The LINC Complex
Author : Gregg G. Gundersen
Publisher :
Page : 338 pages
File Size : 25,48 MB
Release : 2018
Category : Cytoskeleton
ISBN : 9781493986910
The Extracellular Matrix
Author : Davide Vigetti
Publisher : Humana Press
Page : 278 pages
File Size : 43,44 MB
Release : 2019-03-31
Category : Science
ISBN : 9781493991327
Book Description
This volume details established experimental protocols on the isolation, characterization, and detection of extracellular matrix (ECM) molecules as well as methods to study the activity and role of ECM components on various biological functions, the formation of exosomes, and tissue surrogates. Chapters display a variety of protocols ranging from biochemical, cell, and molecular biology assays to complex tissue imaging techniques and in vivo models to elucidate the role of the extracellular matrix. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Extracellular Matrix: Methods and Protocols aims to provide protocols and applications that can be used by both Ph.D. students and senior researchers to advance research in the field of extracellular matrix biology.
Cancer Biology and the Nuclear Envelope
Author : Eric C. Schirmer
Publisher : Springer Science & Business Media
Page : 610 pages
File Size : 16,74 MB
Release : 2014-02-22
Category : Medical
ISBN : 1489980326
Book Description
"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."
Molecular Architecture and Dynamics of Meiotic Chromosomes
Author : Ricardo Benavente
Publisher : Frontiers Media SA
Page : 227 pages
File Size : 16,84 MB
Release : 2024-03-11
Category : Science
ISBN : 2832546021
Book Description
Meiosis is a special type of cell division that allows the generation of haploid gametes and is a key process for sexual reproduction of animals, plants and fungi. Haploidization requires that meiotic cells undergo a series of unique processes; namely, pairing, synapsis, recombination and segregation of homologous chromosomes. This involves profound meiosis-specific changes in the protein composition and architecture of homologous chromosomes as well as of the condensation and folding of chromatin that require a critical timing and regulation. Despite this enormous complexity, different organisms may achieve haploidization through common molecular mechanisms. A major goal of this article collection is to provide an overview of how meiotic chromosomes and their components are critically involved in the mechanisms of haploidization and how dynamic protein complexes yield important structural intermediates and temporal regulation to this process. We welcome submissions of original articles, mini-reviews and review articles dealing with the composition, architecture, function and regulation of meiotic chromosomes of animals, plants and fungi using microscopic, biochemical, molecular, genetic and/or ‘omic’ techniques.
Physics of Continuous Matter, Second Edition
Author : B. Lautrup
Publisher : CRC Press
Page : 698 pages
File Size : 29,18 MB
Release : 2011-03-22
Category : Science
ISBN : 1420077007
Book Description
Physics of Continuous Matter: Exotic and Everyday Phenomena in the Macroscopic World, Second Edition provides an introduction to the basic ideas of continuum physics and their application to a wealth of macroscopic phenomena. The text focuses on the many approximate methods that offer insight into the rich physics hidden in fundamental continuum mechanics equations. Like its acclaimed predecessor, this second edition introduces mathematical tools on a "need-to-know" basis. New to the Second Edition This edition includes three new chapters on elasticity of slender rods, energy, and entropy. It also offers more margin drawings and photographs and improved images of simulations. Along with reorganizing much of the material, the author has revised many of the physics arguments and mathematical presentations to improve clarity and consistency. The collection of problems at the end of each chapter has been expanded as well. These problems further develop the physical and mathematical concepts presented. With worked examples throughout, this book clearly illustrates both qualitative and quantitative physics reasoning. It emphasizes the importance in understanding the physical principles behind equations and the conditions underlying approximations. A companion website provides a host of ancillary materials, including software programs, color figures, and additional problems.
Tissue Morphogenesis
Author : Celeste M. Nelson
Publisher : Springer Nature
Page : 235 pages
File Size : 41,13 MB
Release :
Category :
ISBN : 1071638548
Book Description
Cytoskeletal Dynamics and Mechanics in Cell Growth, Division, Differentiation and Aging
Author : Ting Gang Chew
Publisher : Frontiers Media SA
Page : 151 pages
File Size : 48,3 MB
Release : 2022-01-25
Category : Science
ISBN : 2889741605
Book Description
Seeing Color
Author : Jun Xing
Publisher :
Page : 276 pages
File Size : 17,46 MB
Release : 2007
Category : History
ISBN :
Book Description
Indigenous peoples and racial minorities have lived and thrived in Oregon for centuries. Their legacy is interwoven with the state's history and culture even as they continue to struggle with prejudice, environmental pressures, shrinking state revenues, the effects of globalization, and the changing dynamics of the state economy. Current U.S. immigration policy and the forces of globalization have played a critical role in creating a dynamic process named the 'browning of Oregon.' This anthology brings together a group of noted multidisciplinary scholars, who explore the rich and varied experiences of Oregon's native communities and racial minorities. Anchored in a 'power relations' perspective, the book has been organized around several key historical themes, including: the foundation of ethnic communities; civil rights; social justice; ethnicity and labor; and various forms of cultural traditions. As disparate as they seem in style and topic, this collection of essays highlight the distinctive experiences of Oregon's people of color and communicates the broader interlocking categories of social identity. The book is essential reading for students, teachers, and the general public interested in contemporary racial politics.
Simulating Humans
Author : Norman I. Badler
Publisher : Oxford University Press, USA
Page : 287 pages
File Size : 39,39 MB
Release : 1993-09-02
Category : Computers
ISBN : 0195073592
Book Description
The area of simulated human figures is an active research area in computer graphics, and Norman Badler's group at the University of Pennsylvania is one of the leaders in the field. This book summarizes the state of the art in simulating human figures, discusses many of the interesting application areas, and makes some assumptions and predictions about where the field is going.
The Liver
Author : Irwin M. Arias
Publisher : John Wiley & Sons
Page : 1156 pages
File Size : 31,75 MB
Release : 2020-03-09
Category : Medical
ISBN : 1119436826
Book Description
Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
