Author : Tsuneya Ikezu
Publisher : Springer
Page : 1045 pages
File Size : 29,9 MB
Release : 2016-12-22
Category : Medical
ISBN : 3319440225
The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.
Author : Ronald Ross Watson
Publisher : CRC Press
Page : 256 pages
File Size : 18,95 MB
Release : 1990-07-25
Category : Medical
ISBN : 9780849367472
This important publication provides up-to-date reviews using data from human patients and animal models. The goal is to understand the relationship between immunological modification by drugs of abuse and disease resistance. Examined are the major drugs of abuse and their effects on lymphoid cell function, numbers, development, and interactions. Also addressed are reviews of how ethanol, cocaine, morphine, and marijuana effect the immune function. The book includes evaluations of the relationship of immunomodulation by drugs of abuse on resistance to infectious diseases. This is critical to understanding how drugs modulate diseases and cancer development. This invaluable publication is important to those in biochemistry, physiology, chemistry, biology, immunology, cancer, medicine, pharmacology, microbiology, psychology, psychiatry, and additive studies. It is also of value to those in nutrition, pathology, pediatrics, family medicine, gerontology, surgery, sociology, and anatomy. Specialty groups, such as those in tropical medicine and public policy, will have a strong interest in the book. It is also of significant interest to organizations that deal with major numbers of patients using drugs of abuse and with their associated diseases including AIDS.
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
Page : 487 pages
File Size : 12,88 MB
Release : 2017-03-31
Category : Science
ISBN : 0309453070
Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.
Author : National Research Council
Publisher : National Academies Press
Page : 320 pages
File Size : 23,52 MB
Release : 2004-06-03
Category : Medical
ISBN : 0309166659
New and improved therapies to treat and protect against drug dependence and abuse are urgently needed. In the United States alone about 50 million people regularly smoke tobacco and another 5 million are addicted to other drugs. In a given year, millions of these individuals attemptâ€"with or without medical assistanceâ€"to quit using drugs, though relapse remains the norm. Furthermore, each year several million teenagers start smoking and nearly as many take illicit drugs for the first time. Research is advancing on promising new means of treating drug addiction using immunotherapies and sustained-release (depot) medications. The aim of this research is to develop medications that can block or significantly attenuate the psychoactive effects of such drugs as cocaine, nicotine, heroin, phencyclidine, and methamphetamine for weeks or months at a time. This represents a fundamentally new therapeutic approach that shows promise for treating drug addiction problems that were difficult to treat in the past. Despite their potential benefits, however, several characteristics of these new methods pose distinct behavioral, ethical, legal, and social challenges that require careful scrutiny. Such issues can be considered unique aspects of safety and efficacy that are fundamentally related to the distinct nature and properties of these new types of medications.
Author : Ronald R. Watson
Publisher : CRC Press
Page : 280 pages
File Size : 19,88 MB
Release : 1995-05-04
Category : Medical
ISBN : 9780849383120
Substance abusers are an immunocompromised population, vulnerable to a wide array of new and resurgent infectious diseases - in spite of modern treatment. For example, opportunistic infections like tuberculosis are the principal cause of morbidity and mortality in HIV positive patients. Alcohol- and drug-induced disorders are wide-ranging, gaining prominence as the spectrum of emerging diseases broadens. Alcohol, Drugs of Abuse, and Immune Functions reviews the role of these immunosuppressants as cofactors in disease. It covers the basic biology and immunology of impairments to defense against infectious disease. Alcohol and drug use is consistently associated with immunosuppression, although it isn't known if it is the substance itself, a metabolite, or an indirect effect that alters disease resistance. This text explores the advances toward answering this question, examines alcohol in different settings, its relationship to important cells, and the effects it can have on vital organs such as the liver and the lungs.
Author : Herman Friedman
Publisher : Springer Science & Business Media
Page : 317 pages
File Size : 20,50 MB
Release : 2012-12-06
Category : Medical
ISBN : 1468459252
This volume is based on the program of the International Conference on Drugs of Abuse, Immunity and Immunodeficiency held in Clearwater Beach, Florida. It was sponsored by the University of South Florida College of Medicine with the support of the National Institute on Drug Abuse. During the past few decades, drugs of abuse, including marijuana, cocaine, opiates and alcohol, have been studied by biomedical scientists in terms of the systemic effects of the drugs as well as alterations in neurophysiology and the psychology. More recently, the scope of such investigations has been broadened to include alterations within the immune system, and the influence of altered immunity on physiological and psychological consequences of drug abuse. In this regard, participants in the Clearwater Beach conference provided new information concern ing both basic and clinical aspects of drugs of abuse and immunity, especially immunodeficiency. Advances have been made in recent years in understanding the nature and mechanisms regulating the immune response and the mechanisms by which drugs may influence immune responses. In particular, the emergence of psychoneuroimmunology as a new discipline has heightened interest in immune responses influenced by psychoactive drugs. This has resulted in interdisciplinary investigations involving clinical and basic scientists including microbiologists, immu nologists, physiologists, psychiatrists, oncologists and others. The recreational use of the above mentioned drugs by large numbers of individuals has aroused serious concern about the consequences of this activity.
Author : Herman Friedman
Publisher : CRC Press
Page : 216 pages
File Size : 26,18 MB
Release : 1995-12-18
Category : Medical
ISBN : 9781439805596
During the past few decades, drugs of abuse, including marijuana, cocaine, opiates, and alcohol have been studied in detail by biomedical scientists in terms of their effects on the neurophysiology and psychological responses of individuals. Research over the last few years has provided increased knowledge about possible mechanisms by which such drugs increase the likelihood of infections in humans and experimental animals. In Drugs of Abuse, Immunity, and Infections prominent investigators review important new information concerning the effects of recreational drugs on susceptibility to infection by microorganisms. The volume examines the effects of drugs such as cocaine, morphine, marijuana, and opiates on immunity in humans and animals. It covers the molecular and cellular mechanisms of drug-induced immunosuppression and describes the overall enhanced susceptibility to infection in recreational drug users. It discusses the alteration of susceptibility to the retrovirus that causes the acquired immunodeficiency syndrome (AIDS) and the consensus that drugs of abuse may serve as a possible cofactor in the progression of AIDS. Drugs of Abuse, Immunity, and Infections also includes important information concerning public health aspects of drugs of abuse and infection.
Author : Ota Fuchs
Publisher : BoD – Books on Demand
Page : 248 pages
File Size : 17,17 MB
Release : 2020-05-13
Category : Medical
ISBN : 1789855837
The cells of the immune system are lymphocytes (T-cells, B-cells and NK (natural killer) cells), neutrophils, eosinophils, and monocytes/macrophages. This book is an overview of some types of these cells and their role in recognizing and/or reacting against foreign material. The immune system is characterized by collaboration between cells and proteins. The development of all cells of the immune system begins in the bone marrow with a hematopoietic stem cell. Two chapters deal with neutrophils, three chapters with T-cells, four chapters with eosinophils, and other chapters review the immunomodulation of macrophages, the role of transcription factor KLF4 in regulating plasticity of myeloid-derived suppressor cells, immune reconstitution after allogeneic hematopoietic stem cell transplantation, and role of sorption detoxification in the therapy of acute radiation sickness.
Author : Amitava Dasgupta
Publisher : Academic Press
Page : 544 pages
File Size : 48,3 MB
Release : 2019-01-10
Category : Science
ISBN : 0128156082
Critical Issues in Alcohol and Drugs of Abuse Testing, Second Edition, addresses the general principles and technological advances for measuring drugs and alcohol, along with the pitfalls of drugs of abuse testing. Many designer drugs, for example, are not routinely tested in drugs of abuse panels and may go undetected in a drug test. This updated edition is a must-have for clinical pathologists, toxicologists, clinicians, and medical review officers and regulators, bridging the gap between technical and clinical information. Topics of note include the monitoring of pain management drugs, bath salts, spices (synthetic marijuana), designer drugs and date rape drugs, and more. - Serves as a ready resource of information for alcohol and drug testing - Ideal resource for making decisions related to the monitoring and interpretation of results - Includes concise content for clinical laboratory scientists, toxicologists and clinicians
Author : Adam J. Gordon
Publisher : Cambridge University Press
Page : 397 pages
File Size : 41,36 MB
Release : 2010-03-11
Category : Medical
ISBN : 0521133475
A comprehensive and critical review of recent literature regarding the relationships between physical illness and drugs of abuse, describing the association between each of the principal classes of illicit drugs (cocaine, marijuana, opioids, and common hallucinogens and stimulants) and the major categories of physical illness.
