Colloidal Dispersions


Book Description

This book covers the physical side of colloidal science from the individual forces acting between particles smaller than a micrometer that are suspended in a liquid, through the resulting equilibrium and dynamic properties. A variety of internal forces both attractive and repulsive act in conjunction with Brownian motion and the balance between them all decides the phase behaviour. On top of this various external fields, such as gravity or electromagnetic fields, diffusion and non-Newtonian rheology produce complex effects, each of which is of important scientific and technological interest. The authors aim to impart a sound, quantitative understanding based on fundamental theory and experiments with well-characterised model systems. This broad grasp of the fundamentals lends insight and helps to develop the intuitive sense needed to isolate essential features of the technological problems and design critical experiments. The main prerequisites for understanding the book are basic fluid mechanics, statistical mechanics and electromagnetism, though self contained reviews of each subject are provided at appropriate points. Some facility with differential equations is also necessary. Exercises are included at the end of each chapter, making the work suitable as a textbook for graduate courses in chemical engineering or applied mathematics. It will also be useful as a reference for individuals in academia or industry undertaking research in colloid science.




Rheology of Dispersions


Book Description

A dispersion is a system of unmixable phases in which one phase is continuous and at least one is finely distributed. Examples are found in many industrial applications, including emulsions, suspensions, foams, and geld. The control of their flow characteristics - rheology - is essential in their preparation, long-term physical stability and application. Filling the need for a practical, up-to-date book connecting the stability/instability of the dispersion to its rheological behavior, this title aids in understanding the principles of rheology and the techniques that can be applied. From the contents: * General Introduction * Interparticle Interactions and Their Combination * Principles of Viscoelastic Behavior * Rheology of Suspensions * Rheology of Emulsions * Rheology of Modifiers, Thickeners, and Gels * Use of Rheological Measurements for Assessment and Prediction of the Long-Term Physical Stability of Formulations (Creaming and Sedimentation)




Dispersions


Book Description

Explaining principles essential for the interpretation of data and understanding the real meaning of the result, this work describes carious methods and techniques used to characterize dispersions and measure their physical and chemical properties. It describes a variety of dispersions containing particles ranging from submicron sizes to aggregates and from hard particles to polymer latices.




Amorphous Solid Dispersions


Book Description

This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.




Pharmaceutical Solid Dispersion Technology


Book Description

There has not, until now, been a single up-to-date volume to provide those in drug R&D with practical information on all aspects of solid dispersion technology for drugs. This forthcoming volume finally provides such a guide and reference. The unified presentation by a team of specialists in this field is designed for practical application. Theoretical concepts are covered for a fuller understanding of current techniques. All significant recent developments are included.




Solid - Liquid Dispersions


Book Description

Reviews a range of fundamental concepts, recent developments and practical applications in dispersion theory, along with relevant insights from colloidal and interfacial science. The text contains new work on the stabilization of solid-liquid dispersions. It focuses on topics as varied as electrostatics, hydrodynamics and rheology.




Pharmaceutical Amorphous Solid Dispersions


Book Description

Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology – a leading platform to deliver poorly water soluble drugs, a major hurdle in today’s pharmaceutical industry. • Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems • Covers physical and chemical properties, screening, scale-up, formulation, drug product manufacture, intellectual property, and regulatory considerations • Has an appendix with structure and property information for polymers commonly used in drug development and with marketed drugs developed using the amorphous sold dispersion approach • Addresses global regulatory issues including USA regulations, ICH guidelines, and patent concerns around the world




Polymer Dispersions and Their Industrial Applications


Book Description

Aqueous polymer dispersions are environmentally friendly and therefore they have replaced in many applications polymers dissolved in organic solvents. This substitution process is still ongoing. This book discusses the world of aqueous polymer dispersions from the viewpoint of how they are applied. For a better understanding it starts with a general description of the synthesis of polymer dispersions and their characterization. The following chapters are dedicated to a wide variety of applications, including history, modern processes, and typical formulations and performance. The selection and the usage of a polymer dispersion are not uniform around the world because of historical and regional differences of the technical developments and marketing demands. Leading scientists from industry contributed to this book ensuring that practical issues are emphasized.




Silicone Dispersions


Book Description

Silicone is an important class of materials used in applications that range from industrial assembly to everyday consumer products. Silicones are often delivered and synthesized in dispersion forms, the most common being liquid-in-liquid (emulsion), solid-in-liquid (suspension), air-in-liquid (foam) and solid-in air (powder). This book compiles a carefully selected number of topics that are essential to the understanding, creative design and production of silicone dispersions. As such, it provides the first unified description of silicone dispersions in the literature.




Polymeric Dispersions: Principles and Applications


Book Description

A comprehensive and up to date survey of the science and technology of polymeric dispersions. The book discusses the kinetics and mechanisms of polymerization in dispersed media, examines the processes controlling particle morphology, presents both off-line and on-line methods for the characterization of polymer colloids, considers reactor engineering and control, and covers a wide variety of applications, such as latex paint formulations, encapsulation of inorganic particles, reactive latexes, adhesives, paper coating, and biomedical and pharmaceutical applications. Audience: A valuable resource for scientists and engineers, academic and industrial, who are involved in the manufacture or application of polymeric dispersions.