Experimental Pharmacology as a Basis for Therapeutics
Author : Hans Horst Meyer
Publisher :
Page : 676 pages
File Size : 12,96 MB
Release : 1926
Category : Dummies (Bookselling)
ISBN :
Drugs on Trial
Author : Andreas-Holger Maehle
Publisher : Rodopi
Page : 388 pages
File Size : 23,41 MB
Release : 1999
Category : Medical
ISBN : 9789042007932
Book Description
This book describes the main issues of eighteenth-century pharmacology and therapeutics and provides detailed case studies of three key areas: lithontriptics (remedies against urinary stones), opium, and Peruvian bark (quinine).
Concepts and Principles of Pharmacology
Author : James E. Barrett
Publisher : Springer Nature
Page : 457 pages
File Size : 10,9 MB
Release : 2019-12-24
Category : Medical
ISBN : 3030353621
Book Description
Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
A Pharmacology Primer
Author : Terry P. Kenakin
Publisher : Academic Press
Page : 489 pages
File Size : 29,47 MB
Release : 2018-10-26
Category : Medical
ISBN : 0128139587
Book Description
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research. - Highlights changes surrounding strategies for drug discovery, providing a comprehensive reference and featuring advances in the methods involved - Includes multiple new sections, such as development and utilization of models in pharmacology, de-orphanization of new drug targets, predicting impact of disease on drug pharmacokinetics, and the impact of enzyme kinetics on drug-drug interactions - Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data
Pharmacology and Therapeutics
Author : Scott A. Waldman
Publisher : Saunders
Page : 0 pages
File Size : 45,87 MB
Release : 2009
Category : Chemotherapy
ISBN : 9781416060987
Book Description
Everything you need to know about all of today's drugs in a coherent, easy-to-use format - from the underlying science through innovation, translation, regulation, and clinical implementation. This multimedia resource fills a critical need for a more clinically focused, user-friendly pharmacology reference. Evidence-based therapeutic guidelines facilitate decision making; and coverage of pharmacogenetics and pharmacogenomics, regenerative pharmacology, stem cell therapies, and the emerging field of individualized medicine keeps you at the forefront of the latest developments.
Stereochemical Aspects of Drug Action and Disposition
Author : Michel F. Eichelbaum
Publisher : Springer Science & Business Media
Page : 455 pages
File Size : 31,93 MB
Release : 2012-12-06
Category : Medical
ISBN : 3642558429
Book Description
This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first section on chemical aspects contains chapters on chemical synthesis, analysis, natural products, chiral stability (racemezation) and physical properties. The second section is on experimental pharmacology, with chapters on drug-receptor interactions, chiral recognition, ion channels, and molecular toxicology. The third section focuses on drug disposition, with chapters on absorption, distribution, protein binding, metabolism and elimination. The final section is dedicated to regulatory and clinical aspects.
General and Molecular Pharmacology
Author : Francesco Clementi
Publisher : John Wiley & Sons
Page : 784 pages
File Size : 13,53 MB
Release : 2015-07-01
Category : Medical
ISBN : 1118768590
Book Description
With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book
Basic and Clinical Pharmacology
Author : Bertram G. Katzung
Publisher :
Page : 1217 pages
File Size : 12,82 MB
Release : 2001
Category : Clinical pharmacology
ISBN : 9780071179683
Book Description
This best selling book delivers the most current, complete, and authoritative pharmacology information to students and practitioners. All sections are updated with new drug information and references. New! Many new figures and diagrams, along with boxes of highlighted material explaining the "how and why" behind the facts.
Antisense Research and Application
Author : Stanley T. Crooke
Publisher : Springer Science & Business Media
Page : 646 pages
File Size : 22,78 MB
Release : 2012-12-06
Category : Medical
ISBN : 3642587852
Book Description
Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.
cGMP: Generators, Effectors and Therapeutic Implications
Author : Harald H. H. W. Schmidt
Publisher : Springer Science & Business Media
Page : 581 pages
File Size : 35,32 MB
Release : 2008-12-17
Category : Science
ISBN : 3540689648
Book Description
After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.
