Female Reproductive Dysfunction


Book Description

Written by leading international specialists, this book provides a comprehensive, state-of-the-art overview of endocrine-based female reproductive disorders. Particularly focusing on the Hypothalamus – Pituitary – Ovary (HPO) axis as the main driver of reproduction in women, it discusses amenorrhea; chronic anovulation and polycystic ovary syndrome as the most common dysfunctions of the HPO axis; endocrine diseases as possible impacts on the HPO axis; uterine disorders related to estrogen/progesterone; and the impact of endometriosis and uterine fibroids on reproduction. It also addresses infertility and menopause as hormone-related disorders in women and endocrine changes during pregnancy and lactation, and in breast disorders. The book is intended as a major reference for endocrinologists, gynecologists, and obstetricians, as well as basic and clinical scientists. It is published as part of the SpringerReference program, which provides access to live editions constantly updated through a dynamic peer-review publishing process.




Kisspeptin Signaling in Reproductive Biology


Book Description

Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood. This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known. The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function. Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis.




Exploring the Biological Contributions to Human Health


Book Description

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.




Brain Aromatase, Estrogens, and Behavior


Book Description

This book concerns how estrogens are synthesized in the brain and their two modes of action on behavior: a slow process involving gene transcription and a faster action at the cell membrane. The significance of the regulation and distribution of the estrogen synthesizing enzyme aromatase in the brain is also highlighted.




Hormones and Social Behavior


Book Description

This book concentrates on two major topics: firstly, the molecular and neural biology of hormone actions relevant to normal social behaviors; and secondly, the clinical treatment of human patients in whom these behaviors have gone wrong.




Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes


Book Description

The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.




Offspring


Book Description

Despite recent advances in our understanding of the genetic basis of human behavior, little of this work has penetrated into formal demography. Very few demographers worry about how biological processes might affect voluntary behavior choices that have demographic consequences even though behavioral geneticists have documented genetics effects on variables such as parenting and divorce. Offspring: Human Fertility Behavior in Demographic Perspective brings together leading researchers from a wide variety of disciplines to review the state of research in this emerging field and to identify promising research directions for the future.




Hormones and Aggressive Behavior


Book Description

This volume is an overview of research examining the relationship between hormones and aggressive behavior. The last 15 years have witnessed a tremen dous growth of knowledge in this area, yet reviews written by specialists are virtually nonexistent. This work is an attempt to provide a comprehensive and cohesive synthesis of this literature. Chapters 1-7 provide an analysis of hor monal influences on the major forms of aggressive behavior, including intermale, interfemale, shock-induced, maternal, territorial, and predatory aggression. The focus of Chapters 8-12 is an examination of the mechanisms through which hormones might act to produce changes in agonistic responding. Genetic, de velopmental, neural, and biochemical influences are considered. It is well known that environment, social context, and experience modulate the effects of hor mones on behavior. Thus, Chapters 13-15 are designed to review the literature concerning hormone-pheromone interactions, hormonal responses to compe tition, and the influence of social context on the endocrine system and aggressive behavior. Frequently, the principles advanced by behavioral endocrinologists are based on research in one species, the rodent. To provide a more comparative perspective and to examine specifically the generality of those principles gen erated for rodents, Chapters 16-22 examine hormone-aggression relationships in a variety of species, including fish, birds, amphibians, reptiles, infrahuman primates, humans, ungulates, and insects. This volume should be useful to both beginning and advanced researchers in animal behavior, behavioral endocri nology, physiological psychology, neuroendocrinology, zoology, physiology, and psychiatry.




Sexual Differentiation of the Brain


Book Description

Investigating the relative importance of genes, hormones, and environment in the formation of sexual behavior.