Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis


Book Description

This edited collection of 12 chapters by research workers from a wide range of disciplines resolves the confusion that currently surrounds the “hygiene hypothesis” by considering the human need for exposure to microorganisms from an evolutionary point of view. The book explains why we evolved a requirement for exposure to microbiota from our mothers, from other people, and from the natural environment. It also explains the physiological roles of these exposures, what goes wrong when the exposures are distorted and how human lifestyles and activities, including degradation of the natural environment, are leading to this distortion. Particular attention is given to the range of pathologies associated with inappropriate microbial exposures and inappropriate colonization, including immunoregulatory problems such as allergies and autoimmunity, metabolic problems such as obesity and diabetes, and problems of central nervous system function and neurodegeneration. This book is of profound relevance to most medical disciplines, but also to those concerned with preserving the natural environment and with developing healthier urbanisation.




Microorganisms and Mental Health


Book Description

This volume contains up-to-date contributions written by leading experts in the role played by various microorganisms in psychiatric and neurological illness. The initial chapters present an evolutionary framework for the impact of microorganisms on behavior. This is followed by historical and epidemiological perspectives of the role of viruses in psychiatric illness. Subsequent chapters focus on different classes of microorganisms and psychiatric illnesses and emphasize diverse research approaches ranging from preclinical models to therapeutic interventions.




Climate Change and Global Health


Book Description

There is increasing understanding that climate change will have profound, mostly harmful effects on human health. In this authoritative book, international experts examine long-recognized areas of health concern for populations vulnerable to climate change, describing effects that are both direct, such as heat waves, and indirect, such as via vector-borne diseases. This lively yet scholarly resource explores all these issues, finishing with a practical discussion of avenues to reform. As Mary Robinson, former UN High Commissioner for Human Rights, states in the foreword: 'Climate change interacts with many undesirable aspects of human behaviour, including inequality, racism and other manifestations of injustice. Climate change policies, as practised by most countries in the global North, not only interact with these long-standing forms of injustice, but exemplify a new form, of startling magnitude.' This book will be invaluable for students, post-graduates, researchers and policy-makers in public health, climate change and medicine.




Epidemiology and the People's Health


Book Description

"Theory. Traced to its Greek roots, "theory" means to see inwards; to theorize is to use our mind's eye systematically, following articulated principles, to discern meaningful patterns among observations and ideas (Oxford English Dictionary [OED] 2022). The implication is that without theory, observation is blind and explanation is impossible"--




Nutritional Impacts the Health and Physiology of the Avian Gastro-intestinal Tract


Book Description

The physiology of birds is regulated by the interplay internally between the gastrointestinal functioning, endocrine, nervous and defensive systems (immune and anti-oxidative). Acting on these are external factors such as nutrition and the gastrointestinal microbiome. One focus of this Research Topic is the importance of various nutritional physiological approaches, the parameters to be employed and an assessment of their reliability and feasibility. Aims of this topic include the following: 1) Identify specific interventions to facilitate the elimination of food borne pathogens in poultry 2) Develop nutritional strategies to reduce food borne colonization in poultry and reduce prevalence of food borne pathogens in poultry products Increasing numbers of poultry are raised without antibiotics. There is growing attention to using dietary supplements to replace antibiotics, to alter intestinal microbial populations, to stimulate antioxidative and immune systems and to improve overall intestinal health. This Research Topic will include a focus on determining the viability of nutritional intervention like probiotics and non-antibiotic growth promoters, alone or in combination, as a means to mitigate food borne contamination, particularly in the context of an antibiotic-free setting. Particular attention will be paid in determining the effects of dietary supplements on intestinal integrity, gene expression, antioxidative systems and pro-inflammatory cytokines. Reviews and research papers, among other article types, on all aspects of the interactions between nutrition, physiology and microbiology in birds, particularly poultry.




Parasite Diversity and Diversification


Book Description

By joining phylogenetics and evolutionary ecology, this book explores the patterns of parasite diversity while revealing diversification processes.




Systematics, Evolution, and Biogeography of Compositae


Book Description

"This spectacular book does full justice to the Compositae (Asteraceae), the largest and most successful flowering plant family with some 1700 genera and 24,000 species. It is an indispensable reference, providing the most up-to-date hypotheses of phylogenetic relationships in the family based on molecular and morphological characters, along with the corresponding subfamilial and tribal classification. The 2009 work not only integrates the extensive molecular phylogenetic analyses conducted in the last 25 years, but also uses these to produce a metatree for about 900 taxa of Compositae. The book contains 44 chapters, contributed by 80 authors, covering the history, economic importance, character variation, and systematic and phylogenetic diversity of the family. The emphasis of this work is phylogenetic; its chapters provide a detailed, current, and thoroughly documented presentation of the major (and not so major) clades in the family, citing some 2632 references. Like the Compositae, the book is massive, diverse, and fascinating. It is beautifully illustrated, with 170 figures, and an additional 108 cladograms (all consistently color-coded, based on the geographic range of the included taxa); within these figures are displayed 443 color photographs, clearly demonstrating the amazing array of floral and vegetative form expressed by members of the clade." --NHBS Environment Bookstore.




River Networks as Ecological Corridors


Book Description

A summary of state-of-the-art research on how the river environment impacts biodiversity, species invasions, population dynamics, and the spread of waterborne disease. Blending laboratory, field and theoretical studies, it is the go-to reference for graduate students and researchers in river ecology, hydrology, and epidemiology.




The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic


Book Description

In March and early April 2009, a new, swine-origin 2009-H1N1 influenza A virus emerged in Mexico and the United States. During the first few weeks of surveillance, the virus spread by human-to-human transmission worldwide to over 30 countries. On June 11, 2009, the World Health Organization (WHO) raised the worldwide pandemic alert level to Phase 6 in response to the ongoing global spread of the novel influenza A (H1N1) virus. By October 30, 2009, the H1N1 influenza A had spread to 191 countries and resulted in 5,700 fatalities. A national emergency was declared in the United States and the swine flu joined SARS and the avian flu as pandemics of the 21st century. Vaccination is currently available, but in limited supply, and with a 60 percent effectiveness rate against the virus. The story of how this new influenza virus spread out of Mexico to other parts of North America and then on to Europe, the Far East, and now Australia and the Pacific Rim countries has its origins in the global interconnectedness of travel, trade, and tourism. Given the rapid spread of the virus, the international scientific, public health, security, and policy communities had to mobilize quickly to characterize this unique virus and address its potential effects. The World Health Organization and Centers for Disease Control have played critical roles in the surveillance, detection and responses to the H1N1 virus. The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic: Global Challenges, Global Solutions aimed to examine the evolutionary origins of the H1N1 virus and evaluate its potential public health and socioeconomic consequences, while monitoring and mitigating the impact of a fast-moving pandemic. The rapporteurs for this workshop reported on the need for increased and geographically robust global influenza vaccine production capacities; enhanced and sustained interpandemic demand for seasonal influenza vaccines; clear "triggers" for pandemic alert levels; and accelerated research collaboration on new vaccine manufacturing techniques. This book will be an essential guide for healthcare professionals, policymakers, drug manufacturers and investigators.




Gene Drives on the Horizon


Book Description

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.