Epigenetics in the Age of Twitter


Book Description

"America's most interesting and important essayist." —Eric Kandel, Nobel Prize–winning author of The Age of Insight "[Gerald Weissmann] bridges the space between science and the humanities, and particularly between medicine and the muses, with wit, erudition, and, most important, wisdom." —Adam Gopnik Epigenetics, which attempts to explain how our genes respond to our environment, is the latest twist on the historic nature vs. nurture debate. In addressing this and other controversies in contemporary science, Gerald Weissmann taps what he calls "the social network of Western Civilization," including the many neglected women of science: from the martyred Hypatia of Alexandria, the first woman scientist, to the Nobel laureates Marie Curie, Christiane Nüsslein-Volhard, and Elizabeth Blackburn, among other luminaries in the field. Always instructive and often hilarious, this is a one-volume introduction to modern biology, viewed through the lens of contemporary mass media and the longer historical tradition of the Scientific Revolution. Whether engaging in the healthcare debate or imagining the future prose styling of the scientific research paper in the age of Twitter, Weissmann proves himself as an incisive cultural critic and satirist. Gerald Weissmann (August 7, 1930 – July 10, 2019) was a physician, scientist, editor, and essayist whose collections include The Fevers of Reason: New and Selected Essays; Epigenetics in the Age of Twitter: Pop Culture and Modern Science; Mortal and Immortal DNA: Science and the Lure of Myth; and Galileo’s Gout: Science in an Age of Endarkenment.




Environmental Epigenetics


Book Description

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.




Innate


Book Description

"What makes you the way you are--and what makes each of us different from everyone else? In Innate, leading neuroscientist and popular science blogger Kevin Mitchell traces human diversity and individual differences to their deepest level: in the wiring of our brains. Deftly guiding us through important new research, including his own groundbreaking work, he explains how variations in the way our brains develop before birth strongly influence our psychology and behavior throughout our lives, shaping our personality, intelligence, sexuality, and even the way we perceive the world. We all share a genetic program for making a human brain, and the program for making a brain like yours is specifically encoded in your DNA. But, as Mitchell explains, the way that program plays out is affected by random processes of development that manifest uniquely in each person, even identical twins. The key insight of Innate is that the combination of these developmental and genetic variations creates innate differences in how our brains are wired--differences that impact all aspects of our psychology--and this insight promises to transform the way we see the interplay of nature and nurture. Innate also explores the genetic and neural underpinnings of disorders such as autism, schizophrenia, and epilepsy, and how our understanding of these conditions is being revolutionized. In addition, the book examines the social and ethical implications of these ideas and of new technologies that may soon offer the means to predict or manipulate human traits. Compelling and original, Innate will change the way you think about why and how we are who we are."--Provided by the publisher.




Epigenetics of Aging


Book Description

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.




The Epigenetics Revolution


Book Description

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.




Play Among Books


Book Description

How does coding change the way we think about architecture? This question opens up an important research perspective. In this book, Miro Roman and his AI Alice_ch3n81 develop a playful scenario in which they propose coding as the new literacy of information. They convey knowledge in the form of a project model that links the fields of architecture and information through two interwoven narrative strands in an “infinite flow” of real books. Focusing on the intersection of information technology and architectural formulation, the authors create an evolving intellectual reflection on digital architecture and computer science.




Modern Psychology and Ancient Wisdom


Book Description

Modern Psychology and Ancient Wisdom, 2nd edition, brings together experts who explore the use of ancient healing techniques from Buddhism, Christianity, Goddess, Shamanism, Taoism, and Yogic traditions as well as the mystical practices of Judaism and Islam and their application to modern counseling and therapy professions. Each chapter lays out time-tested techniques used by teachers, guides, and practitioners to facilitate psychological healing, embraces a wide variety of cultural perspectives, and offers a large, varied, and meaningful view of the world. This new edition includes added material on Islam, indigenous, and shamanic healing perspectives and practices, as well as new findings in the fields of neuropsychology and epigenetics. With its vast offerings of new treatment methods from a variety of perspectives—from therapeutic metaphors and breathing exercises to meditation and yoga techniques—this book will be of use to mental health professionals, social workers, and pastoral caregivers.




The Fevers of Reason


Book Description

"America's most interesting and important essayist." —Eric Kandel, Nobel Prize–winning author of The Age of Insight "[Gerald Weissmann] bridges the space between science and the humanities, and particularly between medicine and the muses, with wit, erudition, and, most important, wisdom." —Adam Gopnik In this diverting collection of essays, Gerald Weissmann looks back on decades of a career spent working at the intersection of the arts and sciences. The Fevers of Reason features some of his best and most representative works, alongside eleven new essays never before published in book form. Masterfully drawing from an array of subject areas and time periods, he tackles everything from Ebola to Eisenhower, Zika to Zola, Darwin to Dawkins, showcasing his singular contribution to humanistic science writing. Gerald Weissmann (August 7, 1930 – July 10, 2019) was a physician, scientist, editor, and essayist whose collections include The Fevers of Reason: New and Selected Essays; Epigenetics in the Age of Twitter: Pop Culture and Modern Science; Mortal and Immortal DNA: Science and the Lure of Myth; and Galileo's Gout: Science in an Age of Endarkenment.




Whole Earth


Book Description

Told by one of our greatest chroniclers of technology and society, the definitive biography of iconic serial visionary Stewart Brand, from the Merry Pranksters and the generation-defining Whole Earth Catalog to the marriage of environmental consciousness and hacker capitalism and the rise of a new planetary culture—the story behind so many other stories Stewart Brand has long been famous if you know who he is, but for many people outside the counterculture, early computing, or the environmental movement, he is perhaps best known for his famous mantra “Stay Hungry. Stay Foolish.” Steve Jobs’s endorsement of these words as his code to live by is fitting; Brand has played many roles, but one of the most important is as a model for how to live. The contradictions are striking: A blond-haired WASP with a modest family inheritance, Brand went to Exeter and Stanford and was an army veteran, but in California in the 1960s he became an artist and a photographer in the thick of the LSD revolution. While tripping on acid on the roof of his building, he envisioned how valuable it would be for humans to see a photograph of the planet they shared from space, an image that in the end landed on the cover of his Whole Earth Catalog, the defining publication of the counterculture. He married a Native American woman and was committed to protecting indigenous culture, which connected to a broader environmentalist mission that has been a through line of his life. At the same time, he has outraged purists because of his pragmatic embrace of useful technologies, including nuclear power, in the fight against climate change. The famous tagline promise of his catalog was “Access to Tools”; with rare exceptions he rejected politics for a focus on direct power. It was no wonder, then, that he was early to the promise of the computer revolution and helped define it for the wider world. Brand's life can be hard to fit onto one screen. John Markoff, also a great chronicler of tech culture, has done something extraordinary in unfolding the rich, twisting story of Brand’s life against its proper landscape. As Markoff makes marvelously clear, the streams of individualism, respect for science, environmentalism, and Eastern and indigenous thought that flow through Brand’s entire life form a powerful gestalt, a California state of mind that has a hegemonic power to this day. His way of thinking embraces a true planetary consciousness that may be the best hope we humans collectively have.




Epigenetic Epidemiology


Book Description

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored.This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!