Future T/Issues


Book Description

Transplant practices are discussed in the medical realm, in fictional texts and in popular advertisement. Yet how do these sectors intersect and influence each other? How can the accounts of surgeons invested in transplant practice be brought into conversation with fictional voices? Future T/Issues positions transplantation at the intersection of natural science and the humanities and adds to the discussion of organ transplantation by focusing on one specific aspect that is commonly overlooked: the idea of speculation. By engaging with speculative fiction in conversation with life writing, it contributes to a more thorough understanding of transplantation as a cultural practice, showcasing that transplantation is imagined as part of the future both within and beyond the literary sphere. Hereby, this book establishes the relationship between literary and medical narratives as reciprocal, in effect eroding boundaries between the life sciences and literary studies. As an interdisciplinary endeavor, this study contributes to literary studies, specifically to the fields of life writing, speculative fiction, and young adult fiction, it offers insights for the study of transplantation in the popular realm and adds to the medical humanities.







CRISPR Genome Surgery in Stem Cells and Disease Tissues


Book Description

CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature. - Provides a thorough review of CRISPR-Cas9, from discovery to therapy - Covers the latest advances in gene editing and its translational applications to various diseases - Written by global leaders in the fields of gene editing and stem cell therapy







Engineering Mineralized and Load Bearing Tissues


Book Description

This book offers a comprehensive overview of current challenges and strategies to regenerate load-bearing and calcified human tissues, including bone, cartilage,tendon, ligaments and dental structures (dentin, enamel, cementum and periodontal ligament). Tissue engineering has long held great promises as an improved treatment option for conditions affecting mineralized and load-bearing structures in the body. Although significant progress has been achieved in recent years, a number of challenges still exist. Scaffold vascularization, new biofabrication methods (3D printing, lithography, microfabrication), peptide conjugation methods, interface engineering, scaffold mechanical properties, iPS cells, organs-on-a-chip, are some of the topics discussed in this book. More specially, in the first section readers will find an overview of emerging biofabrication methods. In section 2, applied strategies for regeneration of (2.1) bone, cartilage and ligament, as well as (2.2) dentin, cementum, enamel and periodontal ligament are discussed across 14 chapters. While other volumes have addressed the regeneration of individual tissues, or exclusively focused on different regenerative strategies, the focus of this work is to bring together researchers integrating backgrounds in materials sciences, engineering, biology, mechanics, fluidics, etc, to address specific challenges common to regeneration of several load-bearing and calcified tissues. Therefore, this book provides a unique platform to stimulate progress in the regeneration of functional tissue substitutes. We envision that this book will represent a valuable reference source for university and college faculties, post‐doctoral research fellows, senior graduate students, and researchers from R&D laboratories in their endeavors to fabricate biomimetic load bearing tissues.




SEC/CFTC Jurisdictional Issues and Oversight


Book Description




Contemporary Moral and Social Issues


Book Description

Contemporary Moral and Social Issues is a uniquely entertaining introduction that brings ethical thought to life. It makes innovative use of engaging, topically oriented original short fiction, together with classic and influential readings and editorial discussion as a means of helping students think philosophically about ethical theory and practical ethical problems. Introduces students to ethical theory and a range of practical moral issues through a combination of key primary texts, clear editorial commentary, and engaging, original fiction Includes discussion of topics such as world poverty, abortion, animals, the environment, and genetic engineering, containing “Facts and Factual Issues” for each topic to give students an up-to-date understanding of related factual issues. Uses immersive, original short works of fiction as a means to engage students to think philosophically about serious ethical issues Sample Course Framework available




Mechanical Properties of Aging Soft Tissues


Book Description

Exploring the structure and mechanics of aging soft tissues, this edited volume presents authoritative reviews from leading experts on a range of tissues including skin, tendons, vasculature and plantar soft tissues. It provides an overview of in vivo and in vitro measurement techniques including state-of-the-art methodologies, as well as focusing on the structural changes that occur within the main components of these tissues resulting in detrimental mechanical property changes. It also highlights the current challenges of this field, and offers an insight into future developments. Age-related changes in the mechanical properties of soft tissues have a profound effect on human morbidity and mortality, and with changing global demographics, there is growing interest in this area. There has been increasing interest in robustly characterizing these mechanical changes to develop structure-property relationships, and growing awareness of the need for enhanced predictive models for computational simulations. This book seeks to address the challenges involved in applying these engineering techniques to reliably characterize these tissues. Focusing on a wide range of tissues and presenting cutting-edge techniques, this book provides an invaluable reference to academics and researchers in a range of disciplines including biomechanics, materials science, tissue engineering, life sciences and biomedicine.




Police Services


Book Description

This volume provides fresh insights and management understanding of the changing role of policing against the backdrop of massive cuts in public expenditure experienced and the changing landscape of policing. The challenges of funding, training, online-crimes and cultural transformation are now felt globally. The need to learn and adapt from suitable models of police service delivery have never been greater. The book offers critical insights into the theory and practice of strategic and operational management of police services and the related professional and policy aspects. One of the highlight of this volume is to bring together scholarship using experts- academics, practitioners and professionals in the field, to each of the chosen topics. The chapters are based in the practical experiences of the authors and are written in a way that is accessible and suitable for a range of audiences. We are confident that this book will cater to a wider audience to inform policy and practice, both in the UK and internationally. Sir Peter Fahy QPM, Chief Constable, Greater Manchester Police Policing across the world is facing an increasing complexity of demand and public expectation creating new challenges for leadership and management. The contributors to this work are among the leading thinkers in policing and present important new insights into both the past and the way forward. It will be welcomed by all those convinced that radical new approaches are required across the public services. Bill Skelly, Deputy Chief Constable, Devon and Cornwall Police, UK At times it feels that the focus on leadership in the police service is all about what went wrong; the negative influences of a tightly-knit culture; and the almost inevitable rise of the technocrat. It is refreshing to read a book that seeks new insights into the positive influences of police leadership and offers the prospect of a more emotionally aware and spiritually rich approach as to how those insights may be practically employed for the benefit of all in the police family and the communities we serve.