Molecular Biology of the Cell
Author :
Publisher :
Page : 0 pages
File Size : 22,46 MB
Release : 2002
Category : Cells
ISBN : 9780815332183
Gap Junctions in the Brain
Author : Ekrem Dere
Publisher : Academic Press
Page : 317 pages
File Size : 48,85 MB
Release : 2012-12-12
Category : Medical
ISBN : 0124159273
Book Description
Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants. - Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain - Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes - Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants
Gap Junction Structure and Chemical Regulation
Author : Camillo Peracchia
Publisher : Academic Press
Page : 230 pages
File Size : 13,63 MB
Release : 2019-02-16
Category : Science
ISBN : 0128163801
Book Description
Gap Junction Structure and Chemical Regulation: Direct Calmodulin Role in Cell-to-Cell Channel Gating describes and discusses the findings of major studies conducted during the past century on the structure and chemical regulation of direct cell-to-cell communication via gap junction channels. Chapters bring together important findings on direct cell communication, from its history, to its structure and regulation. These channels are essential for normal organ function, and mutations in their protein (connexin) cause various diseases. The book is useful for established investigators who need a review on the field and young investigators who need a thorough resource for study and comprehension. - Contains comprehensive, historical coverage on direct cell-to-cell communication - Provides detailed coverage of gap junction channel structure and regulation, with extensive coverage of the direct role of calmodulin in channel gating - Delivers a thorough description of models proposed for the chemical gating of gap junction channels
Gap Junctions in the Nervous System
Author : David C. Spray
Publisher : Springer Science & Business Media
Page : 321 pages
File Size : 45,6 MB
Release : 2013-06-29
Category : Medical
ISBN : 3662219352
Book Description
This book deals with the types of gap junction proteins (connexins) and their distribution within the nervous system, the physiological properties of channels formed of each connexin, and the role of gap junction channels in functions of normal and pathological brain and peripheral nerve. Although glial tissue is emphasized, additional groups of chapters deal with neurons in the central nervous system and with the retina.
Gap Junctions: Molecular Basis of Cell Communication in Health and Disease
Author : Dale J. Benos
Publisher : Gulf Professional Publishing
Page : 692 pages
File Size : 46,19 MB
Release : 1999-12-14
Category : Medical
ISBN : 9780125506458
Book Description
Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot-Marie-Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas disease.
Regenerative Pharmacology
Author : George J. Christ
Publisher : Cambridge University Press
Page : 361 pages
File Size : 24,92 MB
Release : 2013-04-15
Category : Medical
ISBN : 0521899494
Book Description
A state-of-the-art primer on the role of pharmacological sciences in regenerative medicine, for advanced students, postdoctoral fellows, and researchers.
Cells: Molecules and Mechanisms
Author : Eric Wong
Publisher : Axolotl Academic Publishing
Page : 283 pages
File Size : 38,84 MB
Release : 2009
Category : Biology
ISBN : 0985226110
Book Description
"Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.
Tight Junctions in Cancer Metastasis
Author : Tracey A. Martin
Publisher : Springer Science & Business Media
Page : 315 pages
File Size : 27,18 MB
Release : 2013-02-26
Category : Medical
ISBN : 9400760280
Book Description
There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.
Intercellular Communication through Gap Junctions
Author : Y. Kanno
Publisher : Newnes
Page : 474 pages
File Size : 31,25 MB
Release : 1995-02-09
Category : Science
ISBN : 0444599525
Book Description
Research on intercellular communication through gap junctions has continued to expand, and the meeting on which this book is based brought together many scientists from many different countries and disciplines. In line with the objective of the meeting, this volume focuses on the biological meaning of intercellular communication through gap junctions in various organs. The most recent up-to-date findings have been included in this extensive volume, valuable to all those interested in this rapidly expanding field.
Cardiac Gap Junctions
Author : Stefan Dhein
Publisher : Karger Medical and Scientific Publishers
Page : 155 pages
File Size : 30,45 MB
Release : 1998-01-01
Category : Science
ISBN : 3805565674
Book Description
Provides an overview of what is currently known about cardiac gap junctions. An introduction into the various aspects of activation propogation and coupling in the heart is followed by a detailed description of the structure and diversity of gap junctions.
