Toxicological Profile for Chlorine Dioxide


Book Description

Characterizes the toxicologic and adverse health effects (AHE) info. for chlorine dioxide (CD), a hazardous gas that is used as a bleach at paper pulp mills, and in public water-treatment facilities. This profile includes: (A) exam¿n. and interpretation of available toxicologic info. and epidemiologic evaluations on CD to ascertain the levels of significant human exposure and the assoc. chronic health effects; (B) A determination of whether adequate info. on the health effects of CD is avail. to determine levels of exposure that present a significant risk to human health of acute, subacute, and chronic health effects; and (C) Identification of toxicologic testing needed to identify the types or levels of exposure that may present significant risk of AHE in humans. Charts and tables.







Taking an Exposure History


Book Description




Chlorine Dioxide (gas)


Book Description

Chlorine dioxide (ClO2) exists as a greenish yellow to orange gas at room temperature. It is used in the paper and pulp bleaching industries as a sterilizing agent, in hospitals as a biocide in water treatment, and as an improving agent in flour. This document focuses on exposures via routes relevant to occupational settings principally related to the production of chlorine dioxide, but also contains environmental information. The health effects and environmental fate and effects of chlorine dioxide used in the treatment of drinking-water, together with those of halogenated organics produced by the interaction between the disinfectant and other materials present in the water are covered in a recent Environmental Health Criteria publication (EHC No. 216 2000) and are not dealt with in detail here. Chlorine dioxide is an irritant and it seems likely that health effects would be restricted to local responses. The few ecotoxicity data available show that chlorine dioxide can be highly toxic to aquatic organisms.




Toxicological Profile for DDT/DDD/DDE (Update)


Book Description

DDT is a pesticide that was once widely used to control insects. Both DDD and DDE are breakdown products of DDT. This profile includes: (1) The examination, summary, and interpretation of available toxicologic info. and epidemiologic evaluations on DDT/DDD/DDE to ascertain the levels of significant human exposure for the substance and the associated chronic health effects; (2) A determination of whether adequate info. on the health effects of DDT/DDD/DDE is available to determine levels of exposure that present a significant risk to human health of chronic health effects; and (3) Identification of toxicologic testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans. Illus.










Copper in Drinking Water


Book Description

The safety of the nation's drinking water must be maintained to ensure the health of the public. The U.S. Environmental Protection Agency (EPA) is responsible for regulating the levels of substances in the drinking water supply. Copper can leach into drinking water from the pipes in the distribution system, and the allowable levels are regulated by the EPA. The regulation of copper, however, is complicated by the fact that it is both necessary to the normal functioning of the body and toxic to the body at too high a level. The National Research Council was requested to form a committee to review the scientific validity of the EPA's maximum contaminant level goal for copper in drinking water. Copper in Drinking Water outlines the findings of the committee's review. The book provides a review of the toxicity of copper as well as a discussion of the essential nature of this metal. The risks posed by both short-term and long-term exposure to copper are characterized, and the implications for public health are discussed. This book is a valuable reference for individuals involved in the regulation of water supplies and individuals interested in issues surrounding this metal.




Chemical Safety of Drinking-water


Book Description

Contamination of drinking-water is a significant concern for public health throughout the world. Microbial hazards make the largest contribution to waterborne disease in developed and developing countries. Nevertheless, chemicals in water supplies can cause serious health problems--whether the chemicals are naturally occurring or derive from sources of pollution. At a global scale, fluoride and arsenic are the most significant chemicals, each affecting perhaps millions of people. However, many other chemicals can be important contaminants of drinking-water under specific local conditions. Often, identification and assessment of risks to health from drinking-water relies excessively on analysis of water samples. The limitations of this approach are well recognized, and contributed to the delay in recognizing arsenic in drinking-water as a significant health concern in Bangladesh and elsewhere. To overcome such limitations, the latest edition of the World Health Organization (WHO) Guidelines for Drinking-water Quality (WHO, 2004; WHO,2006) emphasizes effective preventive management through a 'framework for drinking-water safety' that incorporates 'water safety plans.' Effective preventive management of chemicals in drinking-water requires simple tools for distinguishing the few chemicals of potential local or national concern from the unmanageably long list of chemicals of possible significance. The aim is to identify and prioritize the chemicals of concern, to overcome the limitations of direct analysis of water quality, and ensure that limited resources are allocated towards the monitoring, assessment and control of the chemicals that pose the greatest health risks. Identifying and prioritizing chemical risks presents a challenge, especially in developing countries, because information on the presence of chemicals in water supplies is often lacking. This document provides guidance to help readers to meet that challenge. It shows how information on aspects such as geology and industrial and agricultural development, which is often readily available, can be used to identify potential chemical contaminants (and potential sources of chemicals), from catchment to consumer, and thus prioritize risks. As a supporting document to the Guidelines for Drinking-water Quality (WHO, 2004; WHO, 2006), this publication is aimed at policy-makers, regulators, managers and public health practitioners at national and local level. It is divided into three parts: Part A provides general guidance on using limited information in prioritizing chemicals in drinking-water for risk management. The need for such guidance is outlined in Chapter 1,which also describes the administrative and policy context. Chapter 2 describes the principles applied in prioritizing chemicals, provides information on some factors that affect chemical concentrations along pathways, and highlights several specific chemicals that are frequently considered priorities because of their widespread occurrence or significant health effects. Chapter 3 discusses the role of drinking-water standards and guidelines, and provides an overview of contemporary water quality management procedures. Part B provides practical guidance on identifying specific chemicals that are likely to be of concern in individual water supply systems. It groups chemical contaminants into five categories on the basis of their potential sources: naturally occurring, from agriculture activities, from human settlements, from industrial activities, and from water treatment and distribution processes themselves. Part C comprises the appendices. It includes guidance on the most likely sources of potential contaminants and on identifying chemicals that could be of concern in particular circumstances. The appendices address potential sources of chemicals considered in the WHO drinking-water guidelines (WHO, 2004; WHO, 2006), chemicals potentially discharged in effluents from industrial sources, and the association of pesticides with crops and crop types. This information is presented in an accessible format that will help users to determine the chemical hazards that can arise in the catchment, in treatment and in distribution, in large, medium and small water supplies. Many experts worldwide contributed to this work over a period of several years, beginning with the 1st Meeting of Experts on Monitoring Chemicals in Drinking Water, held in Bangkok, Thailand, in January 2001. This was followed by the 2nd Meeting of Experts on Monitoring Chemicals in Drinking Water, also held in Bangkok, in December 2001. Both meetings were sponsored by WHO and hosted by the Department of Health, Ministry of Public Health, Thailand. The draft guidance document was subsequently tested in a series of field trials in 2002-2003 in Indonesia, Fiji, Nepal, Mongolia, the Philippines and Thailand. Lessons learnt through the field trials provided feedback that was valuable in revising and finalizing the document. Readers should note that while this publication has been developed as a supporting document for, and with reference to, the Guidelines for Drinking-water Quality, the guidelines themselves are frequently updated and the latest information should always be sought by reference to relevant World Health Organization publications and web site. (http://www.who.int/water_sanitation_health/dwq/guidelines/en/index.html).