Functional Genomics in the Mouse
Author :
Publisher :
Page : 146 pages
File Size : 29,84 MB
Release : 1997
Category : Mice
ISBN :
Author :
Publisher :
Page : 146 pages
File Size : 29,84 MB
Release : 1997
Category : Mice
ISBN :
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
Page : 201 pages
File Size : 34,67 MB
Release : 2020-12-18
Category : Science
ISBN : 0309676738
One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.
Author : Silvia Garagna
Publisher :
Page : 336 pages
File Size : 19,36 MB
Release : 2004
Category : Cytogenetics
ISBN :
Author : Weisheng Victor Chen
Publisher :
Page : 388 pages
File Size : 44,89 MB
Release : 2004
Category : Genomes
ISBN :
Author : Can Ince
Publisher : Springer Science & Business Media
Page : 555 pages
File Size : 10,34 MB
Release : 2012-12-06
Category : Medical
ISBN : 146150483X
The physiological genomics of the cardiovascular system studies the relationship between gene and physiological (dys)function. It is a rapidly developing area of research and distinguishes itself from other areas of molecular medicine by its highly integrative nature. In this multi disciplinarian area of the physiological sciences, there is interaction between gene structure and physiological cardiovascular function as well as interactions between the different organs and their physiological compartments. The mouse has played a central role in the study of genomics due to the detailed knowledge of the mouse genome and the wide availability of genetically modified mice. In the past, the mouse had mainly been used in the area of immunology and molecular biology, and physiological interest in the mouse was scarce. As more insight has come into the structural genomics of the mouse, however, it has become increasingly important to understand the relation between gene and physiological function. With this in mind we have been organizing the Amsterdam Mouse Symposia to bring together different disciplines interested in the molecular basis of cardiovascular function (see J. of Clinical and Exp. Pharmacology and rd Physiology (2002) 29:A69-AI02 for the proceedings of the 3 Amsterdam Mouse Symposium and Basic Research in Cardiology (2000) 95:492-535 for nd the proceedings of the 2 symposium).
Author : Jean Louis Guénet
Publisher : Springer
Page : 417 pages
File Size : 20,13 MB
Release : 2014-11-29
Category : Science
ISBN : 3662442876
This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.
Author : Moshe Pritsker
Publisher :
Page : 218 pages
File Size : 44,12 MB
Release : 2005
Category :
ISBN :
Author : Paul M. Wassarman
Publisher : Academic Press
Page : 580 pages
File Size : 34,7 MB
Release : 2010
Category : Medical
ISBN : 9780123848826
17 years have passed since the first edition of the Guide to Techniques in Mouse Development (volume 225) was published. During this time development of technology used to investigate mouse development has not stood still, with enormous advances occuring in genomics, transgenic and ES cell methodology, and reprogramming, culminating with development of iPS cells. At both the cellular and molecular levels, a great many technological advances have been made that permit investigators to probe ever more deeply into all aspects of mouse development. This completely new version of the Guide has been split into two parts, both highlighting the techonological advances used to study mouse development.
Author :
Publisher :
Page : pages
File Size : 10,42 MB
Release : 2009
Category :
ISBN :
Mammalian genes have multiple functions in time and space during embryogenesis, aging, and in health and disease. This phenomenon of pleiotropic gene function is a major factor contributing to the increase of complexity from the mere number of approximately 25.000 protein-coding genes in the mammalian genome to the level of the organism. When and where a gene is expressed is an integral part of gene function. The profiling of gene expression and the study of gene regulation are therefore intriguing scientific objects of current biology. For a systems level approach to measure changes in transcript profiles in mouse models for human diseases we used microarray technologies and analysed transcriptome data from more than 1.100 DNA-chip experiments and 46 mutant mouse lines. Novel gene functions were revealed through the integration of multiple level data, including transcriptome, proteome, and metabolome in several mouse models.
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
Page : 201 pages
File Size : 43,36 MB
Release : 2020-11-18
Category : Science
ISBN : 0309676762
One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.