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Discovering Biomolecular Mechanisms with Computational Biology

Author : Frank Eisenhaber

Publisher : Springer Science & Business Media

Page : 152 pages

File Size : 41,61 MB

Release : 2007-03-20

Category : Science

ISBN : 0387367470

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Book Description

This anthology presents critical reviews of methods and high-impact applications in computational biology that lead to results that non-bioinformaticians must also know to design efficient experimental research plans. Discovering Biomolecular Mechanisms with Computational Biology explores the methodology of translating sequence strings into biological knowledge and considers exemplary groundbreaking results such as unexpected enzyme discoveries. This book also summarizes non-trivial theoretical predictions for regulatory and metabolic networks that have received experimental confirmation.



Mechanism and Causality in Biology and Economics

Author : Hsiang-Ke Chao

Publisher : Springer Science & Business Media

Page : 256 pages

File Size : 27,43 MB

Release : 2013-07-31

Category : Philosophy

ISBN : 9400724543

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Book Description

This volume addresses fundamental issues in the philosophy of science in the context of two most intriguing fields: biology and economics. Written by authorities and experts in the philosophy of biology and economics, Mechanism and Causality in Biology and Economics provides a structured study of the concepts of mechanism and causality in these disciplines and draws careful juxtapositions between philosophical apparatus and scientific practice. By exploring the issues that are most salient to the contemporary philosophies of biology and economics and by presenting comparative analyses, the book serves as a platform not only for gaining mutual understanding between scientists and philosophers of the life sciences and those of the social sciences, but also for sharing interdisciplinary research that combines both philosophical concepts in both fields. The book begins by defining the concepts of mechanism and causality in biology and economics, respectively. The second and third parts investigate philosophical perspectives of various causal and mechanistic issues in scientific practice in the two fields. These two sections include chapters on causal issues in the theory of evolution; experiments and scientific discovery; representation of causal relations and mechanism by models in economics. The concluding section presents interdisciplinary studies of various topics concerning extrapolation of life sciences and social sciences, including chapters on the philosophical investigation of conjoining biological and economic analyses with, respectively, demography, medicine and sociology.



Discovering Biomolecular Mechanisms with Computational Biology

Author : Frank Eisenhaber

Publisher : Springer

Page : 147 pages

File Size : 10,53 MB

Release : 2006-06-13

Category : Medical

ISBN : 9780387345277

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Book Description

This anthology presents critical reviews of methods and high-impact applications in computational biology that lead to results that non-bioinformaticians must also know to design efficient experimental research plans. Discovering Biomolecular Mechanisms with Computational Biology explores the methodology of translating sequence strings into biological knowledge and considers exemplary groundbreaking results such as unexpected enzyme discoveries. This book also summarizes non-trivial theoretical predictions for regulatory and metabolic networks that have received experimental confirmation.



Bioinformatics for Systems Biology

Author : Stephen Krawetz

Publisher : Springer Science & Business Media

Page : 623 pages

File Size : 50,75 MB

Release : 2008-12-11

Category : Science

ISBN : 1597454400

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Book Description

Bioinformatics for Systems Biology bridges and unifies many disciplines. It presents the life scientist, computational biologist, and mathematician with a common framework. Only by linking the groups together may the true life sciences revolution move forward.



The Commodification of Academic Research

Author : Hans Radder

Publisher : University of Pittsburgh Press

Page : 361 pages

File Size : 39,87 MB

Release : 2010-09-05

Category : Philosophy

ISBN : 0822977583

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Book Description

Selling science has become a common practice in contemporary universities. This commodification of academia pervades many aspects of higher education, including research, teaching, and administration. As such, it raises significant philosophical, political, and moral challenges. This volume offers the first book-length analysis of this disturbing trend from a philosophical perspective and presents views by scholars of philosophy of science, social and political philosophy, and research ethics. The epistemic and moral responsibilities of universities, whether for-profit or nonprofit, are examined from several philosophical standpoints. The contributors discuss the pertinent epistemological and methodological questions, the sociopolitical issues of the organization of science, the tensions between commodified practices and the ideal of "science for the public good," and the role of governmental regulation and personal ethical behavior. In order to counter coercive and corruptive influences of academic commodification, the contributors consider alternatives to commodified research and offer practical recommendations for establishing appropriate research standards, methodologies and institutional arrangements, and a corresponding normative ethos.





Genesis - In The Beginning

Author : Joseph Seckbach

Publisher : Springer Science & Business Media

Page : 911 pages

File Size : 38,19 MB

Release : 2012-03-19

Category : Science

ISBN : 9400729413

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Book Description

Genesis – In The Beginning deals with the origin and diversity of Life and early biological evolution and discusses the question of where (hot or cold sources) and when the beginning of Life took place. Among the sections are chapters dealing with prebiotic chemical processes and considering self-replication of polymers in mineral habitats. One chapter is dedicated to the photobiological regime on early Earth and the emergence of Life. This volume covers the role of symmetry, information and order (homochrial biomolecules) in the beginning of Life. The models of protocells and the genetic code with gene transfer are important topics in this volume. Three chapters discuss the Panspermia hypothesis (to answer “Are we from outer Space?”). Other chapters cover the Astrobiological aspects of Life in the Universe in extraterrestrial Planets of the Solar System and deal with cometary hydrosphere (and its connection to Earth). We conclude with the history and frontiers of Astrobiogy.



Stress-Activated Protein Kinases

Author : Francesc Posas

Publisher : Springer Science & Business Media

Page : 322 pages

File Size : 30,68 MB

Release : 2008-01-24

Category : Science

ISBN : 3540755691

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Book Description

In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signaling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. Written by international experts, the book will appeal to cell biologists and biochemists.



Omics in Clinical Practice

Author : Yu Liu

Publisher : CRC Press

Page : 466 pages

File Size : 17,38 MB

Release : 2014-06-20

Category : Science

ISBN : 1771880600

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Book Description

This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics. The topic of companion diagnostics is also covered. The book is broken into five sections. Part I examines the connection between omics and human disease. Part II looks at the applications for the fields of translational and personalized medicine. Part III focuses on molecular and genetic markers. Part IV describes the use of omics while studying pathogens, and Part V examines the applications for companion diagnostics. The book: • Introduces genomics, proteomics, and transcriptomics in relation to human disease and ailments • Considers the role of translation and personalized medicine in relation to genomics, proteomics, and transcriptomics • Covers molecular and genetic markers • Considers the role of genomics, proteomics, and transcriptomics in relation to pathogen detection, evolution, and infection • Covers companion diagnostics in relation to genomics, proteomics, and transcriptomics clinical applications and research



The Codes of Life

Author : Marcello Barbieri

Publisher : Springer Science & Business Media

Page : 443 pages

File Size : 23,31 MB

Release : 2007-10-26

Category : Science

ISBN : 1402063407

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Book Description

Building on a range of disciplines – from biology and anthropology to philosophy and linguistics – this book draws on the expertise of leading names in the study of organic, mental and cultural codes brought together by the emerging discipline of biosemiotics. The volume represents the first multi-authored attempt to deal with the range of codes relevant to life, and to reveal the ubiquitous role of coding mechanisms in both organic and mental evolution.