Electric Field-Induced Effects on Neuronal Cell Biology Accompanying Dielectrophoretic Trapping


Book Description

The concept of the cultured neuron probe was induced by the possible selective stimulation of nerves for functional recovery after a neural lesion or disease. The probe consists of a micro-electrode array on top of which groups of neuronal cells are cultured. An efficient method to position groups of neuronal cells on top of the stimulation sites of the micro-electrode array is developed. With negative dielectrophoretic forces, produced by non-uniform electric fields on polarizable particles, neuronal cells are trapped. Experimental results and model simulations describe the trapping process and its effect on neuronal cell viability.







Index Medicus


Book Description

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.




Electric Field-Induced Effects on Neuronal Cell Biology Accompanying Dielectrophoretic Trapping


Book Description

1. 1 Neuro-Electronic Interfacing 1. 1. 1 Nervous System Communication in the(human) bodyand the interaction with the environment is controlled by the nervous system. It can be divided into a central part, which - cludes the spinal cord, brainstem, cerebellum, and cerebrum, and a peripheral part, which includes all neuronal tissue outside the central part (Martini 2001). The latter provides the interface between the central nervous system and the internal and ext- nal environment of the body. Eye, ear, skin, and muscle sensors provide the nec- sary information. Via primary afferent neurons this information is transmitted to the central nervous system. Conversely,this system provides information to the - tor organs via theefferent fibers. Furthermore, the central nervous system is resp- sible for cognition, learning, and memory. Neurons are cells specialized for receiving information and transmitting signals to other neurons or to effector cells, such as muscles and glands (Levitan 1991). Like all other cells, neurons are enclosed by a cell membrane, which is a double layer of phospholipid molecules. This bilayer, about 10 nm thick, serves as a barrier that - lows the cell to maintain an internal (cytoplasmic) composition far different from the composition of the extracellular fluid. It contains enzymes, receptors, and an- gens that play central roles in the interaction of thecell with other cells.




Brain and Human Body Modeling 2020


Book Description

The 41st Annual International Conference of the IEEE EMBS, took place between July 23 and 27, 2019, in Berlin, Germany. The focus was on "Biomedical engineering ranging from wellness to intensive care." This conference provided an opportunity for researchers from academia and industry to discuss a variety of topics relevant to EMBS and hosted the 4th Annual Invited Session on Computational Human Models. At this session, a bevy of research related to the development of human phantoms was presented, together with a substantial variety of practical applications explored through simulation.




Microscale Acoustofluidics


Book Description

The manipulation of cells and microparticles within microfluidic systems using external forces is valuable for many microscale analytical and bioanalytical applications. Acoustofluidics is the ultrasound-based external forcing of microparticles with microfluidic systems. It has gained much interest because it allows for the simple label-free separation of microparticles based on their mechanical properties without affecting the microparticles themselves. Microscale Acoustofluidics provides an introduction to the field providing the background to the fundamental physics including chapters on governing equations in microfluidics and perturbation theory and ultrasound resonances, acoustic radiation force on small particles, continuum mechanics for ultrasonic particle manipulation, and piezoelectricity and application to the excitation of acoustic fields for ultrasonic particle manipulation. The book also provides information on the design and characterization of ultrasonic particle manipulation devices as well as applications in acoustic trapping and immunoassays. Written by leading experts in the field, the book will appeal to postgraduate students and researchers interested in microfluidics and lab-on-a-chip applications.




Ferroelectrics


Book Description

Ferroelectric materials have been and still are widely used in many applications, that have moved from sonar towards breakthrough technologies such as memories or optical devices. This book is a part of a four volume collection (covering material aspects, physical effects, characterization and modeling, and applications) and focuses on the application of ferroelectric devices to innovative systems. In particular, the use of these materials as varying capacitors, gyroscope, acoustics sensors and actuators, microgenerators and memory devices will be exposed, providing an up-to-date review of recent scientific findings and recent advances in the field of ferroelectric devices.




Micro Total Analysis Systems


Book Description

The use of silicon-based microsystems for chemical analysis is one of the most promising concepts in the recent developments in micro system technology (MST). It is expected that chemical sensors will be increasingly integrated in so-called miniaturized total analysis systems (muTAS), a concept first presented by Ciba-Geigy. In such systems, all steps in a chemical determination, from sampling to detection and data treatment, are integrated in one miniature instrument. muTAS offer a variety of advantages over conventional analysis systems such as improved analytical performance, reduced reagent and power consumption, small size, possibility of new and more complicated functions, higher reliability and lower fabrication costs. Application of muTAS may be found in fields like process industry, environmental monitoring, medical diagnostics, aeronautics, automotive industry, etc.




Low-Frequency Electromagnetic Modeling for Electrical and Biological Systems Using MATLAB


Book Description

Provides a detailed and systematic description of the Method of Moments (Boundary Element Method) for electromagnetic modeling at low frequencies and includes hands-on, application-based MATLAB® modules with user-friendly and intuitive GUI and a highly visualized interactive output. Includes a full-body computational human phantom with over 120 triangular surface meshes extracted from the Visible Human Project® Female dataset of the National library of Medicine and fully compatible with MATLAB® and major commercial FEM/BEM electromagnetic software simulators. This book covers the basic concepts of computational low-frequency electromagnetics in an application-based format and hones the knowledge of these concepts with hands-on MATLAB® modules. The book is divided into five parts. Part 1 discusses low-frequency electromagnetics, basic theory of triangular surface mesh generation, and computational human phantoms. Part 2 covers electrostatics of conductors and dielectrics, and direct current flow. Linear magnetostatics is analyzed in Part 3. Part 4 examines theory and applications of eddy currents. Finally, Part 5 evaluates nonlinear electrostatics. Application examples included in this book cover all major subjects of low-frequency electromagnetic theory. In addition, this book includes complete or summarized analytical solutions to a large number of quasi-static electromagnetic problems. Each Chapter concludes with a summary of the corresponding MATLAB® modules. Combines fundamental electromagnetic theory and application-oriented computation algorithms in the form of stand alone MATLAB® modules Makes use of the three-dimensional Method of Moments (MoM) for static and quasistatic electromagnetic problems Contains a detailed full-body computational human phantom from the Visible Human Project® Female, embedded implant models, and a collection of homogeneous human shells Low-Frequency Electromagnetic Modeling for Electrical and Biological Systems Using MATLAB® is a resource for electrical and biomedical engineering students and practicing researchers, engineers, and medical doctors working on low-frequency modeling and bioelectromagnetic applications.




Electrical Properties of Cells


Book Description

DeFelice presents this intricate subject in an easy-to-follow, stepwise fashion: he reviews the fundamentals of electricity; transfers those principles to a biological context; and expands the discussion to encompass the subject's practical dimensions. Clear definitions and intuitive descriptions characterize the presentation, which is complemented by over 150 drawings and graphs. Mathematics is kept to the minimum necessary. The text covers both excitable and non-excitable membranes and includes the plasma membrane as well as intracellular membranes. A unique, `electronics-made-simple' appendix, designed specifically for biologists, treats the operational amplifiers used in patch clamp, and other appendices offer solutions to equations and examples that illustrate principles.