Fiat Flux


Book Description

Wilson R. Bachelor was a Tennessee native who moved with his family to Franklin County, Arkansas, in 1870. A country doctor and natural philosopher, Bachelor was impelled to chronicle his life from 1870 to 1902, documenting the family's move to Arkansas, their settling a farm in Franklin County, and Bachelor's medical practice. Bachelor was an avid reader with wide-ranging interests in literature, science, nature, politics, and religion, and he became a self-professed freethinker in the 1870s. He was driven by a concept he called "fiat flux," an awareness of the "rapid flight of time" that motivated him to treat the people around him and the world itself as precious and fleeting. He wrote occasional pieces for a local newspaper, bringing his unusually enlightened perspectives to the subjects of women's rights, capital punishment, the role of religion in politics, and the domination of the American political system by economic elite in the 1890s. These essays, along with family letters and the original diary entries, are included here for an uncommon glimpse into the life of a country doctor in nineteenth-century Arkansas.




Plant Metabolic Networks


Book Description

Plants are the basis for human nutrition and of increasing interest for the chemical industry as a source of chemical feed stocks. Fuels derived from plant biomass will increasingly replace fossil fuels in the future. In order to increase crop productivity, design new plant products, and create new energy crops, there is need for methods of qualitative and quantitative analysis of metabolism which are able to guide the rational re-design of metabolic networks. In this book, recent advances in qualitative and quantitative analysis of metabolism are summarized to give an overview of the current state of knowledge. Principles of the analysis of network structure, flux analysis, and kinetic modeling are described. Analytical methods necessary to produce the data needed for metabolic flux analysis and for kinetic modeling are described. The analysis of larger metabolic networks is only possible by using computer assistance. Therefore each chapter of the book shall also describe software available for this purpose.




User-Level Workflow Design


Book Description

The continuous trend in computer science to lift programming to higher abstraction levels increases scalability and opens programming to a wider public. In particular, service-oriented programming and the support of semantics-based frameworks make application development accessible to users with almost no programming expertise. This monograph establishes requirement-centric scientific workflow design as an instance of consequent constraint-driven development. Requirements formulated in terms of user-level constraints are automatically transformed into running applications using temporal logic-based synthesis technology. The impact of this approach is illustrated by applying it to four very different bioinformatics scenarios: phylogenetic analysis, the dedicated GeneFisher-P scenario, the FiatFlux-P scenario, and microarray data analyses.




Out of Sorts


Book Description

The new history of the book has constituted a vibrant academic field in recent years, and theories of print culture have moved to the center of much scholarly discourse. One might think typography would be a basic element in the construction of these theories, yet if only we would pay careful attention to detail, Joseph A. Dane argues, we would find something else entirely: that a careful consideration of typography serves not as a material support to prevailing theories of print but, rather, as a recalcitrant counter-voice to them. In Out of Sorts Dane continues his examination of the ways in which the grand narratives of book history mask what we might actually learn by looking at books themselves. He considers the differences between internal and external evidence for the nature of the type used by Gutenberg and the curious disconnection between the two, and he explores how descriptions of typesetting devices from the seventeenth and eighteenth centuries have been projected back onto the fifteenth to make the earlier period not more accessible but less. In subsequent chapters, he considers topics that include the modern mythologies of so-called gothic typefaces, the presence of nontypographical elements in typographical form, and the assumptions that underlie the electronic editions of a medieval poem or the visual representation of typographical history in nineteenth-century studies of the subject. Is Dane one of the most original or most traditional of historians of print? In Out of Sorts he demonstrates that it may well be possible to be both things at once.




Machine Learning and IoT


Book Description

This book discusses some of the innumerable ways in which computational methods can be used to facilitate research in biology and medicine - from storing enormous amounts of biological data to solving complex biological problems and enhancing treatment of various grave diseases.




Metabolomics


Book Description

Metabolomics: Methods and Protocols examines the state-of-the-art in metabolomic analysis. Leading researchers in the field present protocols for the application of complementary analytical methods, such as gas chromatography-mass spectrometry (GC-MS). Metabolomics: Methods and Protocols contains forward-looking protocols, which provide the essential groundwork for future efforts in elucidating the structure of the unknowns detected in metabolomic studies.




A Family Practice


Book Description

A Family Practice is the sweeping saga of four generations of doctors, Russell men seeking innovative ways to sustain themselves as medical practitioners in the American South from the early nineteenth to the latter half of the twentieth century. The thread that binds the stories in this saga is one of blood, of medical vocations passed from fathers to sons and nephews. This study of four generations of Russell doctors is an historical study with a biographical thread running through it. The authors take a wide-ranging look at the meaning of intergenerational vocations and the role of family, the economy, and social issues on the evolution of medical education and practice in the United States.




Making Climate Lawyers


Book Description

Why did it take so long for American law schools to start teaching about climate change? Although most environmental law professors were aware of climate change by 1990, it took nearly fifteen years for them to incorporate the topic into their curriculum. In her innovative new work, Kimberly K. Smith explores how American environmental law professors have addressed climate change, identifying the barriers they faced, how they overcame them, and how they created “climate law” as a domain of legal specialization. Making Climate Lawyers explores the history of why American law schools were resistant to teaching about climate change and how that changed over the course of a forty-year period, resulting in law schools across the country incorporating climate change into their curricula, with many even establishing centers on the environment. Smith challenges dominant explanations of why the United States was slow to develop climate policy: it wasn’t just political opposition or short-sightedness. Creating climate legal professionals required changing the fundamentals of legal education. Based on dozens of interviews with faculty and students, Making Climate Lawyers fills a gap in the literature on the intellectual history of climate change, most of which focuses on the history of climate science. Smith focuses instead on how the climate problem fits (or doesn’t fit) into the structure of American law. She uses this story as a lens through which to understand both the transformation of legal education since the 1980s and the nature of climate change as a policy problem.




The Editorial Gaze


Book Description

This collection of original essays brings international and multidisciplinary perspectives to the problem of how to understand and practice editorial mediation: How does editing alter what it seeks to represent? How does it condition the relationship between texts and readers? The different concerns shared by editors of a variety of genres, literary and otherwise, emerge here as constructive new approaches to the theory and practice of editing are explored. The essays make a concerted attempt to assess the implications of postmodern thought on one of the oldest and most fundamental cultural activities, editing The section on theory covers such important subjects as editorial responsibility, the death of the author, and the nature of the authorial voice. The practice section covers actual editing situations in various literary areas and in musicology, recorded music, and the preservation of oral literature. The multidisciplinary volume will find its readers among students of textual criticism, literature, music, and folklore as well as any readers of postmodern criticism.




Making Shakespeare


Book Description

Making Shakespeare is a lively introduction to the major issues of the stage and print history, whilst also raising questions about what a Shakespeare play actually is. Tiffany Stern reveals how London, the theatre, the actors and the way in which the plays were written and printed all affect the 'Shakespeare' that we now read. Concentrating on the instability and fluidity of Shakespeare's texts, her book discusses what happened to a manuscript between its first composition, its performance on stage and its printing, and identifies traces of the production system in the plays we read. She argues that the versions of Shakespeare that have come down to us have inevitably been formed by the contexts from which they emerged; being shaped by, for example, the way actors received and responded to their lines, the props and music used in the theatre, or the continual revision of plays by the playhouses and printers. Allowing a fuller understanding of the texts we read and perform, Making Shakespeare is the perfect introduction to issues of stage and page. A refreshingly clear, accessible read, this book will allow even those with no expert knowledge to begin to contextualize Shakespeare's plays for themselves, in ways both old and new.