Essays on Matching and Weighting for Causal Inference in Observational Studies


Book Description

A simulation study with different settings is conducted to compare the proposed weighting scheme to IPTW, including generalized propensity score estimation methods that also consider explicitly the covariate balance problem in the probability estimation process. The applicability of the methods to continuous treatments is also tested. The results show that directly targeting balance with the weights, instead of focusing on estimating treatment assignment probabilities, provides the best results in terms of bias and root mean square error of the treatment effect estimator. The effects of the intensity level of the 2010 Chilean earthquake on posttraumatic stress disorder are estimated using the proposed methodology.




Handbook of Matching and Weighting Adjustments for Causal Inference


Book Description

An observational study infers the effects caused by a treatment, policy, program, intervention, or exposure in a context in which randomized experimentation is unethical or impractical. One task in an observational study is to adjust for visible pretreatment differences between the treated and control groups. Multivariate matching and weighting are two modern forms of adjustment. This handbook provides a comprehensive survey of the most recent methods of adjustment by matching, weighting, machine learning and their combinations. Three additional chapters introduce the steps from association to causation that follow after adjustments are complete. When used alone, matching and weighting do not use outcome information, so they are part of the design of an observational study. When used in conjunction with models for the outcome, matching and weighting may enhance the robustness of model-based adjustments. The book is for researchers in medicine, economics, public health, psychology, epidemiology, public program evaluation, and statistics who examine evidence of the effects on human beings of treatments, policies or exposures.




Essays in Causal Inference


Book Description

In observational studies, identifying assumptions may fail, often quietly and without notice, leading to biased causal estimates. Although less of a concern in randomized trials where treatment is assigned at random, bias may still enter the equation through other means. This dissertation has three parts, each developing new methods to address a particular pattern or source of bias in the setting being studied. In the first part, we extend the conventional sensitivity analysis methods for observational studies to better address patterns of heterogeneous confounding in matched-pair designs. We illustrate our method with two sibling studies on the impact of schooling on earnings, where the presence of unmeasured, heterogeneous ability bias is of material concern. The second part develops a modified difference-in-difference design for comparative interrupted time series studies. The method permits partial identification of causal effects when the parallel trends assumption is violated by an interaction between group and history. The method is applied to a study of the repeal of Missouri's permit-to-purchase handgun law and its effect on firearm homicide rates. In the final part, we present a study design to identify vaccine efficacy in randomized control trials when there is no gold standard case definition. Our approach augments a two-arm randomized trial with natural variation of a genetic trait to produce a factorial experiment. The method is motivated by the inexact case definition of clinical malaria.




Causal Inference


Book Description

A nontechnical guide to the basic ideas of modern causal inference, with illustrations from health, the economy, and public policy. Which of two antiviral drugs does the most to save people infected with Ebola virus? Does a daily glass of wine prolong or shorten life? Does winning the lottery make you more or less likely to go bankrupt? How do you identify genes that cause disease? Do unions raise wages? Do some antibiotics have lethal side effects? Does the Earned Income Tax Credit help people enter the workforce? Causal Inference provides a brief and nontechnical introduction to randomized experiments, propensity scores, natural experiments, instrumental variables, sensitivity analysis, and quasi-experimental devices. Ideas are illustrated with examples from medicine, epidemiology, economics and business, the social sciences, and public policy.




Three Essays on Causal Inference for Observational Studies


Book Description

Finally, the third paper in this thesis addresses the question of unintended consequences in school segregation due to the introduction of a targeted voucher scheme. I use a difference-in-difference approach, in combination with matching on time-stable covariates, to estimate the effect that the 2008 Chilean voucher policy had on both average students' household income and academic performance at the school level. Results show that even though the policy had a positive effect on schools' standardized test scores, closing the gap between schools that subscribed to the policy compared to those that did not, there was also an increase in the differences between socioeconomic characteristics at the school level, such as average household income.




Essays in Causal Inference


Book Description

In Chapter 1, I study the statistical inference problem for treatment assignment policies. In typical applications, individuals with different characteristics are expected to differ in their responses to treatment. As a result, treatment assignment policies that allocate treatment based on individuals' observed characteristics can have a significant influence on outcomes and welfare. A growing literature proposes various approaches to estimating the welfare-optimzing treatment assignment policy. I develop a method for assessing the precision of estimated optimal policies. In particular, for the welfare used by \cite{KT:18} to propose estimated assignment policy, my method constructs (i) a confidence set of policies that contains the optimal policy, which maximizes the average social welfare among all the feasible policies with prespecified level and (ii) a confidence interval for the maximized welfare. A simulation study indicates that the proposed methods work reasonably well with modest sample size. I apply the method to experimental data from the National Job Training Partnership Act study. In Chapter 2, I derive the large sample properties of $M$th nearest neighbor propensity score matching estimator with a potentially misspecified propensity score model. By using the local misspecification framework, I formalize the bias/variance trade-off with respect to the choice of propensity score estimator and propose a model selection criterion that aims to minimize the estimation error. Finally, in Chapter 3 (co-authored with Taisuke Otsu), we propose asymptotically valid inference methods for matching estimators based on the weighted bootstrap. The key is to construct bootstrap counterparts by resampling based on certain linear forms of the estimators. Our weighted bootstrap is applicable for the matching estimators of both the average treatment effect and its counterpart for the treated population. Also, by incorporating a bias correction method in \cite{AI:11}, our method can be asymptotically valid even for matching based on a vector of covariates. A simulation study indicates that the weighted bootstrap method is favorably comparable with the asymptotic normal approximation by \cite{AI:06}. As an empirical illustration, we apply the proposed method to the National Supported Work data.




Causal Inference


Book Description

An accessible, contemporary introduction to the methods for determining cause and effect in the social sciences "Causation versus correlation has been the basis of arguments--economic and otherwise--since the beginning of time. Causal Inference: The Mixtape uses legit real-world examples that I found genuinely thought-provoking. It's rare that a book prompts readers to expand their outlook; this one did for me."--Marvin Young (Young MC) Causal inference encompasses the tools that allow social scientists to determine what causes what. In a messy world, causal inference is what helps establish the causes and effects of the actions being studied--for example, the impact (or lack thereof) of increases in the minimum wage on employment, the effects of early childhood education on incarceration later in life, or the influence on economic growth of introducing malaria nets in developing regions. Scott Cunningham introduces students and practitioners to the methods necessary to arrive at meaningful answers to the questions of causation, using a range of modeling techniques and coding instructions for both the R and the Stata programming languages.




Essays on Causal Inference in Observational Studies


Book Description

The third essay investigates the impact of United Nations peacekeeping following civil war. King and Zeng (2007) found that prior work on this topic (Doyle and Sambanis 2000) had been based more on indefensible modeling assumptions than on evidence. This essay revisits the Doyle and Sambanis (2000) causal questions and answers them using new matching-based methods. These new methods do not require assumptions that plagued prior work, and they are broadly applicable to many important inferential problems in political science and beyond. When the methods are applied to the Doyle and Sambanis (2000) data, there is a preponderance of evidence to suggest that UN peacekeeping has had a positive effect on peace and democracy in the aftermath of civil war.




Observation and Experiment


Book Description

Cover -- Contents -- Preface -- Reading Options -- List of Examples -- Part I. Randomized Experiments -- 1. A Randomized Trial -- 2. Structure -- 3. Causal Inference in Randomized Experiments -- 4. Irrationality and Polio -- Part II. Observational Studies -- 5. Between Observational Studies and Experiments -- 6. Natural Experiments -- 7. Elaborate Theories -- 8. Quasi-experimental Devices -- 9. Sensitivity to Bias -- 10. Design Sensitivity -- 11. Matching Techniques -- 12. Biases from General Dispositions -- 13. Instruments -- 14. Conclusion -- Appendix: Bibliographic Remarks -- Notes -- Glossary: Notation and Technical Terms -- Suggestions for Further Reading -- Acknowledgments -- Index




Replication and Evidence Factors in Observational Studies


Book Description

Outside of randomized experiments, association does not imply causation, and yet there is nothing defective about our knowledge that smoking causes lung cancer, a conclusion reached in the absence of randomized experimentation with humans. How is that possible? If observed associations do not identify causal effects in observational studies, how can a sequence of such associations become decisive? Two or more associations may each be susceptible to unmeasured biases, yet not susceptible to the same biases. An observational study has two evidence factors if it provides two comparisons susceptible to different biases that may be combined as if from independent studies of different data by different investigators, despite using the same data twice. If the two factors concur, then they may exhibit greater insensitivity to unmeasured biases than either factor exhibits on its own. Replication and Evidence Factors in Observational Studies includes four parts: A concise introduction to causal inference, making the book self-contained Practical examples of evidence factors from the health and social sciences with analyses in R The theory of evidence factors Study design with evidence factors A companion R package evident is available from CRAN.