Thrombolysis in Pulmonary Embolism


Book Description

This book provides an up-to-date review of the use of thrombolytic therapy in the treatment of acute pulmonary embolism. It discusses the mechanisms of thrombosis; pharmacokinetics and pharmacodynamics of the most commonly used fibrinolytics; evidence-based results from multicenter control trials in which thrombolytic treatment was administered; criteria by which pulmonary embolism patients requiring thrombolysis are identified; and the use of thrombolytic therapy in special situations such as in in-transit thrombus and pregnancy. Focusing on peripheral intravenous thrombolysis, which can performed safely and effectively in emergency departments, hospital wards, and intensive critical care units in tertiary and community hospitals, Thrombolysis in Pulmonary Embolism is a valuable resource for cardiologists, pulmonologists, and internists.




Acute Pulmonary Embolism


Book Description

The value of echocardiography in the diagnostic work-up of patients with suspected acute pulmonary embolism.- New developments in the thrombolytic therapy of venous thrombosis.- Mechanism of blood coagulation. Newer aspects of anticoagulant and antithrombotic therapy.MR-angiography in the diagnosis of pulmonary embolism.Scintigraphy-ventilation/perfusion scanning and imaging of the embolus.- Clinical course and prognosis of acute pulmonary embolism.- The molecular mechanisms of inherited thombophilia.




Primary Angioplasty


Book Description

This book is open access under a CC BY 4.0 license. This quick-reference handbook offers a concise and practical review of key aspects of the treatment of ST-segment elevation myocardial infarction (STEMI) in the era of primary percutaneous coronary intervention (PPCI). In the context of STEMI, PPCI is the preferred mode of emergency revascularization. Access to PPCI is rapidly increasing and is now routinely practiced in both general and specialist hospitals and there has been a recent emphasis on developing STEMI networks to enhance and expedite the referral pathway. This coupled with concurrent developments to enhance the safety and efficacy of the PPCI procedure has heralded an era where STEMI interventions are increasingly considered an important subspecialty within interventional cardiology. Written by leading cardiologists who have been instrumental in the adoption of PPCI in their respective institutions, the book provides junior and senior cardiologists alike with insightful and thought-provoking tips and tricks to enhance the success of PPCI procedures, which may in turn translate into direct improvements in outcomes. The book is also relevant for healthcare providers and emergency department physicians.




Hemostasis and Thrombosis


Book Description

Hemostasis and Thrombosis: Practical Guidelines in Clinical Management Edited by Hussain I Saba MD, PhD Professor of Medicine Director of Hematology/Hemophilia/Hemostasis & Thrombosis Center USF College of Medicine Professor Emeritus Department of Malignant Hematology Moffitt Cancer Center and Research Institute Tampa, FL, USA Harold R Roberts MD Emeritus Professor of Medicine and Pathology Division of Hematology / Oncology University of North Carolina Chapel Hill, NC, USA Hemostasis and thrombosis is a hugely important, changing and complex area that impacts many other medical specialties, affecting at least 10 million people in the United States alone. It is vital for physicians to recognize abnormalities of hemostasis and thrombosis and to be able to address these problems in their patients. Hemostasis and Thrombosis: Practical Guidelines in Clinical Managementcovers all aspects of the practical management of commonly encountered thrombotic and bleeding disorders, with emphasis on clinical diagnosis, treatment, and day-to-day management. The most clinically relevant material from the literature has been carefully compiled, along with: - Discussions of new and upcoming diagnostic and therapeutic modalities - Practical clinical advice for all those dealing with coagulation, hemostasis and thrombosis Written by world leading specialists contributing their expertise in succinct text and focusing on the latest clinical guidance, Hemostasis and Thrombosis: Practical Guidelines in Clinical Management will benefit hematologists in training and in practice working in the fields of coagulation, hemostasis and thrombosis. Titles of related interest Practical Hemostasis and Thrombosis, 2nd Edition Key, ISBN 9781405184601 Hemophilia and Hemostasis: A Case-Based Approach to Management, 2nd Edition Ma, ISBN 9780470659762 Quality in Laboratory Hemostasis and Thrombosis, 2nd Edition Kitchen, ISBN 9780470671191 www.wiley.com/go/hematology




Anesthetic Pharmacology


Book Description

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.




Critical Heart Disease in Infants and Children E-Book


Book Description

**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Pediatric Surgery** Now in brilliant full color and reflecting recent significant changes in the field, Critical Heart Disease in Infants and Children, 3rd Edition, keeps you abreast of the skills and knowledge required to safely care for children with congenital and acquired heart disease in the ICU. Pediatric intensivists, cardiologists, cardiac surgeons, and anesthesiologists from leading centers around the world provide a well-rounded perspective on basic scientific principles, medical and pharmacologic treatments, surgical techniques, and equipment. - Features comprehensive updates throughout the text, including indications, techniques, potential complications in perioperative management of patients, and surgical techniques for congenital heart disease. - Covers recent advances in the treatment of pulmonary hypertension, developments in mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization. - Features an all-new, full-color format that speeds navigation and helps clarify complex concepts. - Contains 27 new chapters with an emphasis on the team approach to patient care in the ICU including creating multidisciplinary teams, quality and performance improvement, training , and challenges and solutions to developing a cohesive team environment. - Includes a detailed chapter on bedside ultrasound, walking you through the techniques you're most likely to encounter in the ICU. - Employs well-documented tables, text boxes, and algorithms to make clinical information easy to access, and more than two dozen video clips provide a more complete understanding of echocardiography, imaging modalities, pulmonary hypertension, and more. - Describes the basic pharmacology and clinical applications of new pharmacologic agents. - Examines issues affecting adults with congenital heart disease. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. - Offers four completely new chapters: Cardiac Trauma, Congenital Heart Disease in the Adult, Congenitally Corrected Transposition of the Great Arteries, and Outcome Evaluation. - Describes the basic pharmacology and clinical applications of all of the new pharmacologic agents. - Details important refinements and developments in surgical techniques, including the Ross pulmonary autograft replacement of the aortic valve, video-assisted fluoroscopy, and the extracardiac Fontan connection, and discusses their indications and potential complications. - Explores the latest advances in the treatment of pulmonary hypertension, new developments in mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization. - Examines issues affecting adults with congenital heart disease.




Trauma Induced Coagulopathy


Book Description

The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.




Therapeutic Enzymes: Function and Clinical Implications


Book Description

Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.




Neurocritical Care Pharmacotherapy


Book Description

Neurocritical Care Pharmacotherapy: A Clinican's Guide is a practical, succinct but comprehensive pharmacy handbook provides up-to-date clinical guidance on the effective selection, prescription, and usage of neurocritical care drugs for patients with acute neurologic illnesses. The treatment of the critically ill neurologic patient is often difficult, specialized, and includes drugs infrequently used in other intensive care units such as antiepileptic drugs, osmotic agents or acute immunotherapy such as intravenous immunoglobulin and plasma exchange. This text discusses choosing the right combination of drugs; how to correctly prescribe and administer the drugs; how to monitor drug efficacy and side effects; how neurocritical care drugs interact with other medications; and comprehensive coverage of current treatment options. Key Feature of this Manual Include - A brief discussion of the basic pharmacology of each neurocritical drug, with an emphasis on how to select and use these drugs in multiple clinical contexts. - 150 drugs accompanied by a diagram for quick comprehension and drug administration guides. - Unique blending of expertise of neurointensivist with a critical care pharmacist to provide a vital resource for both specialities - References for further reading that are oriented toward utility in clinical practice.




Coronary Microvascular Obstruction in Acute Myocardial Infarction


Book Description

Coronary Microvascular Obstruction in Acute Myocardial Infarction: From Mechanisms to Treatment provides a comprehensive understanding of the phenomenon of coronary microvascular obstruction (CMVO) that is the main limitation of reperfusion therapies in ST-elevation myocardial infarction. It provides in-depth coverage of the phenomenon of CMVO which heavily affects prognosis by increasing the risk of death and heart failure at follow-up. A first of its kind reference dedicated solely to this topic, it is appropriate for a wide audience, from researchers, to those who aid in the management, prevention and treatment of CMVO. - Provides in-depth coverage of coronary microvascular obstruction (CMVO), spanning research, management, prevention and treatment - Includes the most up-to-date information on CMVO as presented from top experts around the word - Provides access to a companion website with extra material, including tables, additional references and instructional videos - Gives extensive coverage on how to measure CMVO, including in-depth indexes that can be used to detect and quantify the phenomenon