Molecular Biology of the Cell
Author :
Publisher :
Page : 0 pages
File Size : 26,81 MB
Release : 2002
Category : Cells
ISBN : 9780815332183
Neuromorphic Olfaction
Author : Krishna C. Persaud
Publisher : CRC Press
Page : 237 pages
File Size : 49,22 MB
Release : 2016-04-19
Category : Medical
ISBN : 1439871728
Book Description
Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p
G Protein Pathways
Author : Ravi Iyengar
Publisher : Gulf Professional Publishing
Page : 724 pages
File Size : 42,20 MB
Release : 2002
Category : Cell receptors
ISBN : 9780121822446
Book Description
G Protein Pathways is the first of three volumes examining the nature of heterotrimeric G proteins. The text takes an integrated approach to studying common experimental questions at many different levels related to G proteins. Methods related to G proteins using molecular modeling, systems biology, protein engineering, protein biochemistry, cell biology, and physiology are all accessible in the same volume. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
Author : Denis J. Dupré
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 23,43 MB
Release : 2012-11-19
Category : Medical
ISBN : 9400747659
Book Description
Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.
G Protein-Coupled Receptor Signaling
Author : Mario Tiberi
Publisher : Humana Press
Page : 406 pages
File Size : 36,2 MB
Release : 2019-03-01
Category : Science
ISBN : 9781493991204
Book Description
This detailed volume assembles comprehensive protocols to assist with the study of structural, molecular, cell biological, and in vivo facets of GPCRs, and to enable the development of experimental tools for screening novel GPCR drugs. Sections explore the tweaking of ligands, bioluminescence and FRET approaches, specific GPCR signaling properties, as well as visualization of subcellular compartmentalization. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, G Protein-Coupled Receptor Signaling: Methods and Protocols serves as an ideal reference for life scientists working in a variety of research fields including molecular pharmacology, cell and developmental biology, brain behavior and physiology, drug development and screening. Chapter 4 is available open access under a CC BY 4.0 license via link.springer.com.
Principles of Endocrinology and Hormone Action
Author : Antonino Belfiore
Publisher : Springer
Page : 0 pages
File Size : 34,6 MB
Release : 2018-02-08
Category : Medical
ISBN : 9783319446745
Book Description
This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.
G-Protein-Coupled Receptor Dimers
Author : Katharine Herrick-Davis
Publisher : Humana Press
Page : 501 pages
File Size : 49,79 MB
Release : 2017-09-12
Category : Medical
ISBN : 9783319601724
Book Description
G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.
RGS Protein Physiology and Pathophysiology
Author :
Publisher : Academic Press
Page : 243 pages
File Size : 30,12 MB
Release : 2015-06-23
Category : Science
ISBN : 0128029544
Book Description
RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. - Brings together information on the current state of the RGS protein field - Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking - Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery
G Protein-Coupled Receptor Screening Assays
Author : Sofia Aires M. Martins
Publisher : Humana
Page : 327 pages
File Size : 10,83 MB
Release : 2022-06-19
Category : Science
ISBN : 9781071612231
Book Description
This fully updated edition targets not only those assays directly involved in the discovery of GPCR-active compounds but also those involved in cell-based experiments designed to study physiological responses. Whether coming from academia or industry, or being an experienced researcher or a newcomer to the field, the reader will find accessible methods and protocols that cover the latest developments on receptor purification, molecular biology, recombinant engineering, and analytical techniques that enable the real time monitoring of the complex GPCR signaling cascade and identification of potential drug targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, G Protein-Coupled Receptor Screening Assays: Methods and Protocols, Second Edition aims to provide the tools necessary to contribute to the advancement of GPCR research and discovery and ultimately lead to the availability of innovative and more efficient drugs.
Physics, Pharmacology and Physiology for Anaesthetists
Author : Matthew E. Cross
Publisher : Cambridge University Press
Page : 439 pages
File Size : 31,90 MB
Release : 2014-03-06
Category : Medical
ISBN : 1107615887
Book Description
A quick reference to basic science for anaesthetists, containing all the key information needed for FRCA exams.
