Molecular Biology of the Cell
Author :
Publisher :
Page : 0 pages
File Size : 45,72 MB
Release : 2002
Category : Cells
ISBN : 9780815332183
Protein Families
Author : Christine A. Orengo
Publisher : John Wiley & Sons
Page : 566 pages
File Size : 14,5 MB
Release : 2014-02-03
Category : Science
ISBN : 0470624221
Book Description
New insights into the evolution and nature of proteins Exploring several distinct approaches, this book describes the methods for comparing protein sequences and protein structures in order to identify homologous relationships and classify proteins and protein domains into evolutionary families. Readers will discover the common features as well as the key philosophical differences underlying the major protein classification systems, including Pfam, Panther, SCOP, and CATH. Moreover, they'll discover how these systems can be used to understand the evolution of protein families as well as understand and predict the degree to which structural and functional information are shared between relatives in a protein family. Edited and authored by leading international experts, Protein Families offers new insights into protein families that are important to medical research as well as protein families that help us understand biological systems and key biological processes such as cell signaling and the immune response. The book is divided into three sections: Section I: Concepts Underlying Protein Family Classification reviews the major strategies for identifying homologous proteins and classifying them into families. Section II: In-Depth Reviews of Protein Families focuses on some fascinating super protein families for which we have substantial amounts of sequence, structural and functional data, making it possible to trace the emergence of functionally diverse relatives. Section III: Review of Protein Families in Important Biological Systems examines protein families associated with a particular biological theme, such as the cytoskeleton. All chapters are extensively illustrated, including depictions of evolutionary relationships. References at the end of each chapter guide readers to original research papers and reviews in the field. Covering protein family classification systems alongside detailed descriptions of select protein families, this book offers biochemists, molecular biologists, protein scientists, structural biologists, and bioinformaticians new insight into the evolution and nature of proteins.
Supramolecular Structure and Function
Author : Greta Pifat-Mrzljak
Publisher : Springer Science & Business Media
Page : 197 pages
File Size : 38,65 MB
Release : 2013-03-12
Category : Science
ISBN : 3642709052
Book Description
During the past decade we have witnessed not only an increase in knowledge of the "traditional" biophysical problems, but also an understanding of the molecular basis of various biological phenomena. The principles and methods of biophysics now provide an underpin ning of all of the basic biosciences and are the rational language for discussion between scientists of different disciplines. The International School on Biophysics Supramolecular Structure and Function held in Dubrovnik in September 1984 had as its goal to provide comprehensive discussions on a large number of subjects both for younger scientists at the doctoral or postdoctoral level interested in the molecular nature of fundamental biological entities, and for experienced scientists wishing to gain a broader insight into molecular structures and functions. The topics discussed at the School were inter- and intramolecular interactions in biological systems, and the structure, organization, and function of biological macromolecules and supramolecular assemblies. A number of topics were centered around either a biological problem or a physical technique, sometimes giving an unbalanced view of the field under discussion. Some of the topics required previous knowledge of basic biophysical principles, which were then applied to gain greater insight into the molecular functions of diverse supramolecular systems. Although not all the lectures could be prepared for publication in this volume, I hope that it contains valuable up-to-date information on various aspects of the molecular basis of life.
Algorithms on Strings, Trees, and Sequences
Author : Dan Gusfield
Publisher : Cambridge University Press
Page : 556 pages
File Size : 41,47 MB
Release : 1997-05-28
Category : Computers
ISBN : 1139811002
Book Description
String algorithms are a traditional area of study in computer science. In recent years their importance has grown dramatically with the huge increase of electronically stored text and of molecular sequence data (DNA or protein sequences) produced by various genome projects. This book is a general text on computer algorithms for string processing. In addition to pure computer science, the book contains extensive discussions on biological problems that are cast as string problems, and on methods developed to solve them. It emphasises the fundamental ideas and techniques central to today's applications. New approaches to this complex material simplify methods that up to now have been for the specialist alone. With over 400 exercises to reinforce the material and develop additional topics, the book is suitable as a text for graduate or advanced undergraduate students in computer science, computational biology, or bio-informatics. Its discussion of current algorithms and techniques also makes it a reference for professionals.
From Protein Structure to Function with Bioinformatics
Author : Daniel John Rigden
Publisher : Springer Science & Business Media
Page : 330 pages
File Size : 17,83 MB
Release : 2008-12-11
Category : Science
ISBN : 1402090587
Book Description
Proteins lie at the heart of almost all biological processes and have an incredibly wide range of activities. Central to the function of all proteins is their ability to adopt, stably or sometimes transiently, structures that allow for interaction with other molecules. An understanding of the structure of a protein can therefore lead us to a much improved picture of its molecular function. This realisation has been a prime motivation of recent Structural Genomics projects, involving large-scale experimental determination of protein structures, often those of proteins about which little is known of function. These initiatives have, in turn, stimulated the massive development of novel methods for prediction of protein function from structure. Since model structures may also take advantage of new function prediction algorithms, the first part of the book deals with the various ways in which protein structures may be predicted or inferred, including specific treatment of membrane and intrinsically disordered proteins. A detailed consideration of current structure-based function prediction methodologies forms the second part of this book, which concludes with two chapters, focusing specifically on case studies, designed to illustrate the real-world application of these methods. With bang up-to-date texts from world experts, and abundant links to publicly available resources, this book will be invaluable to anyone who studies proteins and the endlessly fascinating relationship between their structure and function.
Molecular Modeling and Simulation
Author : Tamar Schlick
Publisher : Springer Science & Business Media
Page : 669 pages
File Size : 37,92 MB
Release : 2013-04-18
Category : Science
ISBN : 0387224645
Book Description
Very broad overview of the field intended for an interdisciplinary audience; Lively discussion of current challenges written in a colloquial style; Author is a rising star in this discipline; Suitably accessible for beginners and suitably rigorous for experts; Features extensive four-color illustrations; Appendices featuring homework assignments and reading lists complement the material in the main text
Practical Protein Bioinformatics
Author : Florencio Pazos
Publisher : Springer
Page : 111 pages
File Size : 14,5 MB
Release : 2014-11-28
Category : Science
ISBN : 3319127276
Book Description
This book describes more than 60 web-accessible computational tools for protein analysis and is totally practical, with detailed explanations on how to use these tools and interpret their results and minimal mentions to their theoretical basis (only when that is required for making a better use of them). It covers a wide range of tools for dealing with different aspects of proteins, from their sequences, to their three-dimensional structures, and the biological networks they are immersed in. The selection of tools is based on the experience of the authors that lead a protein bioinformatics facility in a large research centre, with the additional constraint that the tools should be accessible through standard web browsers without requiring the local installation of specific software, command-line tools, etc. The web tools covered include those aimed to retrieve protein information, look for similar proteins, generate pair-wise and multiple sequence alignments of protein sequences, work with protein domains and motifs, study the phylogeny of a family of proteins, retrieve, manipulate and visualize protein three-dimensional structures, predict protein structural features as well as whole three-dimensional structures, extract biological information from protein structures, summarize large protein sets, study protein interaction and metabolic networks, etc. The book is associated to a dynamic web site that will reflect changes in the web addresses of the tools, updates of these, etc. It also contains QR codes that can be scanned with any device to direct its browser to the tool web site. This monograph will be most valuable for researchers in experimental labs without specific knowledge on bioinformatics or computing.
Protein-protein Complexes
Author : Martin Zacharias
Publisher : World Scientific
Page : 401 pages
File Size : 35,7 MB
Release : 2010
Category : Science
ISBN : 1848163398
Book Description
Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.
Proteins
Author : David Whitford
Publisher : John Wiley & Sons
Page : 544 pages
File Size : 20,73 MB
Release : 2013-04-25
Category : Science
ISBN : 1118685725
Book Description
Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability. The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins. An invaluable resource for students of Biochemistry, Molecular Biology, Medicine and Chemistry providing a modern approach to the subject of Proteins.
Protein Engineering Handbook
Author : Stefan Lutz
Publisher : John Wiley & Sons
Page : 1021 pages
File Size : 38,86 MB
Release : 2012-07-31
Category : Science
ISBN : 3527667016
Book Description
Unparalleled in size and scope, this new major reference integrates academic and industrial knowledge into a single resource, allowing for a unique overview of the entire field. Adopting a systematic and practice-oriented approach, and including a wide range of technical and methodological information, this highly accessible handbook is an invaluable 'toolbox' for any bioengineer. In two massive volumes, it covers the full spectrum of current concepts, methods and application areas.
