First Hitting Time Regression Models


Book Description

This book aims to promote regression methods for analyzing lifetime (or time-to-event) data that are based on a representation of the underlying process, and are therefore likely to offer greater scientific insight compared to purely empirical methods. In contrast to the rich statistical literature, the regression methods actually employed in lifetime data analysis are limited, particularly in the biomedical field where D. R. Cox’s famous semi-parametric proportional hazards model predominates. Practitioners should become familiar with more flexible models. The first hitting time regression models (or threshold regression) presented here represent observed events as the outcome of an underlying stochastic process. One example is death occurring when the patient’s health status falls to zero, but the idea has wide applicability – in biology, engineering, banking and finance, and elsewhere. The central topic is the model based on an underlying Wiener process, leading to lifetimes following the inverse Gaussian distribution. Introducing time-varying covariates and many other extensions are considered. Various applications are presented in detail.




Theory and Practice of Risk Assessment


Book Description

This book covers the latest results in the field of risk analysis. Presented topics include probabilistic models in cancer research, models and methods in longevity, epidemiology of cancer risk, engineering reliability and economical risk problems. The contributions of this volume originate from the 5th International Conference on Risk Analysis (ICRA 5). The conference brought together researchers and practitioners working in the field of risk analysis in order to present new theoretical and computational methods with applications in biology, environmental sciences, public health, economics and finance.




Demography of Population Health, Aging and Health Expenditures


Book Description

This book provides theoretical and applied material for estimating vital parts of demography and health issues including the healthy aging process along with calculating the healthy life years lost to disability. It further includes the appropriate methodology for the optimum health expenditure allocation. Through providing data analysis, statistical and stochastic methodology, probability approach and important applications, the book explores topics such as aging and mortality, birth-death processes, self-perceived age, life-time and survival as well as pension and labor-force. By providing a methodological approach to health problems in demography and society including and quantifying important parameters, this book is a valuable guide for researchers, theoreticians and practitioners from various disciplines.




Mathematical and Statistical Models and Methods in Reliability


Book Description

The book is a selection of invited chapters, all of which deal with various aspects of mathematical and statistical models and methods in reliability. Written by renowned experts in the field of reliability, the contributions cover a wide range of applications, reflecting recent developments in areas such as survival analysis, aging, lifetime data analysis, artificial intelligence, medicine, carcinogenesis studies, nuclear power, financial modeling, aircraft engineering, quality control, and transportation. Mathematical and Statistical Models and Methods in Reliability is an excellent reference text for researchers and practitioners in applied probability and statistics, industrial statistics, engineering, medicine, finance, transportation, the oil and gas industry, and artificial intelligence.




First Hitting Time Regression Models


Book Description

This book aims to promote regression methods for analyzing lifetime (or time-to-event) data that are based on a representation of the underlying process, and are therefore likely to offer greater scientific insight compared to purely empirical methods. In contrast to the rich statistical literature, the regression methods actually employed in lifetime data analysis are limited, particularly in the biomedical field where D. R. Cox’s famous semi-parametric proportional hazards model predominates. Practitioners should become familiar with more flexible models. The first hitting time regression models (or threshold regression) presented here represent observed events as the outcome of an underlying stochastic process. One example is death occurring when the patient’s health status falls to zero, but the idea has wide applicability – in biology, engineering, banking and finance, and elsewhere. The central topic is the model based on an underlying Wiener process, leading to lifetimes following the inverse Gaussian distribution. Introducing time-varying covariates and many other extensions are considered. Various applications are presented in detail.




Encyclopedia of Quantitative Risk Analysis and Assessment


Book Description

Leading the way in this field, the Encyclopedia of Quantitative Risk Analysis and Assessment is the first publication to offer a modern, comprehensive and in-depth resource to the huge variety of disciplines involved. A truly international work, its coverage ranges across risk issues pertinent to life scientists, engineers, policy makers, healthcare professionals, the finance industry, the military and practising statisticians. Drawing on the expertise of world-renowned authors and editors in this field this title provides up-to-date material on drug safety, investment theory, public policy applications, transportation safety, public perception of risk, epidemiological risk, national defence and security, critical infrastructure, and program management. This major publication is easily accessible for all those involved in the field of risk assessment and analysis. For ease-of-use it is available in print and online.










Probability and Bayesian Modeling


Book Description

Probability and Bayesian Modeling is an introduction to probability and Bayesian thinking for undergraduate students with a calculus background. The first part of the book provides a broad view of probability including foundations, conditional probability, discrete and continuous distributions, and joint distributions. Statistical inference is presented completely from a Bayesian perspective. The text introduces inference and prediction for a single proportion and a single mean from Normal sampling. After fundamentals of Markov Chain Monte Carlo algorithms are introduced, Bayesian inference is described for hierarchical and regression models including logistic regression. The book presents several case studies motivated by some historical Bayesian studies and the authors’ research. This text reflects modern Bayesian statistical practice. Simulation is introduced in all the probability chapters and extensively used in the Bayesian material to simulate from the posterior and predictive distributions. One chapter describes the basic tenets of Metropolis and Gibbs sampling algorithms; however several chapters introduce the fundamentals of Bayesian inference for conjugate priors to deepen understanding. Strategies for constructing prior distributions are described in situations when one has substantial prior information and for cases where one has weak prior knowledge. One chapter introduces hierarchical Bayesian modeling as a practical way of combining data from different groups. There is an extensive discussion of Bayesian regression models including the construction of informative priors, inference about functions of the parameters of interest, prediction, and model selection. The text uses JAGS (Just Another Gibbs Sampler) as a general-purpose computational method for simulating from posterior distributions for a variety of Bayesian models. An R package ProbBayes is available containing all of the book datasets and special functions for illustrating concepts from the book. A complete solutions manual is available for instructors who adopt the book in the Additional Resources section.




An Introduction to Stochastic Modeling


Book Description

An Introduction to Stochastic Modeling provides information pertinent to the standard concepts and methods of stochastic modeling. This book presents the rich diversity of applications of stochastic processes in the sciences. Organized into nine chapters, this book begins with an overview of diverse types of stochastic models, which predicts a set of possible outcomes weighed by their likelihoods or probabilities. This text then provides exercises in the applications of simple stochastic analysis to appropriate problems. Other chapters consider the study of general functions of independent, identically distributed, nonnegative random variables representing the successive intervals between renewals. This book discusses as well the numerous examples of Markov branching processes that arise naturally in various scientific disciplines. The final chapter deals with queueing models, which aid the design process by predicting system performance. This book is a valuable resource for students of engineering and management science. Engineers will also find this book useful.