoul National University Bundang Hospital. .




Development of Implantable Electronics as Novel Approaches to Obstructive Sleep Apnea


Book Description

This book addresses novel methods to treat a very popular disease, obstructive sleep apnea, based on a knowledge of an electrical engineering. Two approaches are given in the book using an upper-airway stimulation based on the pathogenesis of an obstructive sleep apnea. Implantable electronics are devised to control the tongue and the soft palate considering that they are the major pharyngeal muscles contributing to the apnea. First, for tongue control, a cuff electrode was designed and fabricated to stimulate the hypoglossal nerve, which innervates to the tongue muscle. Rare-earth magnets were embedded in the cuff for easy and repeatable installation of the electrode. For soft palate control, a palatal implant system was firstly developed to contract the soft palate muscle by applying electrical stimuli. Comprised of an implant, an intra-oral device, and an external controller, the palatal implant system is fully powered and controlled by means of wireless communication. The approaches were demonstrated in both in vitro and in vivo assessments, in collaboration with department of Otorhinolaryngology, Seoul National University Bundang Hospital.




A Novel Approach in the Detection of Obstructive Sleep Apnea from Electrocardiogram Signals Using Neural Network Classification of Textural Features Extracted from Time-frequency Plots


Book Description

Sleep-Disordered Breathing (SDB) is estimated to have a prevalence of 5% in middle-aged population. The population is widely thought to be under diagnosed, since the present method to detect and diagnose SDB, Nocturnal Polysomnography (NPSG), is still expensive and not accessible by most. SDB has been shown to affect the productivity and degree of life of the patient, and to have a high correlation with obesity and cognitive heart failure (CHF). Cheap and accessible means to screen the population for SDB are greatly pursued. This work presents an automatic algorithm to detect obstructive sleep apnea (OSA) events in 15-minute clips. Data is collected from 12 normal subjects (6 males, 6 females; age 46.27+/-9.79 years, AHI 3.82+/-3.25) and 14 apneic subjects (8 males, 6 females; age 49.08+/-8.82 years; AHI 31.21+/-23.90). The algorithm uses textural features extracted from co-occurrence matrices of gray-level encoded images generated by short-time discrete Fourier transform (STDFT) of the heart rate variability (HRV). Seventeen selected features are used as inputs to a 3-layer multilayer perceptron (MLP), with 45 hidden units and 4200 training epochs. A 1000-run Monte-Carlo simulation of the algorithm gave the following results: mean training sensitivity, specificity and accuracy of 99.00%, 93.42%, and 96.42%, respectively. The mean testing sensitivity, specificity and accuracy are 94.42%, 85.40%, and 90.16%, respectively.




The ASCRS Textbook of Colon and Rectal Surgery


Book Description

This book serves as a valuable resource for surgeons and health care providers at all stages of their career caring for patients with colorectal disease. This edition provides all newly written chapters, organized around the “pillars” of colorectal disease: perioperative (including endoscopy); anorectal disease; benign disease (including inflammatory bowel disease); malignancy; pelvic floor disorders; and a “miscellaneous” section that covers aspects both inside and beyond the operating room. Chapters are formatted to follow that of a “how to” manual as well as an algorithm-based guide to allow the reader to understand the thought process behind a proposed treatment strategy. By making use of evidence-based recommendations, each chapter includes not only background information and diagnostic/therapeutic guidelines, but also provides operative technical details and perioperative “tips and tricks” that are utilized in the management of these complex surgical challenges. Chapters also include the assessment of risk and methods utilized to minimize perioperative complications. In addition, the book incorporates sections covering the medical and surgical therapies for abdominal, pelvic and anorectal disease. Written by experts in the field from around the world, The ASCRS Textbook of Colon and Rectal Surgery 4th Edition exposes the many critical gaps in our knowledge base and inspires the next generation to answer them through thoughtful and high level scientific inquiry.




Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society


Book Description

These proceedings cover such topics as: cardiovascular and respiratory systems; imaging and image processing; micro and nanotechnologies in medicine and biology; information technology in BME; neuromuscular systems and rehabilitation engineering; and management and telemedicine.




American Society for Artificial Internal Organs (ASAIO) Platinum 70th Anniversary Special Edition


Book Description

This book celebrates two decades of groundbreaking research published in the ASAIO Journal, marking significant advancements in artificial organs and circulatory support. The American Society for Artificial Internal Organs ASAIO Platinum 70th Anniversary book is a compilation of 50 of the top papers published in the ASAIO Journal over the last two decades that have contributed to the evolution of the field. The book includes tables listing the Top 100- cited, viewed, and downloaded, articles from the ASAIO Journal. It also lists the Top 10 Altmetric Scores by Year, 2015-2024. Topics range from artificial vision for the blind, and control systems for blood glucose, to the development of an artificial placenta IV and engineering 3D bio-artificial heart muscle, and much more. This book represents early ideas and concepts, new treatments and devices that changed future clinical care and some early concepts that challenge the status quo. With contributions from leading experts, the ASAIO 70th Anniversary Book serves as a comprehensive resource for anyone interested in the forefront of artificial organ technology and its impact on improving patient outcomes. This book is intended for clinicians, scientists, engineers, and academics working for the advancement and development of innovative medical device technologies.




Drug-Induced Sleep Endoscopy


Book Description

The definitive resource on the innovative use of DISE for obstructive sleep apnea Obstructive sleep apnea is the most prevalent sleep-related breathing disorder, impacting an estimated 1.36 billion people worldwide. In the past, OSA was almost exclusively treated with Continuous Positive Airway Pressure (CPAP), however, dynamic assessment of upper airway obstruction with Drug-Induced Sleep Endoscopy (DISE) has been instrumental in developing efficacious alternatives. Drug-Induced Sleep Endoscopy: Diagnostic and Therapeutic Applications by Nico de Vries, Ottavio Piccin, Olivier Vanderveken, and Claudio Vicini is the first textbook on DISE written by world-renowned sleep medicine pioneers. Twenty-four chapters feature contributions from an impressive group of multidisciplinary international experts. Foundational chapters encompass indications, contraindications, informed consent, organization and logistics, patient preparation, and drugs used in DISE. Subsequent chapters focus on treatment outcomes, the role of DISE in therapeutic decision making and upper airway stimulation, pediatric sleep endoscopy, craniofacial syndromes, advanced techniques, and more. Key Highlights Comprehensive video library highlights common and rare DISE findings A full spectrum of sleep disordered breathing and OSA topics, from historic to future perspectives Insightful clinical pearls on preventing errors and managing complications including concentric and epiglottis collapse Discussion of controversial DISE applications including oral appliances and positional and combination therapies This unique book is essential reading for otolaryngology residents, fellows, and surgeons. Clinicians in other specialties involved in sleep medicine will also benefit from this reference, including pulmonologists, neurologists, neurophysiologists, maxillofacial surgeons, and anesthesiologists.




The Intensive Care Unit Manual


Book Description

Intensive Care Unit Manual is a practical, hands-on, how-to manual that covers the full spectrum of conditions encountered in the ICU, guiding you step-by-step from your initial approach to the patient through diagnosis and treatment. Compact, affordable, and comprehensive, the ICU Manual puts all the critical care information you need right at your fingertips! Stay at the forefront of critical care with a practice-oriented, relevant, and well-illustrated account of the pathophysiology of critical disease, presented in a highly readable format. Gain valuable insight into the recognition, evaluation, and management of critical conditions such as respiratory, hemodynamic, and infectious diseases; management of ICU patients with special clinical conditions; cardiovascular, hematologic, and neurological disorders; poisoning and overdoses; trauma and burns; and much more! Grasp the latest developments in critical care with extensive updates and revisions to several key chapters, as well as brand-new chapters on Alcohol Withdrawal Syndromes; Acute Heart Failure Syndromes; Noninvasive Ventilation; and more ICU conditions. Understand and apply the most important ICU practices, including management of acute respiratory failure, mechanical ventilation, invasive hemodynamic monitoring, and the care of patients with special needs, AIDS, end-stage renal disease, or end-stage liver disease. Get convenient access to the full text and image library online at Expert Consult, in addition to online-only text, figures, and tables from the Alcohol Withdrawal Syndromes and Acute Heart Failure Syndromes chapters.




Index Medicus


Book Description

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.




Sleep Apnea


Book Description

Sleep medicine is developing rapidly with more than 100 sleep disorders discovered till now. Despite that, sleep specialty is in neonatal stage especially in developing and underdeveloped countries. Sleep medicine is still evolving with ongoing worldwide clinical research, training programs, and changes in the insurance policy disseminating more awareness in physicians and patients. Sleep apnea is one of the most common sleep disorders, found in around 5-7 % of the general population with high prevalence in the obese, elderly individuals but largely unrecognized and hence undiagnosed with untreated and life-threatening consequences. In the last decade, new complex sleep disorders and their pathophysiology have been discovered, new treatment options (pharmacological and nonpharmacological) are available, and hence we planned a book on the recent developments on the most common sleep disorder, sleep apnea. We have incorporated chapters from the eminent clinicians and authors around the globe to produce a state-of-the-art book with the target audience from internal medicine, pulmonary, sleep medicine, neurology, ENT, and psychiatry discipline.