Epithelial-mesenchymal Interactions in Development
Author : Roger H. Sawyer
Publisher : Greenwood
Page : 280 pages
File Size : 28,79 MB
Release : 1983
Category : Science
ISBN :
Author : Roger H. Sawyer
Publisher : Greenwood
Page : 280 pages
File Size : 28,79 MB
Release : 1983
Category : Science
ISBN :
Author : Itzhak D. Goldberg
Publisher : Birkhäuser
Page : 304 pages
File Size : 36,31 MB
Release : 2013-03-07
Category : Science
ISBN : 3034890702
The contribution of epithelia-mesenchyme interaction to normal development (eg., tissue formation) and to neoplasia has become a subject of increasing interest to scientists because of recent progress in deciphering the molecular signals that mediate this interaction. Clearly, some of the same types of molecules (eg., growth factors and their receptors, proteolytic enzymes, cell adhesion molecules, and structural proteins of the extracellular matrix) mediate exchange of information between epithelia and mesenchyme during normal development and malignant growth. However, defects in the regulation of this exchange appear to contribute to malignancy by allowing growth promoting, invasogenic, and angiogenic factors to accumulate within the microenvironment of the tumor. For example, recent studies suggest that abnormal interactions between tumor epithelial cells and stromal mesenchymal cells contribute to the overproduction and accumulation of scatter factor (hepatocyte growth factor), an invasogenic and angiogenic cytokine, in certain types of tumor. The production and and activation of type IV collagenase, a matrix-degrading enzyme required for tumor cell invasion, appears to require intimate cooperation between tumor and stromal cells. The material contained in this volume highlights the state-of-the-art of knowledge of the molecular mechanisms by which epithelia and mesenchyme collaborate, and the abnormalities in these mechanisms that may lead to the development of cancer.
Author : Itzhak D. Goldberg
Publisher :
Page : 316 pages
File Size : 39,89 MB
Release : 2014-01-15
Category :
ISBN : 9783034890717
Author : Raul Fleischmajer
Publisher :
Page : 326 pages
File Size : 46,81 MB
Release : 1968
Category :
ISBN :
Author : Raul Fleischmajer
Publisher :
Page : 0 pages
File Size : 33,98 MB
Release : 1968
Category :
ISBN :
Author : Betina Chandolia
Publisher :
Page : 92 pages
File Size : 42,81 MB
Release : 2016-07-30
Category :
ISBN : 9783659909221
Author : Sengel
Publisher : CUP Archive
Page : 296 pages
File Size : 34,65 MB
Release : 1976
Category : Medical
ISBN : 9780521206440
Author : Molly Weaver
Publisher :
Page : 436 pages
File Size : 30,40 MB
Release : 2003
Category : Cellular control mechanisms
ISBN :
Author : Raul Fleischmajer (ed)
Publisher :
Page : 348 pages
File Size : 18,78 MB
Release : 1968
Category : Epithelium
ISBN :
Author : Annette M. Marme'
Publisher :
Page : 108 pages
File Size : 10,76 MB
Release : 1986
Category : Epithelium
ISBN :